Intravital imaging technology guides FAK-mediated priming in pancreatic cancer precision medicine according to Merlin status

Intravital imaging guides a personalized medicine approach to target mechanoreciprocity in pancreatic cancer. Pancreatic ductal adenocarcinoma (PDAC) is a highly metastatic, chemoresistant malignancy and is characterized by a dense, desmoplastic stroma that modulates PDAC progression. Here, we visua...

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Veröffentlicht in:	Science advances Jg. 7; H. 40; S. eabh0363
Hauptverfasser:	Murphy, Kendelle J., Reed, Daniel A., Vennin, Claire, Conway, James R. W., Nobis, Max, Yin, Julia X., Chambers, Cecilia R., Pereira, Brooke A., Lee, Victoria, Filipe, Elysse C., Trpceski, Michael, Ritchie, Shona, Lucas, Morghan C., Warren, Sean C., Skhinas, Joanna N., Magenau, Astrid, Metcalf, Xanthe L., Stoehr, Janett, Major, Gretel, Parkin, Ashleigh, Bidanel, Romain, Lyons, Ruth J., Zaratzian, Anaiis, Tayao, Michael, Da Silva, Andrew, Abdulkhalek, Lea, Gill, Anthony J., Johns, Amber L., Biankin, Andrew V., Samra, Jaswinder, Grimmond, Sean M., Chou, Angela, Goetz, Jacky G., Samuel, Michael S., Lyons, J. Guy, Burgess, Andrew, Caldon, C. Elizabeth, Horvath, Lisa G., Daly, Roger J., Gadegaard, Nikolaj, Wang, Yingxiao, Sansom, Owen J., Morton, Jennifer P., Cox, Thomas R., Pajic, Marina, Herrmann, David, Timpson, Paul
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States American Association for the Advancement of Science (AAAS) 01.10.2021 American Association for the Advancement of Science
Schlagworte:	Biomedicine and Life Sciences Cancer Cell Biology Computer Science Medical Imaging SciAdv r-articles
ISSN:	2375-2548, 2375-2548
Online-Zugang:	Volltext
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