Salivary detection of H1N1 virus: a clinical feasibility investigation

The fast and efficient transportation among continents will continue to play a role in the spread of airborne pandemics. The objective of this study was to detect H1N1 virus in the saliva of individuals who visited the emergency department and were diagnosed as having H1N1 influenza. Nasopharyngeal...

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Vydané v:Journal of dental research Ročník 90; číslo 9; s. 1136
Hlavní autori: Bilder, L, Machtei, E E, Shenhar, Y, Kra-Oz, Z, Basis, F
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: United States 01.09.2011
Predmet:
Adult
Aged
Aged, 80 and over
DNA, Viral - analysis
Feasibility Studies
Female
Humans
Influenza A Virus, H1N1 Subtype - isolation & purification
Influenza, Human - diagnosis
Influenza, Human - virology
Israel
Male
Middle Aged
Respiratory Mucosa - virology
Reverse Transcriptase Polymerase Chain Reaction
Saliva - virology
Sensitivity and Specificity
Young Adult
Israel
ISSN:1544-0591, 1544-0591
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Popis
Shrnutí:The fast and efficient transportation among continents will continue to play a role in the spread of airborne pandemics. The objective of this study was to detect H1N1 virus in the saliva of individuals who visited the emergency department and were diagnosed as having H1N1 influenza. Nasopharyngeal swabs and saliva samples from those who presented to the emergency department with flu-like symptoms were sent to the laboratory. RNA was extracted from both samples. Real-time RT-PCR tests were performed, and the saliva and nasopharyngeal swab tests were compared. Samples were drawn from 26 individuals. A positive nasopharyngeal swab test and salivary test was found in 14 persons, and negative tests were found in 12 persons. Saliva sampling for H1N1 has excellent predictive value, is highly accurate and reliable, and is more convenient than the nasopharyngeal swab. Clinical trial with the Helsinki Committee at Rambam Health Care Campus, registration number 036309-RMB.
Bibliografia:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
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ISSN:1544-0591
1544-0591
DOI:10.1177/0022034511413283