Genetic diversity of Plasmodium falciparum parasites from Kenya is not affected by antifolate drug selection

The genotypes of merozoite surface protein-1, merozoite surface protein-2 and glutamine rich protein are frequently used to distinguish recrudescence from reinfection when parasitaemia reappears after antimalarial drug treatment. However, none of the previous reports has clearly assessed the change...

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Bibliographic Details
Published in:	International journal for parasitology Vol. 32; no. 12; pp. 1469 - 1476
Main Authors:	Nzila, A.M, Mberu, E.K, Nduati, E, Ross, A, Watkins, W.M, Sibley, C.H
Format:	Journal Article
Language:	English
Published:	Oxford Elsevier Ltd 01.11.2002 Elsevier Science
Subjects:	Age Distribution Alleles Animals Antibiotics. Antiinfectious agents. Antiparasitic agents Antifolates Antigens, Protozoan - genetics Antimalarials - pharmacology Antimalarials - therapeutic use Antiparasitic agents Biological and medical sciences Body Temperature Child, Preschool Drug Resistance - genetics Fever - complications Fever - parasitology Folic Acid Antagonists - pharmacology Folic Acid Antagonists - therapeutic use Fundamental and applied biological sciences. Psychology Genes, Protozoan - genetics Genetic Variation - drug effects Genetic Variation - genetics Genetics of eukaryotes. Biological and molecular evolution Humans Infant Kenya Malaria - drug therapy Malaria - parasitology Malaria genetic diversity Medical sciences Merozoite Surface Protein 1 - genetics Parasitemia - drug therapy Parasitemia - parasitology Pharmacology. Drug treatments Plasmodium falciparum Plasmodium falciparum - drug effects Plasmodium falciparum - genetics Plasmodium falciparum - growth & development Plasmodium falciparum - isolation & purification Polymorphism, Genetic - drug effects Polymorphism, Genetic - genetics Population genetics, reproduction patterns Protozoa Protozoan Proteins - genetics Kenya Africa Antifolates Plasmodium falciparum Malaria genetic diversity Protozoa Host parasite relation Antimalarial Apicomplexa Protozoal disease Malaria Parasite Artificial selection Population structure Genetic diversity Parasitosis Population genetics Infection Antifolate Antiprotozoal agent Chemotherapy Parasiticid Polymorphism
ISSN:	0020-7519, 1879-0135
Online Access:	Get full text
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