Human oral retention of zinc from mouthwashes containing zinc salts and its relevance to dental plaque control

Subjects using 30 mM zinc phenolsulphonate as a mouthwash retained 12 per cent of the zinc. Salivary zinc concentration was increased by using mouthwashes containing 17-35 mM zinc as the sulphate, phenolsulphonate or citrate. For 17 mM zinc sulphate or phenolsulphonate, the effect lasted 3-4 h. Zinc...

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Bibliographic Details
Published in:Archives of oral biology Vol. 29; no. 2; p. 87
Main Authors: Harrap, G J, Best, J S, Saxton, C A
Format: Journal Article
Language:English
Published: England 1984
Subjects:
Acids - metabolism
Adolescent
Adult
Benzenesulfonates - metabolism
Benzenesulfonates - therapeutic use
Dental Plaque - metabolism
Dental Plaque - prevention & control
Female
Humans
In Vitro Techniques
Male
Mouth Mucosa - metabolism
Mouthwashes
Saliva - metabolism
Time Factors
Tongue - metabolism
Zinc - metabolism
Zinc - therapeutic use
ISSN:0003-9969
Online Access:Get more information
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Summary:Subjects using 30 mM zinc phenolsulphonate as a mouthwash retained 12 per cent of the zinc. Salivary zinc concentration was increased by using mouthwashes containing 17-35 mM zinc as the sulphate, phenolsulphonate or citrate. For 17 mM zinc sulphate or phenolsulphonate, the effect lasted 3-4 h. Zinc retained in the mouth gave visible fluorescence after rinsing with 8-hydroxyquinoline and was particularly evident on the tongue, cheek mucosa and dental plaque. The concentration of zinc in plaque was increased 13-19-fold 1 h after using 31 or 18 mM zinc phenolsulphonate. A 3-fold increase was still present 6 h later for the 31 mM mouthwash. Zinc salts inhibited acid production from [14C]-glucose in vitro by plaque at concentrations which were found in plaque in vivo after using the mouthwashes. The effect of zinc on the metabolic activity of plaque may reduce the growth rate of plaque-bacteria and so decrease plaque growth.
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ISSN:0003-9969
DOI:10.1016/0003-9969(84)90110-9