Okadaic acid (OA): Toxicity, detection and detoxification

Okadaic acid (OA), a potent polyether marine toxin, accumulates in the digestive glands of marine mollusks and therefore can severely threaten the health of humans after ingestion of contaminated shellfish. In vivo and in vitro studies have revealed that exposure of various cells, including human em...

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Bibliographic Details
Published in:Toxicon (Oxford) Vol. 160; pp. 1 - 7
Main Authors: Fu, Ling-ling, Zhao, Xiao-yu, Ji, Lin-dan, Xu, Jin
Format: Journal Article
Language:English
Published: England Elsevier Ltd 15.03.2019
Subjects:
death
Detection
Detoxification
Diarrhetic shellfish poisoning
hepatocytes
human health
humans
in vitro studies
ingestion
molluscs
Okadaic acid
poisoning
Protein phosphatase
researchers
shellfish
toxicity
Okadaic acid
Protein phosphatase
Diarrhetic shellfish poisoning
Detection
Detoxification
ISSN:0041-0101, 1879-3150, 1879-3150
Online Access:Get full text
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Summary:Okadaic acid (OA), a potent polyether marine toxin, accumulates in the digestive glands of marine mollusks and therefore can severely threaten the health of humans after ingestion of contaminated shellfish. In vivo and in vitro studies have revealed that exposure of various cells, including human embryonic amniotic cells, hepatocytes, neuroblastoma cells, to OA induces morphological and functional modifications as well as the death of cells. As the number of reports on OA poisoning has increased, this toxin has gradually attracted the public's attention, and researchers are trying to study it. This review summarizes the current literature on the toxicity effects of OA, in addition to its detection and detoxification.
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ISSN:0041-0101
1879-3150
1879-3150
DOI:10.1016/j.toxicon.2018.12.007