Okadaic acid (OA): Toxicity, detection and detoxification
Okadaic acid (OA), a potent polyether marine toxin, accumulates in the digestive glands of marine mollusks and therefore can severely threaten the health of humans after ingestion of contaminated shellfish. In vivo and in vitro studies have revealed that exposure of various cells, including human em...
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| Published in: | Toxicon (Oxford) Vol. 160; pp. 1 - 7 |
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| Main Authors: | , , , |
| Format: | Journal Article |
| Language: | English |
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England
Elsevier Ltd
15.03.2019
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| ISSN: | 0041-0101, 1879-3150, 1879-3150 |
| Online Access: | Get full text |
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| Abstract | Okadaic acid (OA), a potent polyether marine toxin, accumulates in the digestive glands of marine mollusks and therefore can severely threaten the health of humans after ingestion of contaminated shellfish. In vivo and in vitro studies have revealed that exposure of various cells, including human embryonic amniotic cells, hepatocytes, neuroblastoma cells, to OA induces morphological and functional modifications as well as the death of cells. As the number of reports on OA poisoning has increased, this toxin has gradually attracted the public's attention, and researchers are trying to study it. This review summarizes the current literature on the toxicity effects of OA, in addition to its detection and detoxification. |
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| AbstractList | Okadaic acid (OA), a potent polyether marine toxin, accumulates in the digestive glands of marine mollusks and therefore can severely threaten the health of humans after ingestion of contaminated shellfish. In vivo and in vitro studies have revealed that exposure of various cells, including human embryonic amniotic cells, hepatocytes, neuroblastoma cells, to OA induces morphological and functional modifications as well as the death of cells. As the number of reports on OA poisoning has increased, this toxin has gradually attracted the public's attention, and researchers are trying to study it. This review summarizes the current literature on the toxicity effects of OA, in addition to its detection and detoxification. Okadaic acid (OA), a potent polyether marine toxin, accumulates in the digestive glands of marine mollusks and therefore can severely threaten the health of humans after ingestion of contaminated shellfish. In vivo and in vitro studies have revealed that exposure of various cells, including human embryonic amniotic cells, hepatocytes, neuroblastoma cells, to OA induces morphological and functional modifications as well as the death of cells. As the number of reports on OA poisoning has increased, this toxin has gradually attracted the public's attention, and researchers are trying to study it. This review summarizes the current literature on the toxicity effects of OA, in addition to its detection and detoxification.Okadaic acid (OA), a potent polyether marine toxin, accumulates in the digestive glands of marine mollusks and therefore can severely threaten the health of humans after ingestion of contaminated shellfish. In vivo and in vitro studies have revealed that exposure of various cells, including human embryonic amniotic cells, hepatocytes, neuroblastoma cells, to OA induces morphological and functional modifications as well as the death of cells. As the number of reports on OA poisoning has increased, this toxin has gradually attracted the public's attention, and researchers are trying to study it. This review summarizes the current literature on the toxicity effects of OA, in addition to its detection and detoxification. |
| Author | Fu, Ling-ling Xu, Jin Ji, Lin-dan Zhao, Xiao-yu |
| Author_xml | – sequence: 1 givenname: Ling-ling surname: Fu fullname: Fu, Ling-ling organization: Department of Preventive Medicine, School of Medicine, Ningbo University, Ningbo, Zhejiang Province, China – sequence: 2 givenname: Xiao-yu surname: Zhao fullname: Zhao, Xiao-yu organization: Department of Preventive Medicine, School of Medicine, Ningbo University, Ningbo, Zhejiang Province, China – sequence: 3 givenname: Lin-dan surname: Ji fullname: Ji, Lin-dan organization: Department of Biochemistry, School of Medicine, Ningbo University, Ningbo, Zhejiang Province, China – sequence: 4 givenname: Jin surname: Xu fullname: Xu, Jin email: xujin1@nbu.edu.cn organization: Department of Preventive Medicine, School of Medicine, Ningbo University, Ningbo, Zhejiang Province, China |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/30639658$$D View this record in MEDLINE/PubMed |
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| Keywords | Okadaic acid Protein phosphatase Diarrhetic shellfish poisoning Detection Detoxification |
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