Association of Adiponectin Gene Variations with Risk of Incident Myocardial Infarction and Ischemic Stroke: A Nested Case-Control Study

Background: Adiponectin (ADIPOQ) gene variations are associated with risk of cardiovascular disease in patients with diabetes. No prospective data are available, however, on the risk of atherothrombotic disorders in persons with ADIPOQ variations who do not have diabetes. Methods: From a group of DN...

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Veröffentlicht in:Clinical chemistry (Baltimore, Md.) Jg. 52; H. 11; S. 2021 - 2027
Hauptverfasser: Hegener, Hillary H, Lee, I-Min, Cook, Nancy R, Ridker, Paul M, Zee, Robert Y.L
Format: Journal Article
Sprache:Englisch
Veröffentlicht: Washington, DC Am Assoc Clin Chem 01.11.2006
American Association for Clinical Chemistry
Oxford University Press
Schlagworte:
Adiponectin - genetics
Analytical, structural and metabolic biochemistry
Biological and medical sciences
Biological variation
Cardiovascular disease
Cardiovascular diseases
Case studies
Case-Control Studies
Comorbidity
European Continental Ancestry Group - genetics
Follow-Up Studies
Fundamental and applied biological sciences. Psychology
Genes
Genetic variance
Genetic Variation
Health risks
Humans
Incidence
Investigative techniques, diagnostic techniques (general aspects)
Ischemia - diagnosis
Ischemia - epidemiology
Ischemia - genetics
Male
Medical sciences
Middle Aged
Myocardial infarction
Myocardial Infarction - diagnosis
Myocardial Infarction - epidemiology
Myocardial Infarction - genetics
Prospective Studies
Reference Values
Regression analysis
Risk Factors
Stroke
Stroke - diagnosis
Stroke - epidemiology
Stroke - genetics
United States - epidemiology
Vascular diseases
United States
Myocardial infarction
Cerebral infarction
Nervous system diseases
Stroke
Cardiovascular disease
Biochemistry
Case control study
Myocardial disease
Epidemiology
Cerebral disorder
Adiponectin
Vascular disease
Association
Gene
Heart disease
Central nervous system disease
Clinical biology
Risk factor
Genetics
Molecular biology
Cerebrovascular disease
ISSN:0009-9147, 1530-8561
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Zusammenfassung:Background: Adiponectin (ADIPOQ) gene variations are associated with risk of cardiovascular disease in patients with diabetes. No prospective data are available, however, on the risk of atherothrombotic disorders in persons with ADIPOQ variations who do not have diabetes. Methods: From a group of DNA samples collected at baseline in a prospective cohort of 14 916 initially healthy American men, we assessed the presence of 5 ADIPOQ genetic variants (rs266729, rs182052, rs822396, rs2241766, and rs1501299) in samples from 600 Caucasian men who subsequently suffered an atherothrombotic event (incident myocardial infarction or ischemic stroke) and from 600 age- and smoking-matched Caucasian men who remained free of reported vascular disease during follow-up (controls). Results: Genotype distributions for the variations tested were in Hardy-Weinberg equilibrium. Marker-by-marker conditional logistic regression analysis, adjusted for potential risk factors, showed an association of rs266729 [recessive: odds ratio (OR), 0.26; 95% confidence interval (CI), 0.10–0.64; P = 0.004] and rs182052 (recessive: OR, 0.40; 95% CI, 0.21–0.76; P = 0.006) with decreased risk of ischemic stroke. These findings remained significant after Bonferroni correction. Haplotype-based (constituted by rs266729, rs182052, and rs822396) conditional logistic regression analysis, adjusted for the same potential risk factors, showed an association of haplotype G-A-G (OR, 0.28; 95% CI, 0.09–0.87; P = 0.03) with decreased risk of ischemic stroke. Prespecified analysis limited to participants without baseline diabetes showed similar significant findings. Conclusions: The present prospective investigation provides further evidence for a protective role of adiponectin gene variation in the risk of ischemic stroke that was independent of the presence of diabetes.
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ISSN:0009-9147
1530-8561
DOI:10.1373/clinchem.2006.074476