Female-to-male sex reversal in mice caused by transgenic overexpression of Dmrt1

Genes related to Dmrt1, which encodes a DNA-binding DM domain transcription factor, act as triggers for primary sex determination in a broad range of metazoan species. However, this role is fulfilled in mammals by Sry, a newly evolved gene on the Y chromosome, such that Dmrt1 has become dispensable...

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Vydáno v:	Development (Cambridge) Ročník 142; číslo 6; s. 1083
Hlavní autoři:	Zhao, Liang, Svingen, Terje, Ng, Ee Ting, Koopman, Peter
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	England 15.03.2015
Témata:	Animals Biological Evolution Chromosomes, Artificial, Bacterial Cloning, Molecular Female Gene Expression Regulation, Developmental - genetics Gene Expression Regulation, Developmental - physiology Genetic Vectors - genetics Germ Cells - cytology Leydig Cells - cytology Male Mice Mice, Transgenic - genetics Mice, Transgenic - metabolism Microscopy, Fluorescence Real-Time Polymerase Chain Reaction Sex Determination Processes - genetics Sex Determination Processes - physiology Sex Differentiation - genetics Sex Differentiation - physiology Testis - growth & development Transcription Factors - metabolism Evolution Sox9 Mouse Sex determination DM domain genes
ISSN:	1477-9129, 1477-9129
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