Regulation of the hematopoietic stem cell pool by C-Kit-associated trogocytosis

Hematopoietic stem cells (HSCs) are routinely mobilized from the bone marrow (BM) to the blood circulation for clinical transplantation. However, the precise mechanisms by which individual stem cells exit the marrow are not understood. This study identified cell-extrinsic and molecular determinants...

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Bibliographic Details

Published in:	Science (American Association for the Advancement of Science) Vol. 385; no. 6709; p. eadp2065
Main Authors:	Gao, Xin, Carpenter, Randall S, Boulais, Philip E, Zhang, Dachuan, Marlein, Christopher R, Li, Huihui, Smith, Matthew, Chung, David J, Maryanovich, Maria, Will, Britta, Steidl, Ulrich, Frenette, Paul S
Format:	Journal Article
Language:	English
Published:	United States 09.08.2024
Subjects:	Adult Stem Cells - physiology Animals Antigens, Differentiation Hematopoietic Stem Cell Mobilization - methods Hematopoietic Stem Cells - cytology Hematopoietic Stem Cells - physiology Humans Macrophages - metabolism Mice Mice, Inbred C57BL Proto-Oncogene Proteins c-kit - genetics Proto-Oncogene Proteins c-kit - metabolism Sialic Acid Binding Ig-like Lectin 1 - metabolism Stem Cell Niche Trogocytosis
ISSN:	1095-9203, 1095-9203
Online Access:	Get more information
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