Axonal loss and myelin in early ON loss in postacute optic neuritis

Objective To investigate the relation between retinal nerve fiber layer (RNFL) thickness and latency and amplitude of multifocal visual‐evoked potentials (mfVEPs) in the postacute stage of optic neuritis in patients with early or possible multiple sclerosis. Method Thirty‐two patients with clinical...

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Vydané v:	Annals of neurology Ročník 64; číslo 3; s. 325 - 331
Hlavní autori:	Klistorner, Alexander, Arvind, Hemamalini, Nguyen, Than, Garrick, Raymond, Paine, Mark, Graham, Stuart, O'Day, Justin, Grigg, John, Billson, Francis, Yiannikas, Con
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.09.2008 Willey-Liss
Predmet:	Acute Disease Adult Axons - pathology Biological and medical sciences Cross-Sectional Studies Disease Progression Diseases of visual field, optic nerve, optic chiasma and optic tracts Electrodiagnosis Evoked Potentials, Visual - physiology Female Humans Magnetic Resonance Imaging Male Medical sciences Middle Aged Myelin Sheath - pathology Nerve Degeneration - etiology Nerve Degeneration - pathology Nerve Degeneration - physiopathology Neural Conduction - physiology Neurology Ophthalmology Optic Nerve - pathology Optic Nerve - physiopathology Optic Neuritis - pathology Optic Neuritis - physiopathology Predictive Value of Tests Prospective Studies Reaction Time - physiology Retina - pathology Retina - physiopathology Retinal Ganglion Cells - pathology Time Factors Tomography, Optical Coherence Eye disease Nervous system diseases Cranial nerve disease Optic nerve Visual pathway Optic nevritis Myelin Optic neuritis
ISSN:	0364-5134, 1531-8249, 1531-8249
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Shrnutí:	Objective To investigate the relation between retinal nerve fiber layer (RNFL) thickness and latency and amplitude of multifocal visual‐evoked potentials (mfVEPs) in the postacute stage of optic neuritis in patients with early or possible multiple sclerosis. Method Thirty‐two patients with clinical diagnosis of unilateral optic neuritis and magnetic resonance imaging lesions typical of demyelination and 25 control subjects underwent mfVEP and optical coherence tomography imaging. Results Although there was significant reduction of RNFL thickness in the affected eyes (18.7%), a considerably larger decrease was observed for the amplitude of the mfVEPs (39.8%). Latency of the mfVEPs was also significantly delayed in optic neuritis eyes. In fellow eyes, the amplitude of mfVEPs was significantly reduced and the latency prolonged, but RNFL thickness remained unaltered. RNFL thickness correlated highly with the mfVEP amplitude (r = 0.90). There was also strong correlation between optical coherence tomography measure of axonal loss and mfVEP latency (r = −0.66). Interpretation Although our findings demonstrate strong associations between structural and functional measures of optic nerve integrity, the functional loss was more marked. This fact, together with amplitude and latency changes of the mfVEPs observed in clinically normal fellow eyes, may indicate greater sensitivity of mfVEPs in detecting optic nerve abnormality or the presence of widespread inflammation in the central nervous system, or both. The significant correlation of the mfVEP latency with RNFL thickness suggests a role for demyelination in promoting axonal loss. Ann Neurol 2008
Bibliografia:	ArticleID:ANA21474 istex:5AD7237421D77272923DC8D01AF0246918C2DE2E Sydney Medical Foundation ark:/67375/WNG-73T5SSVD-S ORIA ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0364-5134 1531-8249 1531-8249
DOI:	10.1002/ana.21474