Familial patterns of covariation for cardiovascular risk factors in adults: The Victorian Family Heart Study

The Victorian Family Heart Study was established to address the causes of familial patterns in cardiovascular risk factors. From 1990 to 1996, a representative population sample of 783 adult families (2,959 individuals), each comprising both parents (40-70 years) and at least one natural adult offsp...

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Veröffentlicht in:American journal of epidemiology Jg. 152; H. 8; S. 704
Hauptverfasser: Harrap, S B, Stebbing, M, Hopper, J L, Hoang, H N, Giles, G G
Format: Journal Article
Sprache:Englisch
Veröffentlicht: United States 15.10.2000
Schlagworte:
Adult
Aged
Australia
Blood Pressure
Cardiovascular Diseases - etiology
Cardiovascular Diseases - genetics
Cholesterol - blood
Diseases in Twins
Environmental Exposure
Family Characteristics
Female
Humans
Male
Middle Aged
Models, Statistical
Pedigree
Phenotype
Risk Factors
Australia
ISSN:0002-9262
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Zusammenfassung:The Victorian Family Heart Study was established to address the causes of familial patterns in cardiovascular risk factors. From 1990 to 1996, a representative population sample of 783 adult families (2,959 individuals), each comprising both parents (40-70 years) and at least one natural adult offspring (18-30 years), was recruited in Melbourne, Australia. Included in both generations were 461 monozygotic and dizygotic twins as pairs or singletons. A multivariate normal model was used for pedigree analysis of height, weight, body mass index, diastolic and systolic blood pressure, pulse rate, and total and high density lipoprotein cholesterol. All traits showed evidence for additive genetic variation, explaining from 55% (height) to 26% (pulse) of age- and sex-adjusted variance. An effect persisting into adulthood of shared family environment during cohabitation explained from 39% (body mass index) to 13% (systolic blood pressure) of variance (not nominally significant for diastolic blood pressure). These shared environmental effects were strongest within twin pairs, less so for sibling pairs, and least for parent-offspring pairs (in which an effect was not observed for weight, diastolic and systolic blood pressure, and total cholesterol). On a background of genetic influences, there are periods in early life during which the family environment cements long-term correlations between adult relatives in cardiovascular risk factors.
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ISSN:0002-9262
DOI:10.1093/aje/152.8.704