GABAA receptor modulating steroid antagonists (GAMSA) are functional in vivo

[Display omitted] •The neurosteroid allopregnanolone positively modulates the GABA-A receptor.•Allopregnanolone induces cognitive deficits and anesthesia.•Positive neurosteroid-enhancement of GABA-A receptors can be antagonized by GAMSA.•GAMSA blocks allopregnanolone-induced learning impairment and...

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Bibliographic Details
Published in:	The Journal of steroid biochemistry and molecular biology Vol. 160; no. SI; pp. 98 - 105
Main Authors:	Johansson, Maja, Strömberg, Jessica, Ragagnin, Gianna, Doverskog, Magnus, Bäckström, Torbjörn
Format:	Journal Article
Language:	English
Published:	England Elsevier Ltd 01.06.2016
Subjects:	Allopregnanolone Animals Cognition Desoxycorticosterone - analogs & derivatives Desoxycorticosterone - metabolism Evoked Potentials - drug effects GABA-A Receptor Antagonists - pharmacology GABAA receptor GAMSA Humans Learning - drug effects Memory - drug effects Neurosteroids Pregnanolone - metabolism Receptors, GABA-A - metabolism Saccades - drug effects 17PA AD Neurosteroids SEV THDOC GAMSA EEG LTP s.c i.p Cognition Allopregnanolone i.v TSPO sIPSC GABAA receptor HE UC1011 GABA(A) receptor
ISSN:	0960-0760, 1879-1220, 1879-1220
Online Access:	Get full text
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