The role of anti-vascular endothelial growth factor (anti-VEGF) in the management of proliferative diabetic retinopathy

Diabetes is a major cause of visual impairment among working-age adults in the United States. The proliferative form of diabetic retinopathy is associated with severe vision loss (acuity <5/200). The standard treatment in proliferative diabetic retinopathy (PDR) is panretinal photocoagulation (PR...

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Veröffentlicht in:Drugs in Context Jg. 7; S. 212532 - 10
Hauptverfasser: Zhao, Yue, Singh, Rishi P
Format: Journal Article
Sprache:Englisch
Veröffentlicht: England BioExcel Publishing Ltd 13.08.2018
Schlagworte:
aflibercept
angiogenesis inhibitors
antibodies
bevacizumab
diabetic retinopathy
humanized antibodies
intravitreal injection
monoclonal
ranibizumab
Review
vascular endothelial growth factor A
aflibercept
bevacizumab
antibodies
monoclonal
intravitreal injection
angiogenesis inhibitors
diabetic retinopathy
vascular endothelial growth factor A
humanized antibodies
ranibizumab
ISSN:1745-1981, 1740-4398, 1740-4398
Online-Zugang:Volltext
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Zusammenfassung:Diabetes is a major cause of visual impairment among working-age adults in the United States. The proliferative form of diabetic retinopathy is associated with severe vision loss (acuity <5/200). The standard treatment in proliferative diabetic retinopathy (PDR) is panretinal photocoagulation (PRP), which is effective but has established side effects such as peripheral visual-field constraints. Vascular endothelial growth factor (VEGF) is thought to drive the process of vascular proliferation. Drugs targeting VEGF (anti-VEGF) have been studied extensively in diabetic macular edema (DME), and results have shown that diabetic retinopathy regresses with anti-VEGF treatment. Recent studies show that anti-VEGF is not inferior to PRP for PDR while treatment is maintained, though recurrence rate when anti-VEGF treatment is stopped is unclear. In vitreous hemorrhage where PRP cannot be performed, use of anti-VEGF medications can treat underlying PDR and delay or reduce need for vitrectomy. Limitations of anti-VEGF treatment, however, require careful patient selection and monitoring. This review discusses recent clinical trials and guidelines for anti-VEGF use in PDR.
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ISSN:1745-1981
1740-4398
1740-4398
DOI:10.7573/dic.212532