Efficacy evaluation with stratified randomized controlled study of foam dentifrice containing isodecyl galactosides in older adults

Oral hygiene is mainly maintained by mechanical plaque removal, but this is often inadequate in older adults. Isodecyl galactosides (ID-Gal) inhibits bacterial co-aggregation and could promote the maintenance and improvement of oral hygiene. In this study, the efficacy of ID-Gal-containing foam dent...

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Bibliographic Details
Published in:Journal of oral science Vol. 67; no. 3; p. 134
Main Authors: Iwawaki, Yuki, Goto, Takaharu, Kishimoto, Takahiro, Matsuda, Takashi, Fujimoto, Keiko, Nagao, Kan, Yoshimura, Kenji, Tajikara, Teppei, Eshita, Yoshiyuki, Yano, Yoshitaka, Ichikawa, Tetsuo
Format: Journal Article
Language:English
Published: Japan 2025
Subjects:
Aged
Aged, 80 and over
Dental Plaque - microbiology
Dental Plaque - prevention & control
Dentifrices - chemistry
Dentifrices - pharmacology
Dentifrices - therapeutic use
Female
Humans
Male
Oral Hygiene
Tongue - microbiology
Treatment Outcome
older adults
foam dentifrice
oral hygiene
isodecyl galactosides
ISSN:1880-4926, 1880-4926
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Summary:Oral hygiene is mainly maintained by mechanical plaque removal, but this is often inadequate in older adults. Isodecyl galactosides (ID-Gal) inhibits bacterial co-aggregation and could promote the maintenance and improvement of oral hygiene. In this study, the efficacy of ID-Gal-containing foam dentifrice in oral hygiene among older adults was evaluated. Fifty-six subjects aged 65 years or older visited Tokushima University Hospital and were randomly assigned to interventions using ID-Gal-containing foam dentifrice applied to the dorsum of the tongue, or to controls using their usual dentifrice. Microbiological and clinical oral health parameters were evaluated before, and at 1 and 2 months after the intervention. The intervention group showed significant decreases in black pigment-producing bacteria on the dorsum of the tongue, Fusobacterium, and total bacterial counts on the mucosa below the denture base after 1 month. Additionally, the intervention group showed significant decrease in the Winkle Tongue Coating Index (WTCI) after 2 months. ID-Gal-containing foam dentifrice decreased the number of bacteria by suppressing plaque formation and contributed to a reduction in the number of bacteria on the tongue and the WTCI. Collectively, these results suggest that ID-Gal-containing foam dentifrice is effective in maintaining and improving oral hygiene.
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ISSN:1880-4926
1880-4926
DOI:10.2334/josnusd.24-0387