Cholesterol affects retinal nerve fiber layer thickness in patients with multiple sclerosis with optic neuritis

Background and purpose To evaluate the associations between retinal nerve fiber layer (RNFL) thickness and lipid profiles in multiple sclerosis (MS). Methods This study enrolled 136 patients with MS (n = 272 eyes; 108 females, 28 males, mean age: 46.7 ± 8.9 years); 45% had a history of optic neuriti...

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Published in:European journal of neurology Vol. 20; no. 9; pp. 1264 - 1271
Main Authors: Kardys, A., Weinstock-Guttman, B., Dillon, M., Masud, M. W., Weinstock, N., Mahfooz, N., Lang, J. K., Weinstock, A., Lincoff, N., Zivadinov, R., Ramanathan, M.
Format: Journal Article
Language:English
Published: England Blackwell Publishing Ltd 01.09.2013
John Wiley & Sons, Inc
Subjects:
Cholesterol
Cholesterol - blood
Confidence intervals
environment factors
Evoked Potentials, Visual
Female
Humans
Lipids
Low density lipoprotein
Male
Middle Aged
Multiple sclerosis
Multiple Sclerosis - blood
Multiple Sclerosis - pathology
optic neuritis
Optic Neuritis - blood
Optic Neuritis - pathology
Retinal Neurons - pathology
Tomography, Optical Coherence
vision
Visual Acuity
vision
cholesterol
lipids
environment factors
multiple sclerosis
optic neuritis
ISSN:1351-5101, 1468-1331, 1468-1331
Online Access:Get full text
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Summary:Background and purpose To evaluate the associations between retinal nerve fiber layer (RNFL) thickness and lipid profiles in multiple sclerosis (MS). Methods This study enrolled 136 patients with MS (n = 272 eyes; 108 females, 28 males, mean age: 46.7 ± 8.9 years); 45% had a history of optic neuritis (ON). Subjects received optical coherence tomography (OCT) testing to assess RNFL thickness and visual acuity testing with Snellen charts. A subset of 88 patients received pattern reversal visual‐evoked potential (PRVEP) testing. Lipid profiles consisting of serum high‐density lipoprotein (HDL) cholesterol, low‐density lipoprotein (LDL) cholesterol and total cholesterol (TC) levels were obtained within ± 6 months of OCT. Regression analyses were used to assess the associations between RNFL thickness and lipid profile variables. Results Low RNFL thickness (P = 0.008) and higher PRVEP latency (P = 0.017) were associated with high LDL cholesterol > 100 mg/dl status. Low RNFL thickness (P = 0.008) and higher PRVEP latency (P = 0.043) were associated with high HDL cholesterol levels. Low RNFL thickness was also associated with HDL cholesterol > 60 mg/dl status (P = 0.001) and with TC > 200 mg/dl status (P = 0.015). The probability of average RNFL thickness in the lowest tertile (≤ 33rd percentile) was associated with interactions between TC > 200 mg/dl status (P = 0.001, odds ratio = 7.5, 95% confidence interval = 2.7–21) with affected/unaffected by ON status. Conclusions High cholesterol adversely affects RNFL thickness in patients with MS with ON.
Bibliography:National Multiple Sclerosis Society - No. RG3743
ArticleID:ENE12162
ark:/67375/WNG-8QDNGZP2-T
Pediatric MS Center of Excellence Center
Department of Defense Multiple Sclerosis Program - No. MS090122
istex:F1CACE5CEFB764BEE840571D3135D661B690B56B
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ISSN:1351-5101
1468-1331
1468-1331
DOI:10.1111/ene.12162