CK1δ/ε protein kinase primes the PER2 circadian phosphoswitch

Multisite phosphorylation of the PERIOD 2 (PER2) protein is the key step that determines the period of the mammalian circadian clock. Previous studies concluded that an unidentified kinase is required to prime PER2 for subsequent phosphorylation by casein kinase 1 (CK1), an essential clock component...

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Vydané v:	Proceedings of the National Academy of Sciences - PNAS Ročník 115; číslo 23; s. 5986
Hlavní autori:	Narasimamurthy, Rajesh, Hunt, Sabrina R, Lu, Yining, Fustin, Jean-Michel, Okamura, Hitoshi, Partch, Carrie L, Forger, Daniel B, Kim, Jae Kyoung, Virshup, David M
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States 05.06.2018
Predmet:	Animals Casein Kinase Idelta - metabolism Casein Kinase Iepsilon - metabolism Circadian Rhythm - physiology HEK293 Cells Humans Mice Period Circadian Proteins - genetics Period Circadian Proteins - metabolism Phosphorylation cell regulation circadian rhythms protein kinase
ISSN:	1091-6490, 1091-6490
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