Fertility and Pregnancy Outcomes in Women with Polycystic Ovary Syndrome Following Bariatric Surgery

Restoration of ovulation is quite common in women with polycystic ovary syndrome (PCOS) after surgically induced weight loss. Whether or not this results in an improvement of PCOS-associated infertility is uncertain. To study fertility and gestational outcomes in women with PCOS after bariatric surg...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:The journal of clinical endocrinology and metabolism Ročník 105; číslo 9; s. e3384 - e3391
Hlavní autoři: Benito, Estela, Gómez-Martin, Jesús M, Vega-Piñero, Belén, Priego, Pablo, Galindo, Julio, Escobar-Morreale, Héctor F, Botella-Carretero, José I
Médium: Journal Article
Jazyk:angličtina
Vydáno: United States Oxford University Press 01.09.2020
Témata:
Adult
Bariatric Surgery - statistics & numerical data
Birth Rate
Birth weight
Case-Control Studies
Cohort Studies
Female
Fertility
Fertility - physiology
Gastrointestinal surgery
Humans
Hydroxyprogesterone
Infant, Newborn
Infants (Newborn)
Infertility
Infertility, Female - epidemiology
Infertility, Female - etiology
Infertility, Female - surgery
Live Birth - epidemiology
Low birth weight
Menopause
Neonates
Obesity
Obesity - complications
Obesity - epidemiology
Obesity - surgery
Ovaries
Ovulation
Polycystic ovary syndrome
Polycystic Ovary Syndrome - complications
Polycystic Ovary Syndrome - epidemiology
Polycystic Ovary Syndrome - surgery
Pregnancy
Pregnancy Outcome - epidemiology
Pregnant women
Stein-Leventhal syndrome
Surgery
Spain
obesity surgery
live birth
conception
fertility
pregnancy
ISSN:0021-972X, 1945-7197, 1945-7197
On-line přístup:Získat plný text
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!
Popis
Shrnutí:Restoration of ovulation is quite common in women with polycystic ovary syndrome (PCOS) after surgically induced weight loss. Whether or not this results in an improvement of PCOS-associated infertility is uncertain. To study fertility and gestational outcomes in women with PCOS after bariatric surgery. Unicenter cohort study. Academic hospital. Two hundred and sixteen premenopausal women were screened for PCOS before bariatric surgery. Women were followed-up after the intervention until mid-2019 regardless of having or not PCOS. All participants underwent bariatric surgery from 2005 to 2015. Pregnancy and live birth rates in the PCOS and control groups. In women seeking fertility, pregnancy rates were 95.2% in PCOS and 76.9% in controls (P = 0.096) and live birth rates were 81.0% and 69.2%, respectively (P = 0.403). The time to achieve the first pregnancy after surgery was 34 ± 28 months in women with PCOS and 32 ± 25 months in controls. Albeit the mean birth weight was lower (P = 0.040) in newborns from women with PCOS (2763 ± 618 g) compared with those from controls (3155 ± 586 g), the number of newborns with low birth weight was similar in both groups (3 in the PCOS group and 1 in the controls, P = 0.137). Maternal (17.6% in PCOS and 22.2% in controls, P = 0.843) and neonatal (23.5% in PCOS and 14.8% in controls, P = 0.466) complications were rare, showing no differences between groups. Pregnancy and fertility rates in very obese women with PCOS after bariatric surgery were high, with few maternal and neonatal complications.
Bibliografie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
content type line 23
ISSN:0021-972X
1945-7197
1945-7197
DOI:10.1210/clinem/dgaa439