Okadaic acid (OA): Toxicity, detection and detoxification
Okadaic acid (OA), a potent polyether marine toxin, accumulates in the digestive glands of marine mollusks and therefore can severely threaten the health of humans after ingestion of contaminated shellfish. In vivo and in vitro studies have revealed that exposure of various cells, including human em...
Uloženo v:
| Vydáno v: | Toxicon (Oxford) Ročník 160; s. 1 - 7 |
|---|---|
| Hlavní autoři: | , , , |
| Médium: | Journal Article |
| Jazyk: | angličtina |
| Vydáno: |
England
Elsevier Ltd
15.03.2019
|
| Témata: | |
| ISSN: | 0041-0101, 1879-3150, 1879-3150 |
| On-line přístup: | Získat plný text |
| Tagy: |
Přidat tag
Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!
|
| Abstract | Okadaic acid (OA), a potent polyether marine toxin, accumulates in the digestive glands of marine mollusks and therefore can severely threaten the health of humans after ingestion of contaminated shellfish. In vivo and in vitro studies have revealed that exposure of various cells, including human embryonic amniotic cells, hepatocytes, neuroblastoma cells, to OA induces morphological and functional modifications as well as the death of cells. As the number of reports on OA poisoning has increased, this toxin has gradually attracted the public's attention, and researchers are trying to study it. This review summarizes the current literature on the toxicity effects of OA, in addition to its detection and detoxification. |
|---|---|
| AbstractList | Okadaic acid (OA), a potent polyether marine toxin, accumulates in the digestive glands of marine mollusks and therefore can severely threaten the health of humans after ingestion of contaminated shellfish. In vivo and in vitro studies have revealed that exposure of various cells, including human embryonic amniotic cells, hepatocytes, neuroblastoma cells, to OA induces morphological and functional modifications as well as the death of cells. As the number of reports on OA poisoning has increased, this toxin has gradually attracted the public's attention, and researchers are trying to study it. This review summarizes the current literature on the toxicity effects of OA, in addition to its detection and detoxification. Okadaic acid (OA), a potent polyether marine toxin, accumulates in the digestive glands of marine mollusks and therefore can severely threaten the health of humans after ingestion of contaminated shellfish. In vivo and in vitro studies have revealed that exposure of various cells, including human embryonic amniotic cells, hepatocytes, neuroblastoma cells, to OA induces morphological and functional modifications as well as the death of cells. As the number of reports on OA poisoning has increased, this toxin has gradually attracted the public's attention, and researchers are trying to study it. This review summarizes the current literature on the toxicity effects of OA, in addition to its detection and detoxification.Okadaic acid (OA), a potent polyether marine toxin, accumulates in the digestive glands of marine mollusks and therefore can severely threaten the health of humans after ingestion of contaminated shellfish. In vivo and in vitro studies have revealed that exposure of various cells, including human embryonic amniotic cells, hepatocytes, neuroblastoma cells, to OA induces morphological and functional modifications as well as the death of cells. As the number of reports on OA poisoning has increased, this toxin has gradually attracted the public's attention, and researchers are trying to study it. This review summarizes the current literature on the toxicity effects of OA, in addition to its detection and detoxification. |
| Author | Fu, Ling-ling Xu, Jin Ji, Lin-dan Zhao, Xiao-yu |
| Author_xml | – sequence: 1 givenname: Ling-ling surname: Fu fullname: Fu, Ling-ling organization: Department of Preventive Medicine, School of Medicine, Ningbo University, Ningbo, Zhejiang Province, China – sequence: 2 givenname: Xiao-yu surname: Zhao fullname: Zhao, Xiao-yu organization: Department of Preventive Medicine, School of Medicine, Ningbo University, Ningbo, Zhejiang Province, China – sequence: 3 givenname: Lin-dan surname: Ji fullname: Ji, Lin-dan organization: Department of Biochemistry, School of Medicine, Ningbo University, Ningbo, Zhejiang Province, China – sequence: 4 givenname: Jin surname: Xu fullname: Xu, Jin email: xujin1@nbu.edu.cn organization: Department of Preventive Medicine, School of Medicine, Ningbo University, Ningbo, Zhejiang Province, China |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/30639658$$D View this record in MEDLINE/PubMed |
| BookMark | eNqFkUtLAzEUhYMotj5-gjJLBWe8eXSS6EJEfIHQTV2HNLkDqe1MnUxF_70Z227cdBWS-51zyTlHZL9uaiTkjEJBgZbXs6JrvoNr6oIBVQVlBYDcI0OqpM45HcE-GQIImkPCB-QoxhkAcKXLQzLgUHJdjtSQ6PGH9Ta4zLrgs4vx_eVNNumNQ_dzlXns0HWhqTNb-_6WJlVwtn86IQeVnUc83ZzH5P3pcfLwkr-Nn18f7t9yJ5jocuenQvuKU-E8syX3ljMnnUSpBHiwbsoUoqNIpaxkKdSoUlaWWqcRx5LyY3Kx9l22zecKY2cWITqcz22NzSoaxhgoIRhTu1EqNeeaM0jo-QZdTRfozbINC9v-mG0yCbhdA65tYmyxMimSv493rQ1zQ8H0PZiZ2fRg-h4MZSb1kNSjf-rtgl26u7UOU6JfAVsTXcDaoQ9tasL4Juxw-AWnxKNo |
| CitedBy_id | crossref_primary_10_1007_s13206_021_00013_4 crossref_primary_10_1016_j_ecoenv_2019_05_015 crossref_primary_10_1016_j_ecoenv_2025_118576 crossref_primary_10_1016_j_ijbiomac_2023_123170 crossref_primary_10_1016_j_foodchem_2023_136243 crossref_primary_10_1016_j_marenvres_2025_107412 crossref_primary_10_1007_s11694_024_02757_7 crossref_primary_10_1016_j_toxicon_2021_10_004 crossref_primary_10_1007_s00216_022_04298_8 crossref_primary_10_1016_j_heliyon_2024_e25564 crossref_primary_10_3390_jmse10091312 crossref_primary_10_1007_s11356_023_26471_x crossref_primary_10_1016_j_heliyon_2024_e27146 crossref_primary_10_3390_biom12111587 crossref_primary_10_1080_21655979_2022_2036918 crossref_primary_10_3390_biom12111668 crossref_primary_10_1007_s12601_025_00210_4 crossref_primary_10_3389_fmars_2022_961751 crossref_primary_10_3390_mi13091506 crossref_primary_10_1016_j_ecoenv_2024_116990 crossref_primary_10_3390_foods11030382 crossref_primary_10_1002_adfm_202415174 crossref_primary_10_1080_15287394_2020_1793046 crossref_primary_10_3390_foods11121691 crossref_primary_10_1016_j_foodcont_2023_109635 crossref_primary_10_1016_j_foodchem_2023_136374 crossref_primary_10_1016_j_snb_2020_128872 crossref_primary_10_1007_s10517_022_05386_6 crossref_primary_10_1007_s41664_022_00245_9 crossref_primary_10_1016_j_tox_2022_153209 crossref_primary_10_1016_j_hal_2022_102373 crossref_primary_10_1007_s13206_022_00056_1 crossref_primary_10_1016_j_envpol_2021_116942 crossref_primary_10_3390_ph17060734 crossref_primary_10_1016_j_fitote_2024_106193 crossref_primary_10_1016_j_microc_2020_105644 crossref_primary_10_3390_toxins15100587 crossref_primary_10_1016_j_bios_2022_114562 crossref_primary_10_1134_S1062359022140060 crossref_primary_10_4315_JFP_20_212 crossref_primary_10_1016_j_scitotenv_2021_145772 crossref_primary_10_1016_j_fsi_2024_109529 crossref_primary_10_3390_ijms25179194 crossref_primary_10_3390_molecules29204891 crossref_primary_10_3389_fmars_2021_638739 crossref_primary_10_1016_j_foodcont_2021_108428 crossref_primary_10_3390_md20030198 crossref_primary_10_3389_fmars_2023_1119370 crossref_primary_10_1016_j_chemosphere_2024_143419 crossref_primary_10_1016_j_foodchem_2024_141776 crossref_primary_10_1016_j_jhazmat_2023_132624 crossref_primary_10_1016_j_ecoenv_2025_119042 crossref_primary_10_1039_C9RA10600F crossref_primary_10_3390_molecules27227898 crossref_primary_10_3390_md20090556 crossref_primary_10_1007_s00204_024_03694_6 crossref_primary_10_3390_md19010023 crossref_primary_10_1016_j_aca_2024_343004 crossref_primary_10_3390_md19060322 crossref_primary_10_3390_toxins14120829 crossref_primary_10_3390_ph13080194 crossref_primary_10_26508_lsa_202201536 crossref_primary_10_3390_bios12121137 crossref_primary_10_3390_ijerph17134782 crossref_primary_10_1016_j_aca_2021_338887 crossref_primary_10_1016_j_aquatox_2023_106576 crossref_primary_10_1016_j_foodchem_2021_130856 crossref_primary_10_3389_fmars_2021_792050 crossref_primary_10_1016_j_heliyon_2022_e10444 |
| Cites_doi | 10.1016/j.toxicon.2015.06.030 10.1007/s00216-007-1778-x 10.1002/tox.20702 10.1186/s40478-016-0300-0 10.1039/c0em00771d 10.1016/j.toxicon.2015.10.002 10.1016/S0041-0101(96)00069-4 10.1080/15287394.2011.582026 10.1016/S0041-0101(98)00222-0 10.1016/S0041-0101(02)00111-3 10.3390/ijms19030645 10.1007/s11356-017-0472-6 10.1007/BF01816483 10.3390/toxins8060159 10.1016/j.aca.2012.02.035 10.1007/s00204-003-0505-4 10.1080/02772248.2012.730199 10.1016/j.toxicon.2005.07.007 10.1046/j.1471-4159.2001.00090.x 10.1016/j.fsi.2017.03.031 10.1016/S0021-9673(97)01164-3 10.1007/s002040050296 10.1042/bj2560283 10.3390/md11082829 10.1046/j.1471-4159.1998.70031124.x 10.1016/j.tiv.2014.09.002 10.1016/j.tox.2008.11.013 10.1002/tox.10140 10.1016/j.hal.2016.02.008 10.5740/jaoacint.10-412 10.1016/j.aquatox.2017.07.012 10.1113/jphysiol.1986.sp016224 10.1016/j.toxicon.2018.02.001 10.1016/j.fct.2017.01.008 10.1016/j.toxicon.2015.05.010 10.1016/j.toxicon.2005.10.012 10.1016/j.toxicon.2009.10.026 10.1016/j.toxicon.2016.12.005 10.3390/md11061763 10.1002/tox.20446 10.1080/15287394.2015.1051173 10.1021/ac902084a 10.1016/j.scitotenv.2005.03.002 10.1021/tx00028a003 10.1007/s00216-014-8378-3 10.1042/EBC20150006 10.1021/ja00399a081 10.1080/19440049.2016.1239032 10.1016/j.talanta.2013.05.057 10.1016/S0014-5793(01)02944-1 10.1042/bj2840539 10.1080/009841096161357 10.1111/bph.13759 10.1177/1535370216650759 10.1016/j.fct.2015.06.006 10.3390/md11114328 10.1016/j.jhazmat.2017.06.030 10.1002/1522-7189(199911/12)7:6<387::AID-NT87>3.0.CO;2-N 10.2116/analsci.27.571 10.2331/suisan.44.1249 10.1016/j.tiv.2017.04.009 10.1016/j.fct.2016.01.008 10.1016/j.neuro.2013.05.002 10.1016/j.chemosphere.2014.05.006 10.1002/tox.20154 10.1016/j.ejps.2017.03.037 10.1007/s10495-010-0554-0 10.1016/S0887-2333(01)00021-2 10.1007/BF00172811 10.1016/j.toxicon.2017.05.003 10.1002/jat.1546 10.1016/j.toxicon.2004.12.023 10.1016/j.bbrc.2016.12.101 10.5740/jaoacint.11-465 10.1007/s10544-017-0162-7 10.1016/S0041-0101(99)00216-0 10.1016/j.lfs.2011.12.021 10.1111/j.1527-3466.2007.00005.x 10.1093/carcin/11.7.1171 10.1016/j.mrfmmm.2010.05.004 10.1016/j.bios.2015.07.062 10.1016/j.tiv.2016.02.021 10.1016/0041-0101(96)00073-6 10.1101/cshperspect.a030288 10.1089/omi.2017.0108 10.1016/j.lfs.2017.03.022 10.1016/j.tiv.2011.09.014 10.1016/S0041-0101(00)00241-5 10.1007/s12035-014-8699-4 10.1016/j.marenvres.2017.11.004 10.1016/j.toxicon.2014.06.011 10.3390/toxins5010009 10.1016/j.toxlet.2017.12.003 10.1016/j.pbb.2011.08.019 10.1002/tox.20765 10.1016/j.chemosphere.2017.09.100 10.1111/j.1476-5381.2009.00512.x 10.1016/j.biortech.2014.12.019 10.3390/s91109414 |
| ContentType | Journal Article |
| Copyright | 2019 Elsevier Ltd Copyright © 2019 Elsevier Ltd. All rights reserved. |
| Copyright_xml | – notice: 2019 Elsevier Ltd – notice: Copyright © 2019 Elsevier Ltd. All rights reserved. |
| DBID | AAYXX CITATION NPM 7X8 7S9 L.6 |
| DOI | 10.1016/j.toxicon.2018.12.007 |
| DatabaseName | CrossRef PubMed MEDLINE - Academic AGRICOLA AGRICOLA - Academic |
| DatabaseTitle | CrossRef PubMed MEDLINE - Academic AGRICOLA AGRICOLA - Academic |
| DatabaseTitleList | AGRICOLA PubMed MEDLINE - Academic |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: 7X8 name: MEDLINE - Academic url: https://search.proquest.com/medline sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Anatomy & Physiology Pharmacy, Therapeutics, & Pharmacology |
| EISSN | 1879-3150 |
| EndPage | 7 |
| ExternalDocumentID | 30639658 10_1016_j_toxicon_2018_12_007 S0041010119300042 |
| Genre | Journal Article Review |
| GroupedDBID | --- --K --M -~X .~1 0R~ 123 1B1 1RT 1~. 1~5 4.4 457 4G. 5RE 5VS 7-5 71M 8P~ 9JM AABNK AACTN AAEDT AAEDW AAIAV AAIKJ AAKOC AALRI AAOAW AAQFI AATCM AAXUO ABFRF ABFYP ABGSF ABJNI ABLST ABMAC ABUDA ABYKQ ABZDS ACDAQ ACGFO ACGFS ACIUM ACRLP ADBBV ADEZE ADUVX AEBSH AEFWE AEHWI AEKER AENEX AFKWA AFTJW AFXIZ AGHFR AGUBO AGYEJ AHEUO AIEXJ AIKHN AITUG AJOXV AKIFW ALCLG ALMA_UNASSIGNED_HOLDINGS AMFUW AMRAJ AXJTR BKOJK BLECG BLXMC C45 CS3 DOVZS DU5 EBS EFJIC EFLBG EJD EO8 EO9 EP2 EP3 F5P FDB FIRID FNPLU FYGXN G-Q GBLVA IHE J1W KCYFY KOM M34 M41 MO0 N9A O-L O9- OAUVE OGGZJ OVD OZT P-8 P-9 P2P PC. Q38 RIG ROL RPZ SCC SDF SDG SDP SES SPCBC SSJ SSP SSU SSZ T5K TEORI TWZ ~02 ~G- .GJ 29Q 41~ 53G 9DU AAHBH AAQXK AATTM AAXKI AAYWO AAYXX ABFNM ABWVN ABXDB ACLOT ACRPL ACVFH ADCNI ADMUD ADNMO AEIPS AEUPX AFJKZ AFPUW AGQPQ AGRDE AHHHB AIGII AIIUN AKBMS AKRWK AKYEP ANKPU APXCP ASPBG AVWKF AZFZN CITATION EFKBS FEDTE FGOYB G-2 HMT HVGLF HZ~ R2- SEW SPT WUQ XOL Y6R ZGI ZXP ~HD ~KM NPM SSH 7X8 7S9 L.6 |
| ID | FETCH-LOGICAL-c424t-cdb49df314cd2a63da32c7c7e7840d0acb28eec1e177f76485f8a76990ac3e613 |
| ISICitedReferencesCount | 79 |
| ISICitedReferencesURI | http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000462420300001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| ISSN | 0041-0101 1879-3150 |
| IngestDate | Thu Oct 02 06:47:36 EDT 2025 Sat Sep 27 20:41:50 EDT 2025 Thu Apr 03 07:05:28 EDT 2025 Sat Nov 29 03:02:02 EST 2025 Tue Nov 18 21:45:14 EST 2025 Fri Feb 23 02:34:04 EST 2024 |
| IsPeerReviewed | true |
| IsScholarly | true |
| Keywords | Okadaic acid Protein phosphatase Diarrhetic shellfish poisoning Detection Detoxification |
| Language | English |
| License | Copyright © 2019 Elsevier Ltd. All rights reserved. |
| LinkModel | OpenURL |
| MergedId | FETCHMERGED-LOGICAL-c424t-cdb49df314cd2a63da32c7c7e7840d0acb28eec1e177f76485f8a76990ac3e613 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 ObjectType-Review-3 content type line 23 |
| PMID | 30639658 |
| PQID | 2179339320 |
| PQPubID | 23479 |
| PageCount | 7 |
| ParticipantIDs | proquest_miscellaneous_2220844228 proquest_miscellaneous_2179339320 pubmed_primary_30639658 crossref_citationtrail_10_1016_j_toxicon_2018_12_007 crossref_primary_10_1016_j_toxicon_2018_12_007 elsevier_sciencedirect_doi_10_1016_j_toxicon_2018_12_007 |
| PublicationCentury | 2000 |
| PublicationDate | 2019-03-15 |
| PublicationDateYYYYMMDD | 2019-03-15 |
| PublicationDate_xml | – month: 03 year: 2019 text: 2019-03-15 day: 15 |
| PublicationDecade | 2010 |
| PublicationPlace | England |
| PublicationPlace_xml | – name: England |
| PublicationTitle | Toxicon (Oxford) |
| PublicationTitleAlternate | Toxicon |
| PublicationYear | 2019 |
| Publisher | Elsevier Ltd |
| Publisher_xml | – name: Elsevier Ltd |
| References | Jayaraj, Gupta, Rao (bib30) 2009; 256 Thompson, MacGowan, Young, Colburn, Bowden (bib86) 2002; 62 Ikema, Takumi, Maeda, Kurimoto, Bohda, Chigwechokha, Sugiyama, Shiozaki, Furukawa, Komatsu (bib29) 2015; 83 Solter, Beasley (bib77) 2013 Ten-Hage, Delaunay, Pichon, Coute, Puiseux-Dao, Turquet (bib85) 2000; 38 Xing, Wang, Zhu, Zhou, Xu (bib103) 2009; 24 Le Berre, Kilcoyne, Kane (bib38) 2015; 103 Wang, Tung, Wang, Li, Iqbal, Grundke-Iqbal (bib96) 2001; 507 Harteneck, Frenzel, Kraft (bib24) 2007; 25 Danielsen, Hansen, Severinsen (bib14) 2014; 88 Zhang, Fang, Zou, Zou, Lang, Gao, Hu, Wang (bib106) 2016; 77 Pan, Wan, Zhong, Li, Wu, Wang, Wang (bib61) 2017; 19 Petroni, Tsai, Mondal, George (bib62) 2013; 28 Kolrep, Rein, Lampen, Hessel-Pras (bib36) 2017; 42 Solino, Sureda, Diogene (bib76) 2015; 29 Del Campo, Zhong, Tampe, Garcia, Lagos (bib15) 2017; 126 Opsahl, Ljostveit, Solstad, Risa, Roepstorff, Fladmark (bib58) 2013; 11 Rodrigues, Vale, Chaveca, Laires, Rueff, Oliveira (bib69) 2010; 30 Yasumoto (bib104) 1981; 31 Poole, Poole, Abraham (bib64) 1998; 798 Sivonen, Namikoshi, Evans, Fardig, Carmichael, Rinehart (bib74) 1992; 5 Heredia-Tapia, Arredondo-Vega, Nunez-Vazquez, Yasumoto, Yasuda, Ochoa (bib26) 2002; 40 McPartlin, Lochhead, Connell, Doucette, O'Kennedy (bib49) 2016; 60 Manita, Alves, Braga, Fogaca, Marques, Costa (bib45) 2017; 101 Rubiolo, Lopez-Alonso, Vega, Vieytes, Botana (bib70) 2012; 90 Ward, Spiers (bib100) 2017; 174 Nascimento, Purdie, Morris (bib54) 2005; 45 Cakir, Duzova, Tekin, Taslidere, Kaya, Cigremis, Ozgocer, Yologlu (bib8) 2017; 176 Chen (bib9) 2011; 25 Wu, Duan, Zhang, Wang (bib101) 2015; 407 McNamee, Medlin, Kegel, McCoy, Raine, Barra, Ruggiero, Kooistra, Montresor, Hagstrom, Blanco, Graneli, Rodriguez, Escalera, Reguera, Dittami, Edvardsen, Taylor, Lewis, Pazos, Elliott, Campbell (bib48) 2016; 55 Ferron, Hogeveen, De Sousa, Rahmani, Dubreil, Fessard, Le Hegarat (bib18) 2016; 33 Chi, Giri, Jun, Kim, Kim, Yun, Park (bib11) 2017; 65 Ozaki, Kohama, Nonomura, Shibata, Karaki (bib60) 1987; 335 Jiao, Dou, Wang, Li, Liu, Yang, Yang (bib31) 2017; 133 Wu, Kosaraju, Tam (bib102) 2017; 110 Smienk, Dominguez, Rodriguez-Velasco, Clarke, Kapp, Katikou, Cabado, Otero, Vieites, Razquin, Mata (bib75) 2013; 96 Suzuki, Quilliam (bib82) 2011; 27 Zhao, Xiao, Wang, Pei, Guan (bib107) 2016; 241 Della Loggia, Sosa, Tubaro (bib16) 1999; 7 Tubaro, Florio, Luxich, Vertua, Della Loggia, Yasumoto (bib87) 1996; 34 Lago, Santaclara, Vieites, Cabado (bib37) 2005; 46 Souid, Souayed, Haouas, Maaroufi (bib78) 2018; 144 Subramanian, Savanur, Madhavadas (bib80) 2017; 483 Vilarino, Fonfria, Louzao, Botana (bib95) 2009; 9 Oliveira, da Cruz, Muller, Martins, Cova, da Cruz, Henriques (bib56) 2017; 21 Shen, Luo, Li, Ting, He, Xu, Wang (bib72) 2018; 41 Bialojan, Takai (bib3) 1988; 256 Valdiglesias, Mendez, Pasaro, Cemeli, Anderson, Laffon (bib91) 2010; 689 Franchinia, Marchesini, Poletti, Ottaviani (bib21) 2005; 49 Takai, Murata, Torigoe, Isobe, Mieskes, Yasumoto (bib84) 1992; 284 Flanagan, Callanan, Donlon, Palmer, Forde, Kane (bib20) 2001; 39 Huang, Huang, Zhuang, Huang, Fu, Peng, Liu (bib27) 2013; 28 Matias, Bonini, Creppy (bib46) 1996; 48 Tachibana, Scheuer, Tsukitani, Kikuchi, Engen, Clardy, Gopichand, Schmitz (bib83) 1981; vol. 103 Valdiglesias, Laffon, Pasaro, Mendez (bib89) 2011; 74 Vieites, Leira, Botana, Vieytes (bib94) 1996; 70 Bouaicha, Hennion, Sandra (bib5) 1997; 35 Braga, Alves, Maulvault, Barbosa, Marques, Costa (bib6) 2016; 89 Christian, Luckas (bib12) 2008; 391 Mouratidou, Kaniou-Grigoriadou, Samara, Kouimtzis (bib51) 2006; 366 Prego-Faraldo, Valdiglesias, Mendez, Eirin-Lopez (bib67) 2013; 11 Louppis, Badeka, Katikou, Paleologos, Kontominas (bib44) 2010; 55 Prego-Faraldo, Valdiglesias, Laffon, Eirin-Lopez, Mendez (bib65) 2015; 78 Prego-Faraldo, Valdiglesias, Laffon, Mendez, Eirin-Lopez (bib66) 2016; 8 Cabado, Leira, Vieytes, Vieites, Botana (bib7) 2004; 78 Huynh-Delerme, Fessard, Kiefer-Biasizzo, Puiseux-Dao (bib28) 2003; 18 Wang, Sang, Wang (bib97) 2011; 94 Garcia, Oyaneder-Terrazas, Contreras, Del Campo, Torres, Contreras (bib23) 2016; 33 Kamat, Rai, Nath (bib32) 2013; 37 Yasumoto, Oshima, Yamaguchi (bib105) 1978; 44 Stewart, Hess, Connolly, Elliott (bib79) 2009; 81 Wang, Zeng, Yang, Zhong, Wang, Ling, Saeed, Yuan, Wang (bib98) 2017; 339 Li, Li, Chen, Shi, Zhang, Wang, Wang (bib43) 2014; 111 Murray, Rowan, McNamee, Campbell, Fogarty (bib52) 2018; 25 Fieber, Greer, Guo, Crawford, Rein (bib19) 2012; 24 Bacchiocchi, Siracusa, Ruzzi, Gorbi, Ercolessi, Cosentino, Ammazzalorso, Orletti (bib1) 2015; 108 Olivieri, Baysang, Meier, Muller-Spahn, Stahelin, Brockhaus, Brack (bib57) 2001; 76 Nam, Hiro, Kimura, Fujiki, Imanishi (bib53) 1990; 11 Turner, Goya (bib88) 2015; 102 Kodama, Kondo, Shibata (bib35) 1986; 378 Leira, Alvarez, Vieites, Vieytes, Botana (bib41) 2001; 15 Baker, Gotz (bib2) 2016; 4 Schmitz, Prasad, Gopichand, Hossain, Helm, Schmidt (bib71) 1981; 103 Mountfort, Kennedy, Garthwaite, Quilliam, Truman, Hannah (bib50) 1999; 37 Ravindran, Gupta, Agrawal, Bala Bhaskar, Lakshmana Rao (bib68) 2011; 16 Kamat, Tota, Shukla, Ali, Najmi, Nath (bib34) 2011; 100 Hayat, Barthelmebs, Sassolas, Marty (bib25) 2012; 724 Espina, Louzao, Cagide, Alfonso, Vieytes, Yasumoto, Botana (bib17) 2010; 159 Shibata (bib73) 1987; 24 Le Du, Tovar-Ramirez, Nunez-Vazquez (bib39) 2017; 190 Chen, Jiang (bib10) 2018; 284 Ciminiello, Dell'Aversano, Fattorusso, Forino, Magno, Santelia, Tsoukatou (bib13) 2006; 47 Ozaki, Ishihara, Kohama, Nonomura, Shibata, Karaki (bib59) 1987; 243 Wang, Chen, Li, Wang, Fu, Han, Zheng (bib99) 2015; 179 Kamat, Rai, Swarnkar, Shukla, Nath (bib33) 2014; 50 Suzuki (bib81) 2012; 5 Botelho, Vale, Joaquim, Costa, Soares, Roque, Matias (bib4) 2018; 190 Vdovenko, Hung, Sakharov, Yu (bib93) 2013; 116 Maurer, Fritz (bib47) 1990; 104 Fuster-Matanzo, Hernandez, Avila (bib22) 2018; 19 Leonardo, Toldra, Rambla-Alegre, Fernandez-Tejedor, Andree, Ferreres, Campbell, Elliott, O'Sullivan, Pazos, Diogene, Campas (bib42) 2018; 133 Le Hegarat, Jacquin, Bazin, Fessard (bib40) 2006; 21 Valdiglesias, Prego-Faraldo, Pasaro, Mendez, Laffon (bib92) 2013; 11 Valdiglesias, Laffon, Pasaro, Mendez (bib90) 2011; 13 Nuydens, de Jong, Van Den Kieboom, Heers, Dispersyn, Cornelissen, Nuyens, Borgers, Geerts (bib55) 1998; 70 Pollard, Goldman (bib63) 2018; 10 Chi (10.1016/j.toxicon.2018.12.007_bib11) 2017; 65 Del Campo (10.1016/j.toxicon.2018.12.007_bib15) 2017; 126 Opsahl (10.1016/j.toxicon.2018.12.007_bib58) 2013; 11 Takai (10.1016/j.toxicon.2018.12.007_bib84) 1992; 284 Wang (10.1016/j.toxicon.2018.12.007_bib98) 2017; 339 Stewart (10.1016/j.toxicon.2018.12.007_bib79) 2009; 81 Leonardo (10.1016/j.toxicon.2018.12.007_bib42) 2018; 133 Yasumoto (10.1016/j.toxicon.2018.12.007_bib105) 1978; 44 Manita (10.1016/j.toxicon.2018.12.007_bib45) 2017; 101 Chen (10.1016/j.toxicon.2018.12.007_bib9) 2011; 25 Heredia-Tapia (10.1016/j.toxicon.2018.12.007_bib26) 2002; 40 Ikema (10.1016/j.toxicon.2018.12.007_bib29) 2015; 83 Olivieri (10.1016/j.toxicon.2018.12.007_bib57) 2001; 76 Danielsen (10.1016/j.toxicon.2018.12.007_bib14) 2014; 88 Harteneck (10.1016/j.toxicon.2018.12.007_bib24) 2007; 25 Sivonen (10.1016/j.toxicon.2018.12.007_bib74) 1992; 5 Mouratidou (10.1016/j.toxicon.2018.12.007_bib51) 2006; 366 Pan (10.1016/j.toxicon.2018.12.007_bib61) 2017; 19 Vieites (10.1016/j.toxicon.2018.12.007_bib94) 1996; 70 Kodama (10.1016/j.toxicon.2018.12.007_bib35) 1986; 378 Ozaki (10.1016/j.toxicon.2018.12.007_bib60) 1987; 335 Thompson (10.1016/j.toxicon.2018.12.007_bib86) 2002; 62 Nuydens (10.1016/j.toxicon.2018.12.007_bib55) 1998; 70 Pollard (10.1016/j.toxicon.2018.12.007_bib63) 2018; 10 Zhang (10.1016/j.toxicon.2018.12.007_bib106) 2016; 77 Ciminiello (10.1016/j.toxicon.2018.12.007_bib13) 2006; 47 Nam (10.1016/j.toxicon.2018.12.007_bib53) 1990; 11 Kamat (10.1016/j.toxicon.2018.12.007_bib32) 2013; 37 Lago (10.1016/j.toxicon.2018.12.007_bib37) 2005; 46 Rodrigues (10.1016/j.toxicon.2018.12.007_bib69) 2010; 30 Della Loggia (10.1016/j.toxicon.2018.12.007_bib16) 1999; 7 Le Hegarat (10.1016/j.toxicon.2018.12.007_bib40) 2006; 21 Suzuki (10.1016/j.toxicon.2018.12.007_bib82) 2011; 27 Tubaro (10.1016/j.toxicon.2018.12.007_bib87) 1996; 34 Ferron (10.1016/j.toxicon.2018.12.007_bib18) 2016; 33 Franchinia (10.1016/j.toxicon.2018.12.007_bib21) 2005; 49 Prego-Faraldo (10.1016/j.toxicon.2018.12.007_bib65) 2015; 78 Braga (10.1016/j.toxicon.2018.12.007_bib6) 2016; 89 McPartlin (10.1016/j.toxicon.2018.12.007_bib49) 2016; 60 Poole (10.1016/j.toxicon.2018.12.007_bib64) 1998; 798 Valdiglesias (10.1016/j.toxicon.2018.12.007_bib91) 2010; 689 Wang (10.1016/j.toxicon.2018.12.007_bib97) 2011; 94 Wu (10.1016/j.toxicon.2018.12.007_bib101) 2015; 407 Fieber (10.1016/j.toxicon.2018.12.007_bib19) 2012; 24 Wang (10.1016/j.toxicon.2018.12.007_bib96) 2001; 507 Prego-Faraldo (10.1016/j.toxicon.2018.12.007_bib66) 2016; 8 Solter (10.1016/j.toxicon.2018.12.007_bib77) 2013 Turner (10.1016/j.toxicon.2018.12.007_bib88) 2015; 102 Garcia (10.1016/j.toxicon.2018.12.007_bib23) 2016; 33 Solino (10.1016/j.toxicon.2018.12.007_bib76) 2015; 29 Flanagan (10.1016/j.toxicon.2018.12.007_bib20) 2001; 39 Chen (10.1016/j.toxicon.2018.12.007_bib10) 2018; 284 Hayat (10.1016/j.toxicon.2018.12.007_bib25) 2012; 724 Cabado (10.1016/j.toxicon.2018.12.007_bib7) 2004; 78 Shen (10.1016/j.toxicon.2018.12.007_bib72) 2018; 41 Wu (10.1016/j.toxicon.2018.12.007_bib102) 2017; 110 Xing (10.1016/j.toxicon.2018.12.007_bib103) 2009; 24 Shibata (10.1016/j.toxicon.2018.12.007_bib73) 1987; 24 Botelho (10.1016/j.toxicon.2018.12.007_bib4) 2018; 190 Valdiglesias (10.1016/j.toxicon.2018.12.007_bib89) 2011; 74 Matias (10.1016/j.toxicon.2018.12.007_bib46) 1996; 48 Oliveira (10.1016/j.toxicon.2018.12.007_bib56) 2017; 21 Li (10.1016/j.toxicon.2018.12.007_bib43) 2014; 111 Tachibana (10.1016/j.toxicon.2018.12.007_bib83) 1981; vol. 103 Fuster-Matanzo (10.1016/j.toxicon.2018.12.007_bib22) 2018; 19 Maurer (10.1016/j.toxicon.2018.12.007_bib47) 1990; 104 Bialojan (10.1016/j.toxicon.2018.12.007_bib3) 1988; 256 Mountfort (10.1016/j.toxicon.2018.12.007_bib50) 1999; 37 Rubiolo (10.1016/j.toxicon.2018.12.007_bib70) 2012; 90 Valdiglesias (10.1016/j.toxicon.2018.12.007_bib90) 2011; 13 Cakir (10.1016/j.toxicon.2018.12.007_bib8) 2017; 176 Jayaraj (10.1016/j.toxicon.2018.12.007_bib30) 2009; 256 Leira (10.1016/j.toxicon.2018.12.007_bib41) 2001; 15 Christian (10.1016/j.toxicon.2018.12.007_bib12) 2008; 391 Jiao (10.1016/j.toxicon.2018.12.007_bib31) 2017; 133 Murray (10.1016/j.toxicon.2018.12.007_bib52) 2018; 25 Petroni (10.1016/j.toxicon.2018.12.007_bib62) 2013; 28 Schmitz (10.1016/j.toxicon.2018.12.007_bib71) 1981; 103 Ward (10.1016/j.toxicon.2018.12.007_bib100) 2017; 174 Ozaki (10.1016/j.toxicon.2018.12.007_bib59) 1987; 243 Yasumoto (10.1016/j.toxicon.2018.12.007_bib104) 1981; 31 Ravindran (10.1016/j.toxicon.2018.12.007_bib68) 2011; 16 Smienk (10.1016/j.toxicon.2018.12.007_bib75) 2013; 96 Ten-Hage (10.1016/j.toxicon.2018.12.007_bib85) 2000; 38 Le Du (10.1016/j.toxicon.2018.12.007_bib39) 2017; 190 Louppis (10.1016/j.toxicon.2018.12.007_bib44) 2010; 55 Suzuki (10.1016/j.toxicon.2018.12.007_bib81) 2012; 5 Bacchiocchi (10.1016/j.toxicon.2018.12.007_bib1) 2015; 108 Valdiglesias (10.1016/j.toxicon.2018.12.007_bib92) 2013; 11 Vilarino (10.1016/j.toxicon.2018.12.007_bib95) 2009; 9 Bouaicha (10.1016/j.toxicon.2018.12.007_bib5) 1997; 35 Prego-Faraldo (10.1016/j.toxicon.2018.12.007_bib67) 2013; 11 McNamee (10.1016/j.toxicon.2018.12.007_bib48) 2016; 55 Nascimento (10.1016/j.toxicon.2018.12.007_bib54) 2005; 45 Subramanian (10.1016/j.toxicon.2018.12.007_bib80) 2017; 483 Huang (10.1016/j.toxicon.2018.12.007_bib27) 2013; 28 Kamat (10.1016/j.toxicon.2018.12.007_bib34) 2011; 100 Vdovenko (10.1016/j.toxicon.2018.12.007_bib93) 2013; 116 Le Berre (10.1016/j.toxicon.2018.12.007_bib38) 2015; 103 Baker (10.1016/j.toxicon.2018.12.007_bib2) 2016; 4 Souid (10.1016/j.toxicon.2018.12.007_bib78) 2018; 144 Zhao (10.1016/j.toxicon.2018.12.007_bib107) 2016; 241 Espina (10.1016/j.toxicon.2018.12.007_bib17) 2010; 159 Wang (10.1016/j.toxicon.2018.12.007_bib99) 2015; 179 Huynh-Delerme (10.1016/j.toxicon.2018.12.007_bib28) 2003; 18 Kamat (10.1016/j.toxicon.2018.12.007_bib33) 2014; 50 Kolrep (10.1016/j.toxicon.2018.12.007_bib36) 2017; 42 |
| References_xml | – start-page: 1155 year: 2013 end-page: 1186 ident: bib77 article-title: Chapter 38 - phycotoxins publication-title: Haschek and Rousseaux's Handbook of Toxicologic Pathology – volume: 256 start-page: 118 year: 2009 end-page: 127 ident: bib30 article-title: Multiple signal transduction pathways in okadaic acid induced apoptosis in HeLa cells publication-title: Toxicology – volume: 103 start-page: 169 year: 2015 end-page: 175 ident: bib38 article-title: Generation of a panel of high affinity antibodies and development of a biosensor-based immunoassay for the detection of okadaic acid in shellfish publication-title: Toxicon – volume: 190 start-page: 166 year: 2018 end-page: 173 ident: bib4 article-title: Combined effect of temperature and nutritional regime on the elimination of the lipophilic toxin okadaic acid in the naturally contaminated wedge shell Donax trunculus publication-title: Chemosphere – volume: 83 start-page: 229 year: 2015 end-page: 236 ident: bib29 article-title: Okadaic acid is taken-up into the cells mediated by human hepatocytes transporter OATP1B3 publication-title: Food Chem. Toxicol. – volume: 339 start-page: 154 year: 2017 end-page: 160 ident: bib98 article-title: Detection of okadaic acid (OA) using ELISA and colloidal gold immunoassay based on monoclonal antibody publication-title: J. Hazard Mater. – volume: 18 start-page: 383 year: 2003 end-page: 394 ident: bib28 article-title: Characteristics of okadaic acid--induced cytotoxic effects in CHO K1 cells publication-title: Environ. Toxicol. – volume: 133 start-page: 74 year: 2017 end-page: 81 ident: bib31 article-title: Exposure of okadaic acid alters the angiogenesis in developing chick embryos publication-title: Toxicon – volume: 10 year: 2018 ident: bib63 article-title: Overview of the cytoskeleton from an evolutionary perspective publication-title: Cold Spring Harb. Perspect. Biol. – volume: 74 start-page: 980 year: 2011 end-page: 992 ident: bib89 article-title: Evaluation of okadaic acid-induced genotoxicity in human cells using the micronucleus test and gammaH2AX analysis publication-title: J. Toxicol. Environ. Health – volume: 44 start-page: 1249 year: 1978 end-page: 1255 ident: bib105 article-title: Occurrence of a new type of shellfish poisoning in the Tohoku district publication-title: Bull. Jpn. Soc. Sci. Fish. – volume: 55 start-page: 724 year: 2010 end-page: 733 ident: bib44 article-title: Determination of okadaic acid, dinophysistoxin-1 and related esters in Greek mussels using HPLC with fluorometric detection, LC-MS/MS and mouse bioassay publication-title: Toxicon – volume: 62 start-page: 3044 year: 2002 end-page: 3047 ident: bib86 article-title: A dominant negative c-jun specifically blocks okadaic acid-induced skin tumor promotion publication-title: Cancer Res. – volume: 46 start-page: 579 year: 2005 end-page: 586 ident: bib37 article-title: Collapse of mitochondrial membrane potential and caspases activation are early events in okadaic acid-treated Caco-2 cells publication-title: Toxicon – volume: 37 start-page: 163 year: 2013 end-page: 172 ident: bib32 article-title: Okadaic acid induced neurotoxicity: an emerging tool to study Alzheimer's disease pathology publication-title: Neurotoxicology – volume: 45 start-page: 633 year: 2005 end-page: 649 ident: bib54 article-title: Morphology, toxin composition and pigment content of Prorocentrum lima strains isolated from a coastal lagoon in southern UK publication-title: Toxicon – volume: 110 start-page: 101 year: 2017 end-page: 108 ident: bib102 article-title: SLM, a novel carbazole-based fluorophore attenuates okadaic acid-induced tau hyperphosphorylation via down-regulating GSK-3 beta activity in SH-SY5Y cells publication-title: Eur. J. Pharm. Sci. – volume: 39 start-page: 1021 year: 2001 end-page: 1027 ident: bib20 article-title: A cytotoxicity assay for the detection and differentiation of two families of shellfish toxins publication-title: Toxicon – volume: 284 start-page: 539 year: 1992 end-page: 544 ident: bib84 article-title: Inhibitory effect of okadaic acid derivatives on protein phosphatases. A study on structure-affinity relationship publication-title: Biochem. J. – volume: 798 start-page: 207 year: 1998 end-page: 222 ident: bib64 article-title: Recommendations for the determination of selectivity in micellar electrokinetic chromatography publication-title: J. Chromatogr. A – volume: 7 start-page: 387 year: 1999 end-page: 391 ident: bib16 article-title: Methodological improvement of the protein phosphatase inhibition assay for the detection of okadaic acid in mussels publication-title: Nat. Toxins – volume: 55 start-page: 112 year: 2016 end-page: 120 ident: bib48 article-title: Distribution, occurrence and biotoxin composition of the main shellfish toxin producing microalgae within European waters: a comparison of methods of analysis publication-title: Harmful Algae – volume: 190 start-page: 210 year: 2017 end-page: 216 ident: bib39 article-title: Embryotoxic effects of dissolved okadaic acid on the development of Longfin yellowtail Seriola rivoliana publication-title: Aquat. Toxicol. – volume: 133 start-page: 6 year: 2018 end-page: 14 ident: bib42 article-title: Self-assembled monolayer-based immunoassays for okadaic acid detection in seawater as monitoring tools publication-title: Mar. Environ. Res. – volume: 38 start-page: 1043 year: 2000 end-page: 1054 ident: bib85 article-title: Okadaic acid production from the marine benthic dinoflagellate Prorocentrum arenarium Faust (Dinophyceae) isolated from Europa Island coral reef ecosystem (SW Indian Ocean) publication-title: Toxicon – volume: 8 year: 2016 ident: bib66 article-title: Early genotoxic and cytotoxic effects of the toxic dinoflagellate Prorocentrum lima in the mussel Mytilus galloprovincialis publication-title: Toxins – volume: 24 start-page: 104 year: 1987 end-page: 107 ident: bib73 article-title: Unique vasocontraction of okadaic acid isolated from black sponge, independent of extracellular Ca2+ publication-title: Blood Vessel. – volume: 176 start-page: 10 year: 2017 end-page: 20 ident: bib8 article-title: ACA, an inhibitor phospholipases A2 and transient receptor potential melastatin-2 channels, attenuates okadaic acid induced neurodegeneration in rats publication-title: Life Sci. – volume: 11 start-page: 1763 year: 2013 end-page: 1782 ident: bib58 article-title: Identification of dynamic changes in proteins associated with the cellular cytoskeleton after exposure to okadaic acid publication-title: Mar. Drugs – volume: 34 start-page: 965 year: 1996 end-page: 974 ident: bib87 article-title: Suitability of the MTT-based cytotoxicity assay to detect okadaic acid contamination of mussels publication-title: Toxicon – volume: 11 start-page: 4328 year: 2013 end-page: 4349 ident: bib92 article-title: Okadaic acid: more than a diarrheic toxin publication-title: Mar. Drugs – volume: 48 start-page: 309 year: 1996 end-page: 317 ident: bib46 article-title: Inhibition of protein synthesis in a cell-free system and Vero cells by okadaic acid, a diarrhetic shellfish toxin publication-title: J. Toxicol. Environ. Health – volume: 49 start-page: 179 year: 2005 end-page: 188 ident: bib21 article-title: Swiss mice CD1 fed on mussels contaminated by okadaic acid and yessotoxins: effects on thymus and spleen publication-title: Eur. J. Histochem. – volume: 19 year: 2018 ident: bib22 article-title: Tau spreading mechanisms; implications for dysfunctional tauopathies publication-title: Int. J. Mol. Sci. – volume: 31 start-page: 515 year: 1981 end-page: 522 ident: bib104 article-title: Method for the bioassay of diarrhetic shellfish toxin (in Japanese) publication-title: Food Sanit, Res. – volume: 19 start-page: 33 year: 2017 end-page: 39 ident: bib61 article-title: Label-free okadaic acid detection using growth of gold nanoparticles in sensor gaps as a conductive tag publication-title: Biomed. Microdevices – volume: 126 start-page: 23 year: 2017 end-page: 31 ident: bib15 article-title: Sublethal doses of dinophysistoxin-1 and okadaic acid stimulate secretion of inflammatory factors on innate immune cells: negative health consequences publication-title: Toxicon – volume: 16 start-page: 145 year: 2011 end-page: 161 ident: bib68 article-title: Modulation of ROS/MAPK signaling pathways by okadaic acid leads to cell death via, mitochondrial mediated caspase-dependent mechanism publication-title: Apoptosis – volume: 391 start-page: 117 year: 2008 end-page: 134 ident: bib12 article-title: Determination of marine biotoxins relevant for regulations: from the mouse bioassay to coupled LC-MS methods publication-title: Anal. Bioanal. Chem. – volume: 30 start-page: 699 year: 2010 end-page: 707 ident: bib69 article-title: Naturally contaminated shellfish samples: quantification of diarrhetic shellfish poisoning toxins in unhydrolysed and hydrolysed extracts and cytotoxicity assessment publication-title: J. Appl. Toxicol. – volume: 335 start-page: 356 year: 1987 end-page: 358 ident: bib60 article-title: Direct activation by okadaic acid of the contractile elements in the smooth muscle of Guinea-pig taenia coli publication-title: Naunyn-Schmiedeberg’s Arch. Pharmacol. – volume: 65 start-page: 111 year: 2017 end-page: 117 ident: bib11 article-title: Effects of algal toxin okadaic acid on the non-specific immune and antioxidant response of bay scallop (Argopecten irradians) publication-title: Fish Shellfish Immunol. – volume: 159 start-page: 337 year: 2010 end-page: 344 ident: bib17 article-title: The methyl ester of okadaic acid is more potent than okadaic acid in disrupting the actin cytoskeleton and metabolism of primary cultured hepatocytes publication-title: Br. J. Pharmacol. – volume: 100 start-page: 311 year: 2011 end-page: 319 ident: bib34 article-title: Mitochondrial dysfunction: a crucial event in okadaic acid (ICV) induced memory impairment and apoptotic cell death in rat brain publication-title: Pharmacol. Biochem. Behav. – volume: 13 start-page: 1831 year: 2011 end-page: 1840 ident: bib90 article-title: Okadaic acid induces morphological changes, apoptosis and cell cycle alterations in different human cell types publication-title: J. Environ. Monit. – volume: vol. 103 start-page: 2469 year: 1981 end-page: 2471 ident: bib83 publication-title: Okadaic Acid, a Cytotoxicity Polyether from Two Marine Sponges of the Genus Halichondria – volume: 88 start-page: 77 year: 2014 end-page: 87 ident: bib14 article-title: Okadaic acid: a rapid inducer of lamellar bodies in small intestinal enterocytes publication-title: Toxicon – volume: 94 start-page: 1531 year: 2011 end-page: 1539 ident: bib97 article-title: Enzyme-linked immunosorbent assay for okadaic acid: investigation of analytical conditions and sample matrix on assay performance publication-title: J. AOAC Int. – volume: 33 start-page: 136 year: 2016 end-page: 146 ident: bib18 article-title: Modulation of CYP3A4 activity alters the cytotoxicity of lipophilic phycotoxins in human hepatic HepaRG cells publication-title: Toxicol. Vitro – volume: 70 start-page: 440 year: 1996 end-page: 443 ident: bib94 article-title: Determination of DSP toxins: comparative study of HPLC and bioassay to reduce the observation time of the mouse bioassay publication-title: Arch. Toxicol. – volume: 483 start-page: 585 year: 2017 end-page: 589 ident: bib80 article-title: Passive immunization targeting the N-terminal region of phosphorylated tau (residues 68-71) improves spatial memory in okadaic acid induced tauopathy model rats publication-title: Biochem. Biophys. Res. Commun. – volume: 144 start-page: 55 year: 2018 end-page: 60 ident: bib78 article-title: Does the phycotoxin Okadaic acid cause oxidative stress damages and histological alterations to seabream (Sparus aurata)? publication-title: Toxicon – volume: 24 start-page: 437 year: 2009 end-page: 445 ident: bib103 article-title: Morphological and biochemical changes associated with apoptosis induced by okadaic acid in human amniotic FL cells publication-title: Environ. Toxicol. – volume: 89 start-page: 54 year: 2016 end-page: 59 ident: bib6 article-title: In vitro bioaccessibility of the marine biotoxin okadaic acid in shellfish publication-title: Food Chem. Toxicol. – volume: 25 start-page: 1796 year: 2011 end-page: 1802 ident: bib9 article-title: Okadaic acid induces apoptosis through the PKR, NF-kappaB and caspase pathway in human osteoblastic osteosarcoma MG63 cells publication-title: Toxicol. Vitro – volume: 116 start-page: 343 year: 2013 end-page: 346 ident: bib93 article-title: Determination of okadaic acid in shellfish by using a novel chemiluminescent enzyme-linked immunosorbent assay method publication-title: Talanta – volume: 28 start-page: 700 year: 2013 end-page: 706 ident: bib62 article-title: Attenuation of low dose methylmercury and glutamate induced-cytotoxicity and tau phosphorylation by an N-methyl-D-aspartate antagonist in human neuroblastoma (SHSY5Y) cells publication-title: Environ. Toxicol. – volume: 256 start-page: 283 year: 1988 end-page: 290 ident: bib3 article-title: Inhibitory effect of a marine-sponge toxin, okadaic acid, on protein phosphatases. Specificity and kinetics publication-title: Biochem. J. – volume: 5 start-page: 464 year: 1992 end-page: 469 ident: bib74 article-title: Three new microcystins, cyclic heptapeptide hepatotoxins, from Nostoc sp. strain 152 publication-title: Chem. Res. Toxicol. – volume: 102 start-page: 32 year: 2015 end-page: 42 ident: bib88 article-title: Occurrence and profiles of lipophilic toxins in shellfish harvested from Argentina publication-title: Toxicon – volume: 40 start-page: 1121 year: 2002 end-page: 1127 ident: bib26 article-title: Isolation of Prorocentrum lima (Syn. Exuviaella lima) and diarrhetic shellfish poisoning (DSP) risk assessment in the Gulf of California, Mexico publication-title: Toxicon – volume: 103 start-page: 2467 year: 1981 end-page: 2469 ident: bib71 article-title: Acanthifolicin, a new episufide-containing polyether carboxylic acid from extracts of the marine sponge Pandaros acanthifolium publication-title: J. Am. Chem. Soc. – volume: 28 start-page: 98 year: 2013 end-page: 106 ident: bib27 article-title: Study of cytoskeletal changes induced by okadaic acid in HL-7702 liver cells and development of a fluorimetric microplate assay for detecting diarrhetic shellfish poisoning publication-title: Environ. Toxicol. – volume: 689 start-page: 74 year: 2010 end-page: 79 ident: bib91 article-title: Assessment of okadaic acid effects on cytotoxicity, DNA damage and DNA repair in human cells publication-title: Mutat. Res. – volume: 11 start-page: 2829 year: 2013 end-page: 2845 ident: bib67 article-title: Okadaic acid meet and greet: an insight into detection methods, response strategies and genotoxic effects in marine invertebrates publication-title: Mar. Drugs – volume: 179 start-page: 243 year: 2015 end-page: 248 ident: bib99 article-title: Cultivation of the benthic microalga Prorocentrum lima for the production of diarrhetic shellfish poisoning toxins in a vertical flat photobioreactor publication-title: Bioresour. Technol. – volume: 21 start-page: 55 year: 2006 end-page: 64 ident: bib40 article-title: Genotoxicity of the marine toxin okadaic acid, in human Caco-2 cells and in mice gut cells publication-title: Environ. Toxicol. – volume: 11 start-page: 1171 year: 1990 end-page: 1174 ident: bib53 article-title: Permeability of a non-TPA-type tumor promoter, okadaic acid, through lipid bilayer membrane publication-title: Carcinogenesis – volume: 27 start-page: 571 year: 2011 end-page: 584 ident: bib82 article-title: LC-MS/MS analysis of diarrhetic shellfish poisoning (DSP) toxins, okadaic acid and dinophysistoxin analogues, and other lipophilic toxins publication-title: Anal. Sci. – volume: 35 start-page: 273 year: 1997 end-page: 281 ident: bib5 article-title: Determination of okadaic acid by micellar electrokinetic chromatography with ultraviolet detection publication-title: Toxicon – volume: 37 start-page: 909 year: 1999 end-page: 922 ident: bib50 article-title: Evaluation of the fluorometric protein phosphatase inhibition assay in the determination of okadaic acid in mussels publication-title: Toxicon – volume: 70 start-page: 1124 year: 1998 end-page: 1133 ident: bib55 article-title: Okadaic acid-induced apoptosis in neuronal cells: evidence for an abortive mitotic attempt publication-title: J. Neurochem. – volume: 108 start-page: 115 year: 2015 end-page: 125 ident: bib1 article-title: Two-year study of lipophilic marine toxin profile in mussels of the North-central Adriatic Sea: first report of azaspiracids in Mediterranean seafood publication-title: Toxicon – volume: 9 start-page: 9414 year: 2009 end-page: 9443 ident: bib95 article-title: Use of biosensors as alternatives to current regulatory methods for marine biotoxins publication-title: Sensors – volume: 5 start-page: 9 year: 2012 end-page: 15 ident: bib81 article-title: Differences in susceptibility to okadaic acid, a diarrhetic shellfish poisoning toxin, between male and female mice publication-title: Toxins – volume: 77 start-page: 573 year: 2016 end-page: 579 ident: bib106 article-title: A novel sensitive cell-based Love Wave biosensor for marine toxin detection publication-title: Biosens. Bioelectron. – volume: 50 start-page: 852 year: 2014 end-page: 865 ident: bib33 article-title: Molecular and cellular mechanism of okadaic acid (OKA)-induced neurotoxicity: a novel tool for Alzheimer's disease therapeutic application publication-title: Mol. Neurobiol. – volume: 76 start-page: 224 year: 2001 end-page: 233 ident: bib57 article-title: N-acetyl-L-cysteine protects SHSY5Y neuroblastoma cells from oxidative stress and cell cytotoxicity: effects on beta-amyloid secretion and tau phosphorylation publication-title: J. Neurochem. – volume: 111 start-page: 560 year: 2014 end-page: 567 ident: bib43 article-title: Detection, occurrence and monthly variations of typical lipophilic marine toxins associated with diarrhetic shellfish poisoning in the coastal seawater of Qingdao City, China publication-title: Chemosphere – volume: 407 start-page: 1303 year: 2015 end-page: 1312 ident: bib101 article-title: Simultaneous detection of microcysin-LR and okadaic acid using a dual fluorescence resonance energy transfer aptasensor publication-title: Anal. Bioanal. Chem. – volume: 78 start-page: 74 year: 2004 end-page: 85 ident: bib7 article-title: Cytoskeletal disruption is the key factor that triggers apoptosis in okadaic acid-treated neuroblastoma cells publication-title: Arch. Toxicol. – volume: 243 start-page: 1167 year: 1987 end-page: 1173 ident: bib59 article-title: Calcium-independent phosphorylation of smooth muscle myosin light chain by okadaic acid isolated from black sponge (Halichondria okadai) publication-title: J. Pharmacol. Exp. Therapeut. – volume: 378 start-page: 359 year: 1986 end-page: 373 ident: bib35 article-title: Electromechanical effects of okadaic acid isolated from black sponge in Guinea-pig ventricular muscles publication-title: J. Physiol. – volume: 33 start-page: 1711 year: 2016 end-page: 1727 ident: bib23 article-title: Determination of the toxic variability of lipophilic biotoxins in marine bivalve and gastropod tissues treated with an industrial canning process publication-title: Food Addit. Contam. Part A Chem. Anal. Control Expo. Risk Assess. – volume: 4 start-page: 32 year: 2016 ident: bib2 article-title: A local insult of okadaic acid in wild-type mice induces tau phosphorylation and protein aggregation in anatomically distinct brain regions publication-title: Acta Neuropathol. Commun. – volume: 41 start-page: 1138 year: 2018 end-page: 1146 ident: bib72 article-title: Quercetin inhibits okadaic acid-induced tau protein hyperphosphorylation through the Ca2+calpainp25CDK5 pathway in HT22 cells publication-title: Int. J. Mol. Med. – volume: 60 start-page: 49 year: 2016 end-page: 58 ident: bib49 article-title: Use of biosensors for the detection of marine toxins publication-title: Essays Biochem. – volume: 24 start-page: 1805 year: 2012 end-page: 1821 ident: bib19 article-title: Gene expression profiling of human liver carcinoma (HepG2) cells exposed to the marine toxin okadaic acid publication-title: Toxicol. Environ. Chem. – volume: 366 start-page: 894 year: 2006 end-page: 904 ident: bib51 article-title: Detection of the marine toxin okadaic acid in mussels during a diarrhetic shellfish poisoning (DSP) episode in Thermaikos Gulf, Greece, using biological, chemical and immunological methods publication-title: Sci. Total Environ. – volume: 25 start-page: 61 year: 2007 end-page: 75 ident: bib24 article-title: N-(p-amylcinnamoyl)anthranilic acid (ACA): a phospholipase A(2) inhibitor and TRP channel blocker publication-title: Cardiovasc. Drug Rev. – volume: 21 start-page: 550 year: 2017 end-page: 563 ident: bib56 article-title: Toward neuroproteomics in biological psychiatry: a systems approach unravels okadaic acid-induced alterations in the neuronal phosphoproteome publication-title: OMICS – volume: 96 start-page: 77 year: 2013 end-page: 85 ident: bib75 article-title: Quantitative determination of the okadaic acid toxins group by a colorimetric phosphatase inhibition assay: interlaboratory study publication-title: J. AOAC Int. – volume: 174 start-page: 1116 year: 2017 end-page: 1130 ident: bib100 article-title: Protein phosphatase 2A regulation of markers of extracellular matrix remodelling in hepatocellular carcinoma cells: functional consequences for tumour invasion publication-title: Br. J. Pharmacol. – volume: 29 start-page: 59 year: 2015 end-page: 62 ident: bib76 article-title: Evaluation of okadaic acid, dinophysistoxin-1 and dinophysistoxin-2 toxicity on Neuro-2a, NG108-15 and MCF-7 cell lines publication-title: Toxicol. Vitro – volume: 284 start-page: 96 year: 2018 end-page: 102 ident: bib10 article-title: Maduramicin-activated protein phosphatase 2A results in extracellular signal-regulated kinase 1/2 inhibition, leading to cytotoxicity in myocardial H9c2 cells publication-title: Toxicol. Lett. – volume: 25 start-page: 607 year: 2018 end-page: 614 ident: bib52 article-title: Pulsed light reduces the toxicity of the algal toxin okadaic acid to freshwater crustacean Daphnia pulex publication-title: Environ. Sci. Pollut. Res. Int. – volume: 241 start-page: 1825 year: 2016 end-page: 1833 ident: bib107 article-title: Influence of okadaic acid on hyperphosphorylation of tau and nicotinic acetylcholine receptors in primary neurons publication-title: Exp. Biol. Med. – volume: 724 start-page: 92 year: 2012 end-page: 97 ident: bib25 article-title: Development of a novel label-free amperometric immunosensor for the detection of okadaic acid publication-title: Anal. Chim. Acta – volume: 90 start-page: 416 year: 2012 end-page: 423 ident: bib70 article-title: Comparative study of toxicological and cell cycle effects of okadaic acid and dinophysistoxin-2 in primary rat hepatocytes publication-title: Life Sci. – volume: 81 start-page: 10208 year: 2009 end-page: 10214 ident: bib79 article-title: Development and single-laboratory validation of a pseudofunctional biosensor immunoassay for the detection of the okadaic acid group of toxins publication-title: Anal. Chem. – volume: 101 start-page: 121 year: 2017 end-page: 127 ident: bib45 article-title: In vitro bioaccessibility of the marine biotoxins okadaic acid, dinophysistoxin-2 and their 7-O-acyl fatty acid ester derivatives in raw and steamed shellfish publication-title: Food Chem. Toxicol. – volume: 104 start-page: 43 year: 1990 end-page: 46 ident: bib47 article-title: Toxicological detection of pholcodine and its metabolites in urine and hair using radio immunoassay, fluorescence polarisation immunoassay, enzyme immunoassay, and gas chromatography-mass spectrometry publication-title: Int. J. Leg. Med. – volume: 78 start-page: 814 year: 2015 end-page: 824 ident: bib65 article-title: In vitro analysis of early genotoxic and cytotoxic effects of okadaic acid in different cell types of the mussel Mytilus galloprovincialis publication-title: J. Toxicol. Environ. Health – volume: 47 start-page: 174 year: 2006 end-page: 181 ident: bib13 article-title: Investigation of the toxin profile of Greek mussels Mytilus galloprovincialis by liquid chromatography-mass spectrometry publication-title: Toxicon – volume: 42 start-page: 161 year: 2017 end-page: 170 ident: bib36 article-title: Metabolism of okadaic acid by NADPH-dependent enzymes present in human or rat liver S9 fractions results in different toxic effects publication-title: Toxicol. Vitro – volume: 507 start-page: 81 year: 2001 end-page: 87 ident: bib96 article-title: Hyperphosphorylation and accumulation of neurofilament proteins in Alzheimer disease brain and in okadaic acid-treated SY5Y cells publication-title: FEBS Lett. – volume: 15 start-page: 277 year: 2001 end-page: 282 ident: bib41 article-title: Study of cytoskeletal changes induced by okadaic acid in BE(2)-M17 cells by means of a quantitative fluorimetric microplate assay publication-title: Toxicol. Vitro – volume: 103 start-page: 169 year: 2015 ident: 10.1016/j.toxicon.2018.12.007_bib38 article-title: Generation of a panel of high affinity antibodies and development of a biosensor-based immunoassay for the detection of okadaic acid in shellfish publication-title: Toxicon doi: 10.1016/j.toxicon.2015.06.030 – volume: 391 start-page: 117 year: 2008 ident: 10.1016/j.toxicon.2018.12.007_bib12 article-title: Determination of marine biotoxins relevant for regulations: from the mouse bioassay to coupled LC-MS methods publication-title: Anal. Bioanal. Chem. doi: 10.1007/s00216-007-1778-x – volume: 28 start-page: 98 year: 2013 ident: 10.1016/j.toxicon.2018.12.007_bib27 article-title: Study of cytoskeletal changes induced by okadaic acid in HL-7702 liver cells and development of a fluorimetric microplate assay for detecting diarrhetic shellfish poisoning publication-title: Environ. Toxicol. doi: 10.1002/tox.20702 – volume: 4 start-page: 32 year: 2016 ident: 10.1016/j.toxicon.2018.12.007_bib2 article-title: A local insult of okadaic acid in wild-type mice induces tau phosphorylation and protein aggregation in anatomically distinct brain regions publication-title: Acta Neuropathol. Commun. doi: 10.1186/s40478-016-0300-0 – volume: 13 start-page: 1831 year: 2011 ident: 10.1016/j.toxicon.2018.12.007_bib90 article-title: Okadaic acid induces morphological changes, apoptosis and cell cycle alterations in different human cell types publication-title: J. Environ. Monit. doi: 10.1039/c0em00771d – volume: 108 start-page: 115 year: 2015 ident: 10.1016/j.toxicon.2018.12.007_bib1 article-title: Two-year study of lipophilic marine toxin profile in mussels of the North-central Adriatic Sea: first report of azaspiracids in Mediterranean seafood publication-title: Toxicon doi: 10.1016/j.toxicon.2015.10.002 – volume: 35 start-page: 273 year: 1997 ident: 10.1016/j.toxicon.2018.12.007_bib5 article-title: Determination of okadaic acid by micellar electrokinetic chromatography with ultraviolet detection publication-title: Toxicon doi: 10.1016/S0041-0101(96)00069-4 – volume: 74 start-page: 980 year: 2011 ident: 10.1016/j.toxicon.2018.12.007_bib89 article-title: Evaluation of okadaic acid-induced genotoxicity in human cells using the micronucleus test and gammaH2AX analysis publication-title: J. Toxicol. Environ. Health doi: 10.1080/15287394.2011.582026 – volume: 37 start-page: 909 year: 1999 ident: 10.1016/j.toxicon.2018.12.007_bib50 article-title: Evaluation of the fluorometric protein phosphatase inhibition assay in the determination of okadaic acid in mussels publication-title: Toxicon doi: 10.1016/S0041-0101(98)00222-0 – volume: 40 start-page: 1121 year: 2002 ident: 10.1016/j.toxicon.2018.12.007_bib26 article-title: Isolation of Prorocentrum lima (Syn. Exuviaella lima) and diarrhetic shellfish poisoning (DSP) risk assessment in the Gulf of California, Mexico publication-title: Toxicon doi: 10.1016/S0041-0101(02)00111-3 – volume: 19 year: 2018 ident: 10.1016/j.toxicon.2018.12.007_bib22 article-title: Tau spreading mechanisms; implications for dysfunctional tauopathies publication-title: Int. J. Mol. Sci. doi: 10.3390/ijms19030645 – volume: 25 start-page: 607 year: 2018 ident: 10.1016/j.toxicon.2018.12.007_bib52 article-title: Pulsed light reduces the toxicity of the algal toxin okadaic acid to freshwater crustacean Daphnia pulex publication-title: Environ. Sci. Pollut. Res. Int. doi: 10.1007/s11356-017-0472-6 – volume: 104 start-page: 43 year: 1990 ident: 10.1016/j.toxicon.2018.12.007_bib47 article-title: Toxicological detection of pholcodine and its metabolites in urine and hair using radio immunoassay, fluorescence polarisation immunoassay, enzyme immunoassay, and gas chromatography-mass spectrometry publication-title: Int. J. Leg. Med. doi: 10.1007/BF01816483 – volume: 8 year: 2016 ident: 10.1016/j.toxicon.2018.12.007_bib66 article-title: Early genotoxic and cytotoxic effects of the toxic dinoflagellate Prorocentrum lima in the mussel Mytilus galloprovincialis publication-title: Toxins doi: 10.3390/toxins8060159 – volume: 724 start-page: 92 year: 2012 ident: 10.1016/j.toxicon.2018.12.007_bib25 article-title: Development of a novel label-free amperometric immunosensor for the detection of okadaic acid publication-title: Anal. Chim. Acta doi: 10.1016/j.aca.2012.02.035 – volume: 78 start-page: 74 year: 2004 ident: 10.1016/j.toxicon.2018.12.007_bib7 article-title: Cytoskeletal disruption is the key factor that triggers apoptosis in okadaic acid-treated neuroblastoma cells publication-title: Arch. Toxicol. doi: 10.1007/s00204-003-0505-4 – volume: 24 start-page: 1805 year: 2012 ident: 10.1016/j.toxicon.2018.12.007_bib19 article-title: Gene expression profiling of human liver carcinoma (HepG2) cells exposed to the marine toxin okadaic acid publication-title: Toxicol. Environ. Chem. doi: 10.1080/02772248.2012.730199 – volume: 46 start-page: 579 year: 2005 ident: 10.1016/j.toxicon.2018.12.007_bib37 article-title: Collapse of mitochondrial membrane potential and caspases activation are early events in okadaic acid-treated Caco-2 cells publication-title: Toxicon doi: 10.1016/j.toxicon.2005.07.007 – volume: 31 start-page: 515 year: 1981 ident: 10.1016/j.toxicon.2018.12.007_bib104 article-title: Method for the bioassay of diarrhetic shellfish toxin (in Japanese) publication-title: Food Sanit, Res. – volume: 76 start-page: 224 year: 2001 ident: 10.1016/j.toxicon.2018.12.007_bib57 article-title: N-acetyl-L-cysteine protects SHSY5Y neuroblastoma cells from oxidative stress and cell cytotoxicity: effects on beta-amyloid secretion and tau phosphorylation publication-title: J. Neurochem. doi: 10.1046/j.1471-4159.2001.00090.x – volume: 65 start-page: 111 year: 2017 ident: 10.1016/j.toxicon.2018.12.007_bib11 article-title: Effects of algal toxin okadaic acid on the non-specific immune and antioxidant response of bay scallop (Argopecten irradians) publication-title: Fish Shellfish Immunol. doi: 10.1016/j.fsi.2017.03.031 – volume: 798 start-page: 207 year: 1998 ident: 10.1016/j.toxicon.2018.12.007_bib64 article-title: Recommendations for the determination of selectivity in micellar electrokinetic chromatography publication-title: J. Chromatogr. A doi: 10.1016/S0021-9673(97)01164-3 – volume: 70 start-page: 440 year: 1996 ident: 10.1016/j.toxicon.2018.12.007_bib94 article-title: Determination of DSP toxins: comparative study of HPLC and bioassay to reduce the observation time of the mouse bioassay publication-title: Arch. Toxicol. doi: 10.1007/s002040050296 – volume: 256 start-page: 283 year: 1988 ident: 10.1016/j.toxicon.2018.12.007_bib3 article-title: Inhibitory effect of a marine-sponge toxin, okadaic acid, on protein phosphatases. Specificity and kinetics publication-title: Biochem. J. doi: 10.1042/bj2560283 – volume: 11 start-page: 2829 year: 2013 ident: 10.1016/j.toxicon.2018.12.007_bib67 article-title: Okadaic acid meet and greet: an insight into detection methods, response strategies and genotoxic effects in marine invertebrates publication-title: Mar. Drugs doi: 10.3390/md11082829 – volume: 49 start-page: 179 year: 2005 ident: 10.1016/j.toxicon.2018.12.007_bib21 article-title: Swiss mice CD1 fed on mussels contaminated by okadaic acid and yessotoxins: effects on thymus and spleen publication-title: Eur. J. Histochem. – volume: 70 start-page: 1124 year: 1998 ident: 10.1016/j.toxicon.2018.12.007_bib55 article-title: Okadaic acid-induced apoptosis in neuronal cells: evidence for an abortive mitotic attempt publication-title: J. Neurochem. doi: 10.1046/j.1471-4159.1998.70031124.x – volume: 29 start-page: 59 year: 2015 ident: 10.1016/j.toxicon.2018.12.007_bib76 article-title: Evaluation of okadaic acid, dinophysistoxin-1 and dinophysistoxin-2 toxicity on Neuro-2a, NG108-15 and MCF-7 cell lines publication-title: Toxicol. Vitro doi: 10.1016/j.tiv.2014.09.002 – volume: 256 start-page: 118 year: 2009 ident: 10.1016/j.toxicon.2018.12.007_bib30 article-title: Multiple signal transduction pathways in okadaic acid induced apoptosis in HeLa cells publication-title: Toxicology doi: 10.1016/j.tox.2008.11.013 – volume: 18 start-page: 383 year: 2003 ident: 10.1016/j.toxicon.2018.12.007_bib28 article-title: Characteristics of okadaic acid--induced cytotoxic effects in CHO K1 cells publication-title: Environ. Toxicol. doi: 10.1002/tox.10140 – volume: 55 start-page: 112 year: 2016 ident: 10.1016/j.toxicon.2018.12.007_bib48 article-title: Distribution, occurrence and biotoxin composition of the main shellfish toxin producing microalgae within European waters: a comparison of methods of analysis publication-title: Harmful Algae doi: 10.1016/j.hal.2016.02.008 – volume: 94 start-page: 1531 year: 2011 ident: 10.1016/j.toxicon.2018.12.007_bib97 article-title: Enzyme-linked immunosorbent assay for okadaic acid: investigation of analytical conditions and sample matrix on assay performance publication-title: J. AOAC Int. doi: 10.5740/jaoacint.10-412 – volume: 190 start-page: 210 year: 2017 ident: 10.1016/j.toxicon.2018.12.007_bib39 article-title: Embryotoxic effects of dissolved okadaic acid on the development of Longfin yellowtail Seriola rivoliana publication-title: Aquat. Toxicol. doi: 10.1016/j.aquatox.2017.07.012 – volume: 378 start-page: 359 year: 1986 ident: 10.1016/j.toxicon.2018.12.007_bib35 article-title: Electromechanical effects of okadaic acid isolated from black sponge in Guinea-pig ventricular muscles publication-title: J. Physiol. doi: 10.1113/jphysiol.1986.sp016224 – volume: 144 start-page: 55 year: 2018 ident: 10.1016/j.toxicon.2018.12.007_bib78 article-title: Does the phycotoxin Okadaic acid cause oxidative stress damages and histological alterations to seabream (Sparus aurata)? publication-title: Toxicon doi: 10.1016/j.toxicon.2018.02.001 – volume: 101 start-page: 121 year: 2017 ident: 10.1016/j.toxicon.2018.12.007_bib45 article-title: In vitro bioaccessibility of the marine biotoxins okadaic acid, dinophysistoxin-2 and their 7-O-acyl fatty acid ester derivatives in raw and steamed shellfish publication-title: Food Chem. Toxicol. doi: 10.1016/j.fct.2017.01.008 – volume: 102 start-page: 32 year: 2015 ident: 10.1016/j.toxicon.2018.12.007_bib88 article-title: Occurrence and profiles of lipophilic toxins in shellfish harvested from Argentina publication-title: Toxicon doi: 10.1016/j.toxicon.2015.05.010 – volume: 47 start-page: 174 year: 2006 ident: 10.1016/j.toxicon.2018.12.007_bib13 article-title: Investigation of the toxin profile of Greek mussels Mytilus galloprovincialis by liquid chromatography-mass spectrometry publication-title: Toxicon doi: 10.1016/j.toxicon.2005.10.012 – volume: 55 start-page: 724 year: 2010 ident: 10.1016/j.toxicon.2018.12.007_bib44 article-title: Determination of okadaic acid, dinophysistoxin-1 and related esters in Greek mussels using HPLC with fluorometric detection, LC-MS/MS and mouse bioassay publication-title: Toxicon doi: 10.1016/j.toxicon.2009.10.026 – volume: 126 start-page: 23 year: 2017 ident: 10.1016/j.toxicon.2018.12.007_bib15 article-title: Sublethal doses of dinophysistoxin-1 and okadaic acid stimulate secretion of inflammatory factors on innate immune cells: negative health consequences publication-title: Toxicon doi: 10.1016/j.toxicon.2016.12.005 – volume: 11 start-page: 1763 year: 2013 ident: 10.1016/j.toxicon.2018.12.007_bib58 article-title: Identification of dynamic changes in proteins associated with the cellular cytoskeleton after exposure to okadaic acid publication-title: Mar. Drugs doi: 10.3390/md11061763 – volume: 24 start-page: 437 year: 2009 ident: 10.1016/j.toxicon.2018.12.007_bib103 article-title: Morphological and biochemical changes associated with apoptosis induced by okadaic acid in human amniotic FL cells publication-title: Environ. Toxicol. doi: 10.1002/tox.20446 – volume: 78 start-page: 814 year: 2015 ident: 10.1016/j.toxicon.2018.12.007_bib65 article-title: In vitro analysis of early genotoxic and cytotoxic effects of okadaic acid in different cell types of the mussel Mytilus galloprovincialis publication-title: J. Toxicol. Environ. Health doi: 10.1080/15287394.2015.1051173 – volume: 81 start-page: 10208 year: 2009 ident: 10.1016/j.toxicon.2018.12.007_bib79 article-title: Development and single-laboratory validation of a pseudofunctional biosensor immunoassay for the detection of the okadaic acid group of toxins publication-title: Anal. Chem. doi: 10.1021/ac902084a – volume: 366 start-page: 894 year: 2006 ident: 10.1016/j.toxicon.2018.12.007_bib51 article-title: Detection of the marine toxin okadaic acid in mussels during a diarrhetic shellfish poisoning (DSP) episode in Thermaikos Gulf, Greece, using biological, chemical and immunological methods publication-title: Sci. Total Environ. doi: 10.1016/j.scitotenv.2005.03.002 – volume: 5 start-page: 464 year: 1992 ident: 10.1016/j.toxicon.2018.12.007_bib74 article-title: Three new microcystins, cyclic heptapeptide hepatotoxins, from Nostoc sp. strain 152 publication-title: Chem. Res. Toxicol. doi: 10.1021/tx00028a003 – volume: 407 start-page: 1303 year: 2015 ident: 10.1016/j.toxicon.2018.12.007_bib101 article-title: Simultaneous detection of microcysin-LR and okadaic acid using a dual fluorescence resonance energy transfer aptasensor publication-title: Anal. Bioanal. Chem. doi: 10.1007/s00216-014-8378-3 – volume: 60 start-page: 49 year: 2016 ident: 10.1016/j.toxicon.2018.12.007_bib49 article-title: Use of biosensors for the detection of marine toxins publication-title: Essays Biochem. doi: 10.1042/EBC20150006 – start-page: 1155 year: 2013 ident: 10.1016/j.toxicon.2018.12.007_bib77 article-title: Chapter 38 - phycotoxins – volume: 41 start-page: 1138 year: 2018 ident: 10.1016/j.toxicon.2018.12.007_bib72 article-title: Quercetin inhibits okadaic acid-induced tau protein hyperphosphorylation through the Ca2+calpainp25CDK5 pathway in HT22 cells publication-title: Int. J. Mol. Med. – volume: 103 start-page: 2467 year: 1981 ident: 10.1016/j.toxicon.2018.12.007_bib71 article-title: Acanthifolicin, a new episufide-containing polyether carboxylic acid from extracts of the marine sponge Pandaros acanthifolium publication-title: J. Am. Chem. Soc. doi: 10.1021/ja00399a081 – volume: 33 start-page: 1711 year: 2016 ident: 10.1016/j.toxicon.2018.12.007_bib23 article-title: Determination of the toxic variability of lipophilic biotoxins in marine bivalve and gastropod tissues treated with an industrial canning process publication-title: Food Addit. Contam. Part A Chem. Anal. Control Expo. Risk Assess. doi: 10.1080/19440049.2016.1239032 – volume: 24 start-page: 104 year: 1987 ident: 10.1016/j.toxicon.2018.12.007_bib73 article-title: Unique vasocontraction of okadaic acid isolated from black sponge, independent of extracellular Ca2+ publication-title: Blood Vessel. – volume: 116 start-page: 343 year: 2013 ident: 10.1016/j.toxicon.2018.12.007_bib93 article-title: Determination of okadaic acid in shellfish by using a novel chemiluminescent enzyme-linked immunosorbent assay method publication-title: Talanta doi: 10.1016/j.talanta.2013.05.057 – volume: 507 start-page: 81 year: 2001 ident: 10.1016/j.toxicon.2018.12.007_bib96 article-title: Hyperphosphorylation and accumulation of neurofilament proteins in Alzheimer disease brain and in okadaic acid-treated SY5Y cells publication-title: FEBS Lett. doi: 10.1016/S0014-5793(01)02944-1 – volume: 284 start-page: 539 issue: Pt 2 year: 1992 ident: 10.1016/j.toxicon.2018.12.007_bib84 article-title: Inhibitory effect of okadaic acid derivatives on protein phosphatases. A study on structure-affinity relationship publication-title: Biochem. J. doi: 10.1042/bj2840539 – volume: 48 start-page: 309 year: 1996 ident: 10.1016/j.toxicon.2018.12.007_bib46 article-title: Inhibition of protein synthesis in a cell-free system and Vero cells by okadaic acid, a diarrhetic shellfish toxin publication-title: J. Toxicol. Environ. Health doi: 10.1080/009841096161357 – volume: 174 start-page: 1116 year: 2017 ident: 10.1016/j.toxicon.2018.12.007_bib100 article-title: Protein phosphatase 2A regulation of markers of extracellular matrix remodelling in hepatocellular carcinoma cells: functional consequences for tumour invasion publication-title: Br. J. Pharmacol. doi: 10.1111/bph.13759 – volume: 241 start-page: 1825 year: 2016 ident: 10.1016/j.toxicon.2018.12.007_bib107 article-title: Influence of okadaic acid on hyperphosphorylation of tau and nicotinic acetylcholine receptors in primary neurons publication-title: Exp. Biol. Med. doi: 10.1177/1535370216650759 – volume: 83 start-page: 229 year: 2015 ident: 10.1016/j.toxicon.2018.12.007_bib29 article-title: Okadaic acid is taken-up into the cells mediated by human hepatocytes transporter OATP1B3 publication-title: Food Chem. Toxicol. doi: 10.1016/j.fct.2015.06.006 – volume: 11 start-page: 4328 year: 2013 ident: 10.1016/j.toxicon.2018.12.007_bib92 article-title: Okadaic acid: more than a diarrheic toxin publication-title: Mar. Drugs doi: 10.3390/md11114328 – volume: 339 start-page: 154 year: 2017 ident: 10.1016/j.toxicon.2018.12.007_bib98 article-title: Detection of okadaic acid (OA) using ELISA and colloidal gold immunoassay based on monoclonal antibody publication-title: J. Hazard Mater. doi: 10.1016/j.jhazmat.2017.06.030 – volume: 7 start-page: 387 year: 1999 ident: 10.1016/j.toxicon.2018.12.007_bib16 article-title: Methodological improvement of the protein phosphatase inhibition assay for the detection of okadaic acid in mussels publication-title: Nat. Toxins doi: 10.1002/1522-7189(199911/12)7:6<387::AID-NT87>3.0.CO;2-N – volume: 27 start-page: 571 year: 2011 ident: 10.1016/j.toxicon.2018.12.007_bib82 article-title: LC-MS/MS analysis of diarrhetic shellfish poisoning (DSP) toxins, okadaic acid and dinophysistoxin analogues, and other lipophilic toxins publication-title: Anal. Sci. doi: 10.2116/analsci.27.571 – volume: 44 start-page: 1249 year: 1978 ident: 10.1016/j.toxicon.2018.12.007_bib105 article-title: Occurrence of a new type of shellfish poisoning in the Tohoku district publication-title: Bull. Jpn. Soc. Sci. Fish. doi: 10.2331/suisan.44.1249 – volume: 42 start-page: 161 year: 2017 ident: 10.1016/j.toxicon.2018.12.007_bib36 article-title: Metabolism of okadaic acid by NADPH-dependent enzymes present in human or rat liver S9 fractions results in different toxic effects publication-title: Toxicol. Vitro doi: 10.1016/j.tiv.2017.04.009 – volume: 89 start-page: 54 year: 2016 ident: 10.1016/j.toxicon.2018.12.007_bib6 article-title: In vitro bioaccessibility of the marine biotoxin okadaic acid in shellfish publication-title: Food Chem. Toxicol. doi: 10.1016/j.fct.2016.01.008 – volume: 37 start-page: 163 year: 2013 ident: 10.1016/j.toxicon.2018.12.007_bib32 article-title: Okadaic acid induced neurotoxicity: an emerging tool to study Alzheimer's disease pathology publication-title: Neurotoxicology doi: 10.1016/j.neuro.2013.05.002 – volume: 111 start-page: 560 year: 2014 ident: 10.1016/j.toxicon.2018.12.007_bib43 article-title: Detection, occurrence and monthly variations of typical lipophilic marine toxins associated with diarrhetic shellfish poisoning in the coastal seawater of Qingdao City, China publication-title: Chemosphere doi: 10.1016/j.chemosphere.2014.05.006 – volume: 21 start-page: 55 year: 2006 ident: 10.1016/j.toxicon.2018.12.007_bib40 article-title: Genotoxicity of the marine toxin okadaic acid, in human Caco-2 cells and in mice gut cells publication-title: Environ. Toxicol. doi: 10.1002/tox.20154 – volume: 110 start-page: 101 year: 2017 ident: 10.1016/j.toxicon.2018.12.007_bib102 article-title: SLM, a novel carbazole-based fluorophore attenuates okadaic acid-induced tau hyperphosphorylation via down-regulating GSK-3 beta activity in SH-SY5Y cells publication-title: Eur. J. Pharm. Sci. doi: 10.1016/j.ejps.2017.03.037 – volume: 16 start-page: 145 year: 2011 ident: 10.1016/j.toxicon.2018.12.007_bib68 article-title: Modulation of ROS/MAPK signaling pathways by okadaic acid leads to cell death via, mitochondrial mediated caspase-dependent mechanism publication-title: Apoptosis doi: 10.1007/s10495-010-0554-0 – volume: 243 start-page: 1167 year: 1987 ident: 10.1016/j.toxicon.2018.12.007_bib59 article-title: Calcium-independent phosphorylation of smooth muscle myosin light chain by okadaic acid isolated from black sponge (Halichondria okadai) publication-title: J. Pharmacol. Exp. Therapeut. – volume: 15 start-page: 277 year: 2001 ident: 10.1016/j.toxicon.2018.12.007_bib41 article-title: Study of cytoskeletal changes induced by okadaic acid in BE(2)-M17 cells by means of a quantitative fluorimetric microplate assay publication-title: Toxicol. Vitro doi: 10.1016/S0887-2333(01)00021-2 – volume: 335 start-page: 356 year: 1987 ident: 10.1016/j.toxicon.2018.12.007_bib60 article-title: Direct activation by okadaic acid of the contractile elements in the smooth muscle of Guinea-pig taenia coli publication-title: Naunyn-Schmiedeberg’s Arch. Pharmacol. doi: 10.1007/BF00172811 – volume: 133 start-page: 74 year: 2017 ident: 10.1016/j.toxicon.2018.12.007_bib31 article-title: Exposure of okadaic acid alters the angiogenesis in developing chick embryos publication-title: Toxicon doi: 10.1016/j.toxicon.2017.05.003 – volume: 30 start-page: 699 year: 2010 ident: 10.1016/j.toxicon.2018.12.007_bib69 article-title: Naturally contaminated shellfish samples: quantification of diarrhetic shellfish poisoning toxins in unhydrolysed and hydrolysed extracts and cytotoxicity assessment publication-title: J. Appl. Toxicol. doi: 10.1002/jat.1546 – volume: 45 start-page: 633 year: 2005 ident: 10.1016/j.toxicon.2018.12.007_bib54 article-title: Morphology, toxin composition and pigment content of Prorocentrum lima strains isolated from a coastal lagoon in southern UK publication-title: Toxicon doi: 10.1016/j.toxicon.2004.12.023 – volume: 483 start-page: 585 year: 2017 ident: 10.1016/j.toxicon.2018.12.007_bib80 article-title: Passive immunization targeting the N-terminal region of phosphorylated tau (residues 68-71) improves spatial memory in okadaic acid induced tauopathy model rats publication-title: Biochem. Biophys. Res. Commun. doi: 10.1016/j.bbrc.2016.12.101 – volume: 96 start-page: 77 year: 2013 ident: 10.1016/j.toxicon.2018.12.007_bib75 article-title: Quantitative determination of the okadaic acid toxins group by a colorimetric phosphatase inhibition assay: interlaboratory study publication-title: J. AOAC Int. doi: 10.5740/jaoacint.11-465 – volume: 19 start-page: 33 year: 2017 ident: 10.1016/j.toxicon.2018.12.007_bib61 article-title: Label-free okadaic acid detection using growth of gold nanoparticles in sensor gaps as a conductive tag publication-title: Biomed. Microdevices doi: 10.1007/s10544-017-0162-7 – volume: 38 start-page: 1043 year: 2000 ident: 10.1016/j.toxicon.2018.12.007_bib85 article-title: Okadaic acid production from the marine benthic dinoflagellate Prorocentrum arenarium Faust (Dinophyceae) isolated from Europa Island coral reef ecosystem (SW Indian Ocean) publication-title: Toxicon doi: 10.1016/S0041-0101(99)00216-0 – volume: 90 start-page: 416 year: 2012 ident: 10.1016/j.toxicon.2018.12.007_bib70 article-title: Comparative study of toxicological and cell cycle effects of okadaic acid and dinophysistoxin-2 in primary rat hepatocytes publication-title: Life Sci. doi: 10.1016/j.lfs.2011.12.021 – volume: 25 start-page: 61 year: 2007 ident: 10.1016/j.toxicon.2018.12.007_bib24 article-title: N-(p-amylcinnamoyl)anthranilic acid (ACA): a phospholipase A(2) inhibitor and TRP channel blocker publication-title: Cardiovasc. Drug Rev. doi: 10.1111/j.1527-3466.2007.00005.x – volume: 11 start-page: 1171 year: 1990 ident: 10.1016/j.toxicon.2018.12.007_bib53 article-title: Permeability of a non-TPA-type tumor promoter, okadaic acid, through lipid bilayer membrane publication-title: Carcinogenesis doi: 10.1093/carcin/11.7.1171 – volume: 689 start-page: 74 year: 2010 ident: 10.1016/j.toxicon.2018.12.007_bib91 article-title: Assessment of okadaic acid effects on cytotoxicity, DNA damage and DNA repair in human cells publication-title: Mutat. Res. doi: 10.1016/j.mrfmmm.2010.05.004 – volume: 77 start-page: 573 year: 2016 ident: 10.1016/j.toxicon.2018.12.007_bib106 article-title: A novel sensitive cell-based Love Wave biosensor for marine toxin detection publication-title: Biosens. Bioelectron. doi: 10.1016/j.bios.2015.07.062 – volume: 33 start-page: 136 year: 2016 ident: 10.1016/j.toxicon.2018.12.007_bib18 article-title: Modulation of CYP3A4 activity alters the cytotoxicity of lipophilic phycotoxins in human hepatic HepaRG cells publication-title: Toxicol. Vitro doi: 10.1016/j.tiv.2016.02.021 – volume: 34 start-page: 965 year: 1996 ident: 10.1016/j.toxicon.2018.12.007_bib87 article-title: Suitability of the MTT-based cytotoxicity assay to detect okadaic acid contamination of mussels publication-title: Toxicon doi: 10.1016/0041-0101(96)00073-6 – volume: 10 year: 2018 ident: 10.1016/j.toxicon.2018.12.007_bib63 article-title: Overview of the cytoskeleton from an evolutionary perspective publication-title: Cold Spring Harb. Perspect. Biol. doi: 10.1101/cshperspect.a030288 – volume: 21 start-page: 550 year: 2017 ident: 10.1016/j.toxicon.2018.12.007_bib56 article-title: Toward neuroproteomics in biological psychiatry: a systems approach unravels okadaic acid-induced alterations in the neuronal phosphoproteome publication-title: OMICS doi: 10.1089/omi.2017.0108 – volume: 176 start-page: 10 year: 2017 ident: 10.1016/j.toxicon.2018.12.007_bib8 article-title: ACA, an inhibitor phospholipases A2 and transient receptor potential melastatin-2 channels, attenuates okadaic acid induced neurodegeneration in rats publication-title: Life Sci. doi: 10.1016/j.lfs.2017.03.022 – volume: 25 start-page: 1796 year: 2011 ident: 10.1016/j.toxicon.2018.12.007_bib9 article-title: Okadaic acid induces apoptosis through the PKR, NF-kappaB and caspase pathway in human osteoblastic osteosarcoma MG63 cells publication-title: Toxicol. Vitro doi: 10.1016/j.tiv.2011.09.014 – volume: 39 start-page: 1021 year: 2001 ident: 10.1016/j.toxicon.2018.12.007_bib20 article-title: A cytotoxicity assay for the detection and differentiation of two families of shellfish toxins publication-title: Toxicon doi: 10.1016/S0041-0101(00)00241-5 – volume: 50 start-page: 852 year: 2014 ident: 10.1016/j.toxicon.2018.12.007_bib33 article-title: Molecular and cellular mechanism of okadaic acid (OKA)-induced neurotoxicity: a novel tool for Alzheimer's disease therapeutic application publication-title: Mol. Neurobiol. doi: 10.1007/s12035-014-8699-4 – volume: 133 start-page: 6 year: 2018 ident: 10.1016/j.toxicon.2018.12.007_bib42 article-title: Self-assembled monolayer-based immunoassays for okadaic acid detection in seawater as monitoring tools publication-title: Mar. Environ. Res. doi: 10.1016/j.marenvres.2017.11.004 – volume: 88 start-page: 77 year: 2014 ident: 10.1016/j.toxicon.2018.12.007_bib14 article-title: Okadaic acid: a rapid inducer of lamellar bodies in small intestinal enterocytes publication-title: Toxicon doi: 10.1016/j.toxicon.2014.06.011 – volume: 5 start-page: 9 year: 2012 ident: 10.1016/j.toxicon.2018.12.007_bib81 article-title: Differences in susceptibility to okadaic acid, a diarrhetic shellfish poisoning toxin, between male and female mice publication-title: Toxins doi: 10.3390/toxins5010009 – volume: vol. 103 start-page: 2469 year: 1981 ident: 10.1016/j.toxicon.2018.12.007_bib83 – volume: 62 start-page: 3044 year: 2002 ident: 10.1016/j.toxicon.2018.12.007_bib86 article-title: A dominant negative c-jun specifically blocks okadaic acid-induced skin tumor promotion publication-title: Cancer Res. – volume: 284 start-page: 96 year: 2018 ident: 10.1016/j.toxicon.2018.12.007_bib10 article-title: Maduramicin-activated protein phosphatase 2A results in extracellular signal-regulated kinase 1/2 inhibition, leading to cytotoxicity in myocardial H9c2 cells publication-title: Toxicol. Lett. doi: 10.1016/j.toxlet.2017.12.003 – volume: 100 start-page: 311 year: 2011 ident: 10.1016/j.toxicon.2018.12.007_bib34 article-title: Mitochondrial dysfunction: a crucial event in okadaic acid (ICV) induced memory impairment and apoptotic cell death in rat brain publication-title: Pharmacol. Biochem. Behav. doi: 10.1016/j.pbb.2011.08.019 – volume: 28 start-page: 700 year: 2013 ident: 10.1016/j.toxicon.2018.12.007_bib62 article-title: Attenuation of low dose methylmercury and glutamate induced-cytotoxicity and tau phosphorylation by an N-methyl-D-aspartate antagonist in human neuroblastoma (SHSY5Y) cells publication-title: Environ. Toxicol. doi: 10.1002/tox.20765 – volume: 190 start-page: 166 year: 2018 ident: 10.1016/j.toxicon.2018.12.007_bib4 article-title: Combined effect of temperature and nutritional regime on the elimination of the lipophilic toxin okadaic acid in the naturally contaminated wedge shell Donax trunculus publication-title: Chemosphere doi: 10.1016/j.chemosphere.2017.09.100 – volume: 159 start-page: 337 year: 2010 ident: 10.1016/j.toxicon.2018.12.007_bib17 article-title: The methyl ester of okadaic acid is more potent than okadaic acid in disrupting the actin cytoskeleton and metabolism of primary cultured hepatocytes publication-title: Br. J. Pharmacol. doi: 10.1111/j.1476-5381.2009.00512.x – volume: 179 start-page: 243 year: 2015 ident: 10.1016/j.toxicon.2018.12.007_bib99 article-title: Cultivation of the benthic microalga Prorocentrum lima for the production of diarrhetic shellfish poisoning toxins in a vertical flat photobioreactor publication-title: Bioresour. Technol. doi: 10.1016/j.biortech.2014.12.019 – volume: 9 start-page: 9414 year: 2009 ident: 10.1016/j.toxicon.2018.12.007_bib95 article-title: Use of biosensors as alternatives to current regulatory methods for marine biotoxins publication-title: Sensors doi: 10.3390/s91109414 |
| SSID | ssj0003896 |
| Score | 2.5398476 |
| SecondaryResourceType | review_article |
| Snippet | Okadaic acid (OA), a potent polyether marine toxin, accumulates in the digestive glands of marine mollusks and therefore can severely threaten the health of... |
| SourceID | proquest pubmed crossref elsevier |
| SourceType | Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 1 |
| SubjectTerms | death Detection Detoxification Diarrhetic shellfish poisoning hepatocytes human health humans in vitro studies ingestion molluscs Okadaic acid poisoning Protein phosphatase researchers shellfish toxicity |
| Title | Okadaic acid (OA): Toxicity, detection and detoxification |
| URI | https://dx.doi.org/10.1016/j.toxicon.2018.12.007 https://www.ncbi.nlm.nih.gov/pubmed/30639658 https://www.proquest.com/docview/2179339320 https://www.proquest.com/docview/2220844228 |
| Volume | 160 |
| WOSCitedRecordID | wos000462420300001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| journalDatabaseRights | – providerCode: PRVESC databaseName: Elsevier SD Freedom Collection Journals 2021 customDbUrl: eissn: 1879-3150 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0003896 issn: 0041-0101 databaseCode: AIEXJ dateStart: 19950101 isFulltext: true titleUrlDefault: https://www.sciencedirect.com providerName: Elsevier |
| link | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1bb9owFLZWuoe9TFu7C7tUmTShTcMscULs7A1NoK2qoA9UyptlHKdK1wVWwgT_fseXBCq1a_ewlwiCHQLny7l89jkHofdhGCeg83wM9jTDUTwLcKJiiRU4C36uQw7hm2YTdDxmaZqcunZHS9NOgJYlW6-TxX8VNZwDYevU2X8Qd3NROAGvQehwBLHD8V6Cn_wQmdBVWGVhCILJAKJ9w6LP14V0TQAyVSnXJLzM9Dv4LHf03a6_auYYgDCbWrjDHIxWLqg_x5e1AbQUtKFf00LM8WbVbNEp3GicbQGZmkscu-rfjnzQ-U4htumXtUKNNBvh-Ihaocb-p0UvwHRHMQY7FpbeqLoti3DRq-wP07vumGFqbVfc66WyxxM-Ojs54dNhOu0sfmHdRUyvtruWKnton9B-wlpof_B9mB43thncs9juObC3vc3p-nzjN9_mrdwWjRivZPoEPXbhhDewMHiKHqjyAB0OSlHNf268jmc2-JqVkwPUObVlyjddb7rNult2zbCmgPnmECUOQp6GkPdhMvj4xavB0_Ua6HgAHe86dJ6hs9Fw-vUbdi02sIxIVGGZzaIky8MgkhkRcZiJkEgqqaIQ-Ge-kDPClJKBCijNaRyxfs4EjcGFETJU4Ao-R61yXqqXyJMCHm8V576MaaSynPUTIkkEBgRMmKT9Norqv5JLV39et0G55PVGwwvuJMC1BHhAOEigjXrNtIUtwHLXBFbLiTsv0nqHHJB219R3tVw5aFm9dCZKNV8tOdF2LIRYx__LGEJ8FumSem30woKiueNQRwLg7L-6x-zX6NH2UXuDWtXVSr1FD-XvqlheHaE9mrIjh-s_yDeusQ |
| linkProvider | Elsevier |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Okadaic+acid+%28OA%29%3A+Toxicity%2C+detection+and+detoxification&rft.jtitle=Toxicon+%28Oxford%29&rft.au=Fu%2C+Ling-ling&rft.au=Zhao%2C+Xiao-yu&rft.au=Ji%2C+Lin-dan&rft.au=Xu%2C+Jin&rft.date=2019-03-15&rft.issn=0041-0101&rft.volume=160+p.1-7&rft.spage=1&rft.epage=7&rft_id=info:doi/10.1016%2Fj.toxicon.2018.12.007&rft.externalDBID=NO_FULL_TEXT |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0041-0101&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0041-0101&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0041-0101&client=summon |