Ephedra alata Seeds Confer Kidney Protection against Early Life Exposure to Acephate by Regulating Oxidative Insult and Activating Autophagy

The aim of the current work was to examine for the first time the nephropreventive capacity of Ephedra alata seed extract (E) against maternal exposure to acephate in rat offspring. The in vivo results revealed that E. alata supplementation for 28 days (40 mg/kg b.w.) significantly attenuated the ne...

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Bibliographic Details
Published in:	Life (Basel, Switzerland) Vol. 13; no. 12; p. 2254
Main Authors:	Mufti, Afoua, Feriani, Anouar, Contreras, María del Mar, Nehdi, Saber, Hfaeidh, Najla, Tlili, Nizar, Harrath, Abdel Halim
Format:	Journal Article
Language:	English
Published:	Switzerland MDPI AG 25.11.2023
Subjects:	acephate Antioxidants Autophagy Bioactive compounds Biomarkers Creatinine DNA fragmentation Drug dosages Ephedra Ephedra alata Exposure Fatty acids Gene expression Genes Immunofluorescence Kidney diseases Kidneys Laboratory animals Lipid peroxidation Lipids Molecular docking Na+/H+-exchanging ATPase Na+/K+-exchanging ATPase nephrotoxicity Offspring Oxidative stress Peroxidation Pesticides Phytochemicals Proteins Risk factors Seeds Sodium Stress analysis Uric acid United States > US Tunisia acephate Ephedra alata autophagy molecular docking nephrotoxicity oxidative stress
ISSN:	2075-1729, 2075-1729
Online Access:	Get full text
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