Cerebrovascular and cardiovascular diseases caused by drugs of abuse

Drugs such as stimulants, sedatives, sleeping pills, and narcotics are associated with drug abuse and are therefore regulated by law. Physical dependence on these drugs is sometimes difficult to control despite an awareness of the problems they cause in daily life and the harm they can cause to the...

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Veröffentlicht in:Hypertension research Jg. 43; H. 5; S. 363 - 371
Hauptverfasser: Akasaki, Yuichi, Ohishi, Mitsuru
Format: Journal Article
Sprache:Englisch
Veröffentlicht: England Nature Publishing Group 01.05.2020
Schlagworte:
Aortic dissection
Blood pressure
Cardiac arrhythmia
Cardiovascular disease
Drug abuse
Drug addiction
Hypertension
Side effects
Stroke
Drug addiction
Stroke
Blood pressure
ISSN:0916-9636, 1348-4214, 1348-4214
Online-Zugang:Volltext
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Zusammenfassung:Drugs such as stimulants, sedatives, sleeping pills, and narcotics are associated with drug abuse and are therefore regulated by law. Physical dependence on these drugs is sometimes difficult to control despite an awareness of the problems they cause in daily life and the harm they can cause to the body. Drug dependence is a social problem worldwide, and the physical implications are serious. Many of these drugs cause cerebrovascular and cardiovascular diseases, which often require emergency medical treatment. Differential diagnosis is essential because of the likelihood of life-threatening events, especially among young people who exhibit cerebrovascular and cardiovascular diseases without any of the typical risk factors. Drugs of abuse, especially stimulants, induce a hyperadrenergic state that evokes vasoconstriction and tachycardia, as well as subsequent ischemic and hemorrhagic stroke, acute coronary syndrome, arrhythmias, and aortic dissection. Chronic drug abuse can also cause cardiac hypertrophy and left ventricular dysfunction. As a treatment for these conditions, sedative drugs can be effective but the use of vasodilators may also be required. There are concerns that the use of both alpha- and beta-adrenergic receptor blockers may cause tachycardia and increased blood pressure. Therefore, careful differential diagnosis and selection of therapeutic agents is required.
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ISSN:0916-9636
1348-4214
1348-4214
DOI:10.1038/s41440-019-0367-7