Polymorphism of the Androgen Receptor Gene is Associated with Male Pattern Baldness

The common heritable loss of scalp hair known as male pattern baldness or androgenetic alopecia affects up to 80% of males by age 80. A balding scalp is characterized by high levels of the potent androgen dihydrotestosterone and increased expression of the androgen receptor gene. To determine if the...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Journal of investigative dermatology Jg. 116; H. 3; S. 452 - 455
Hauptverfasser: Ellis, Justine A., Stebbing, Margaret, Harrap, Stephen B.
Format: Journal Article
Sprache:Englisch
Veröffentlicht: Danvers, MA Elsevier Inc 01.03.2001
Nature Publishing
Elsevier Limited
Schlagworte:
Adult
alopecia
Alopecia - classification
Alopecia - epidemiology
Alopecia - genetics
androgens
Australia
Biological and medical sciences
Dermatology
Exons
genetics
Hair and nails disorders
hair loss
Humans
Incidence
Male
Medical sciences
Middle Aged
Phenotype
Polymorphism, Genetic
Polymorphism, Restriction Fragment Length
Receptors, Androgen - genetics
Reference Values
testosterone
Trinucleotide Repeats
Australia
hair loss
genetics
alopecia
androgens
testosterone
Hair (head)
Human
Skin disease
Androgen
Gene
Genetics
Sex steroid hormone
Androgenetic alopecia
Polymorphism
Hormonal receptor
ISSN:0022-202X, 1523-1747
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:The common heritable loss of scalp hair known as male pattern baldness or androgenetic alopecia affects up to 80% of males by age 80. A balding scalp is characterized by high levels of the potent androgen dihydrotestosterone and increased expression of the androgen receptor gene. To determine if the androgen receptor gene is associated with male pattern baldness, we compared allele frequencies of the androgen receptor gene polymorphisms (StuI restriction fragment length polymorphism and two triplet repeat polymorphisms) in cases with cosmetically significant baldness (54 young and 392 older men) and controls (107 older men) with no indication of baldness. The androgen receptor gene StuI restriction site was found in all but one (98.1%) of the 54 young bald men (p =0.0005) and in 92.3% of older balding men (p =0.000004) but in only 76.6% of nonbald men. The combination of shorter CAG and GGC triplet repeat lengths was also more prevalent in bald men (p =0.03). The ubiquity of the androgen receptor gene StuI restriction site, and higher incidence of shorter triplet repeat haplotypes in bald men suggests that these markers are very close to a functional variant that is a necessary component of the polygenic determination of male pattern baldness. Functional mutation in or near the androgen receptor gene may explain the reported high levels of expression of this gene in the balding scalp.
Bibliographie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
content type line 23
ISSN:0022-202X
1523-1747
DOI:10.1046/j.1523-1747.2001.01261.x