Yeast as a model system to study RecQ helicase function

Mutations in the highly conserved RecQ helicase, BLM, cause the rare cancer predisposition disorder, Bloom's syndrome. The orthologues of BLM in Saccharomyces cerevisiae and Schizosaccharomyces pombe are SGS1 and rqh1+, respectively. Studies in these yeast species have revealed a plethora of ro...

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Vydané v:	DNA repair Ročník 9; číslo 3; s. 303 - 314
Hlavní autori:	Ashton, Thomas M., Hickson, Ian D.
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	Netherlands Elsevier B.V 02.03.2010
Predmet:	Animals Bloom's syndrome DNA Breaks, Double-Stranded DNA Helicases - metabolism DNA Repair DNA, Fungal - metabolism Homologous recombination Humans RecQ Helicases - metabolism Rqh1 Saccharomyces cerevisiae Saccharomyces cerevisiae - cytology Saccharomyces cerevisiae - enzymology Saccharomyces cerevisiae Proteins - metabolism Schizosaccharomyces - cytology Schizosaccharomyces - enzymology Schizosaccharomyces pombe Schizosaccharomyces pombe Proteins - metabolism Sgs1 Bloom's syndrome Sgs1 Homologous recombination Rqh1
ISSN:	1568-7864, 1568-7856, 1568-7856
On-line prístup:	Získať plný text
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