Rapid method for the quantification of amoxicillin and its major metabolites in pig tissues by liquid chromatography-tandem mass spectrometry with emphasis on stability issues

A fast method for the quantitative determination of amoxicillin (AMO), amoxicilloic acid (AMA) and amoxicillin diketopiperazine-2′,5′-dione (DIKETO) in pig edible tissues (kidney, liver, fat and muscle) with liquid chromatography-tandem mass spectrometry (LC-ESI-MS/MS) is presented. The method uses...

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Bibliographic Details
Published in:	Journal of chromatography. B, Analytical technologies in the biomedical and life sciences Vol. 861; no. 1; pp. 108 - 116
Main Authors:	Reyns, Tim, Cherlet, Marc, De Baere, Siegrid, De Backer, Patrick, Croubels, Siska
Format:	Journal Article
Language:	English
Published:	Amsterdam Elsevier B.V 2008 Elsevier Science
Subjects:	Amoxicillin Amoxicillin - analysis Amoxicillin - chemistry Amoxicillin - metabolism Amoxicillin diketopiperazine-2',5'-dione Amoxicilloic acid Analysis Analytical, structural and metabolic biochemistry Animals Biological and medical sciences Chromatography, Liquid - methods electrospray ionization-tandem mass spectrometry Fundamental and applied biological sciences. Psychology General pharmacology Liquid chromatography Liquid chromatography/electrospray ionization-tandem mass spectrometry Medical sciences Molecular Structure Pharmacology. Drug treatments Pig tissues Reproducibility of Results Spectrometry, Mass, Electrospray Ionization - methods Stability Swine Tandem Mass Spectrometry - methods Amoxicilloic acid Amoxicillin diketopiperazine-2′,5′-dione Liquid chromatography/electrospray ionization-tandem mass spectrometry Stability Pig tissues Amoxicillin Metabolite Cyclic peptides Electrospray Penicillin derivatives Tissue Rapid technique Pia tissues Stability Ungulata Quantitative analysis Amoxicillin diketopiperazine-2',5'-dione β-Lactams Pig Vertebrata Antibiotic Mammalia Animal Mass spectrometry MS/MS Dipeptides Artiodactyla Antibacterial agent Physicochemical properties
ISSN:	1570-0232, 1873-376X
Online Access:	Get full text
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