Accuracy of central neuro-imaging review of DIPG compared with histopathology in the International DIPG Registry

Diffuse intrinsic pontine glioma (DIPG) remains a clinico-radiologic diagnosis without routine tissue acquisition. Reliable imaging distinction between DIPG and other pontine tumors with potentially more favorable prognoses and treatment considerations is essential. Cases submitted to the Internatio...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Neuro-oncology (Charlottesville, Va.) Jg. 24; H. 5; S. 821
Hauptverfasser: Lazow, Margot A, Fuller, Christine, DeWire, Mariko, Lane, Adam, Bandopadhayay, Pratiti, Bartels, Ute, Bouffet, Eric, Cheng, Sylvia, Cohen, Kenneth J, Cooney, Tabitha M, Coven, Scott L, Dholaria, Hetal, Diez, Blanca, Dorris, Kathleen, El-Ayadi, Moatasem, El-Sheikh, Ayman, Fisher, Paul G, Fonseca, Adriana, Garcia Lombardi, Mercedes, Greiner, Robert J, Goldman, Stewart, Gottardo, Nicholas, Gururangan, Sridharan, Hansford, Jordan R, Hassall, Tim, Hawkins, Cynthia, Kilburn, Lindsay, Koschmann, Carl, Leary, Sarah E, Ma, Jie, Minturn, Jane E, Monje-Deisseroth, Michelle, Packer, Roger, Samson, Yvan, Sandler, Eric S, Sevlever, Gustavo, Tinkle, Christopher L, Tsui, Karen, Wagner, Lars M, Zaghloul, Mohamed, Ziegler, David S, Chaney, Brooklyn, Black, Katie, Asher, Anthony, Drissi, Rachid, Fouladi, Maryam, Jones, Blaise V, Leach, James L
Format: Journal Article
Sprache:Englisch
Veröffentlicht: England 04.05.2022
Schlagworte:
Astrocytoma
Brain Stem Neoplasms - pathology
Glioma - diagnostic imaging
Glioma - pathology
Humans
Registries
histopathology
non-DIPG
pontine tumor
DIPG
central imaging review
ISSN:1523-5866, 1523-5866
Online-Zugang:Weitere Angaben
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Diffuse intrinsic pontine glioma (DIPG) remains a clinico-radiologic diagnosis without routine tissue acquisition. Reliable imaging distinction between DIPG and other pontine tumors with potentially more favorable prognoses and treatment considerations is essential. Cases submitted to the International DIPG registry (IDIPGR) with histopathologic and/or radiologic data were analyzed. Central imaging review was performed on diagnostic brain MRIs (if available) by two neuro-radiologists. Imaging features suggestive of alternative diagnoses included nonpontine origin, <50% pontine involvement, focally exophytic morphology, sharply defined margins, and/or marked diffusion restriction throughout. Among 286 patients with pathology from biopsy and/or autopsy, 23 (8%) had histologic diagnoses inconsistent with DIPG, most commonly nondiffuse low-grade gliomas and embryonal tumors. Among 569 patients with centrally-reviewed diagnostic MRIs, 40 (7%) were classified as non-DIPG, alternative diagnosis suspected. The combined analysis included 151 patients with both histopathology and centrally-reviewed MRI. Of 77 patients with imaging classified as characteristic of DIPG, 76 (99%) had histopathologic diagnoses consistent with DIPG (infiltrating grade II-IV gliomas). Of 57 patients classified as likely DIPG with some unusual imaging features, 55 (96%) had histopathologic diagnoses consistent with DIPG. Of 17 patients with imaging features suggestive of an alternative diagnosis, eight (47%) had histopathologic diagnoses inconsistent with DIPG (remaining patients were excluded due to nonpontine tumor origin). Association between central neuro-imaging review impression and histopathology was significant (p < 0.001), and central neuro-imaging impression was prognostic of overall survival. The accuracy and important role of central neuro-imaging review in confirming the diagnosis of DIPG is demonstrated.
Bibliographie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1523-5866
1523-5866
DOI:10.1093/neuonc/noab245