Recovery of long-term natural protection against reactivation of CMV retinitis in AIDS patients responding to highly active antiretroviral therapy

Objectives: To see whether in severely immunosuppressed AIDS patients (with prior Cytomegalovirus retinal disease) who have significant increases in CD4+ lymphocytes following the initiation of highly active antiretroviral therapy (HAART) anti-Cytomegalovirus (CMV) maintenance therapy can be withdra...

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Vydáno v:	The Journal of infection Ročník 39; číslo 3; s. 193 - 197
Hlavní autoři:	Di Perri, Giovanni, Vento, Sandro, Mazzi, Romualdo, Bonora, Stefano, Bonora, Adriana, Trevenzoli, Marco, Allegranzi, Benedetta, Carretta, Giovanni, Lanzafame, Massimiliano, Pizzighella, Sergio, Concia, Ercole
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	Kidlington Elsevier Ltd 01.11.1999 Elsevier
Témata:	Acquired Immunodeficiency Syndrome - drug therapy Acquired Immunodeficiency Syndrome - immunology Adult AIDS-Related Opportunistic Infections - drug therapy Anti-HIV Agents - therapeutic use Antibiotics. Antiinfectious agents. Antiparasitic agents Antigens, Viral - blood Antiviral agents Antiviral Agents - therapeutic use Biological and medical sciences CD4 antigen CD4 Lymphocyte Count Cytomegalovirus Cytomegalovirus Retinitis - drug therapy Female highly active antiretroviral therapy Human immunodeficiency virus Humans Male Medical sciences Middle Aged Pharmacology. Drug treatments RNA, Viral - blood Human Immunopathology Opportunistic infection Chemoprophylaxis Reactivation Relapse Retinopathy Herpesviridae AIDS Betaherpesvirinae Immune deficiency Human cytomegalovirus Infection Virus Prevention Eye disease Chemotherapy Treatment Treatment withdrawal Maintenance treatment Viral disease Antiviral Complication Retinitis
ISSN:	0163-4453, 1532-2742
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Popis
Shrnutí:	Objectives: To see whether in severely immunosuppressed AIDS patients (with prior Cytomegalovirus retinal disease) who have significant increases in CD4+ lymphocytes following the initiation of highly active antiretroviral therapy (HAART) anti-Cytomegalovirus (CMV) maintenance therapy can be withdrawn with no subsequent progression of CMV retinitis. Methods: Eight patients with AIDS and one or more previous episodes of CMV retinitis interrupted anti-CMV maintenance therapy following the successful beginning of HAART. CD4 cell counts and HIV-RNA were monitored monthly while measurement of CMV antigenemia and ophthalmoscopy were carried every 2 weeks thereafter. Results: The HAART recipients in whom anti-CMV maintenance therapy had been interrupted had measureable increases of CD4+ T lymphocytes, substantial control of both HIV-RNA and CMV viraemia and did not show recurrence of retinitis during a mean follow-up of 98.4 weeks (range 78–120, SD 15.2). Conclusions: Anti-CMV maintenance therapy can be interrupted with no subsequent progression of retinal damage over a long time in patients with AIDS who successfully respond to HAART with a significant increase in CD4 cell count.
Bibliografie:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Article-1 ObjectType-Feature-2
ISSN:	0163-4453 1532-2742
DOI:	10.1016/S0163-4453(99)90048-8