CK1δ/ε protein kinase primes the PER2 circadian phosphoswitch

Multisite phosphorylation of the PERIOD 2 (PER2) protein is the key step that determines the period of the mammalian circadian clock. Previous studies concluded that an unidentified kinase is required to prime PER2 for subsequent phosphorylation by casein kinase 1 (CK1), an essential clock component...

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Bibliographic Details

Published in:	Proceedings of the National Academy of Sciences - PNAS Vol. 115; no. 23; p. 5986
Main Authors:	Narasimamurthy, Rajesh, Hunt, Sabrina R, Lu, Yining, Fustin, Jean-Michel, Okamura, Hitoshi, Partch, Carrie L, Forger, Daniel B, Kim, Jae Kyoung, Virshup, David M
Format:	Journal Article
Language:	English
Published:	United States 05.06.2018
Subjects:	Animals Casein Kinase Idelta - metabolism Casein Kinase Iepsilon - metabolism Circadian Rhythm - physiology HEK293 Cells Humans Mice Period Circadian Proteins - genetics Period Circadian Proteins - metabolism Phosphorylation cell regulation circadian rhythms protein kinase
ISSN:	1091-6490, 1091-6490
Online Access:	Get more information
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