Endothelial Epas1 Deficiency Is Sufficient To Promote Parietal Epithelial Cell Activation and FSGS in Experimental Hypertension

FSGS, the most common primary glomerular disorder causing ESRD, is a complex disease that is only partially understood. Progressive sclerosis is a hallmark of FSGS, and genetic tracing studies have shown that parietal epithelial cells participate in the formation of sclerotic lesions. The loss of po...

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Veröffentlicht in:	Journal of the American Society of Nephrology Jg. 28; H. 12; S. 3563
Hauptverfasser:	Luque, Yosu, Lenoir, Olivia, Bonnin, Philippe, Hardy, Lise, Chipont, Anna, Placier, Sandrine, Vandermeersch, Sophie, Xu-Dubois, Yi-Chun, Robin, Blaise, Lazareth, Hélène, Souyri, Michèle, Guyonnet, Léa, Baudrie, Véronique, Camerer, Eric, Rondeau, Eric, Mesnard, Laurent, Tharaux, Pierre-Louis
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 01.12.2017
Schlagworte:	Albumins - analysis Angiotensin II - metabolism Animals Basic Helix-Loop-Helix Transcription Factors - deficiency Basic Helix-Loop-Helix Transcription Factors - genetics Basic Helix-Loop-Helix Transcription Factors - metabolism Blood Pressure Cell Differentiation Crosses, Genetic Disease Progression Epithelial Cells - cytology Epithelial Cells - metabolism Gene Deletion Gene Expression Regulation Glomerulosclerosis, Focal Segmental - metabolism Hypertension - metabolism Kidney Glomerulus - metabolism Male Mice Mice, Inbred C57BL Mice, Knockout Mice, Transgenic Podocytes - metabolism Telemetry glomerular epithelial cells endothelial cells glomerular endothelial cells Pathophysiology of Renal Disease and Progression focal segmental glomerulosclerosis hypertension
ISSN:	1533-3450, 1533-3450
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