Retinoic acid, meiosis and germ cell fate in mammals

Although mammalian sex is determined genetically, the sex-specific development of germ cells as sperm or oocytes is initiated by cues provided by the gonadal environment. During embryogenesis, germ cells in an ovary enter meiosis, thereby committing to oogenesis. By contrast, germ cells in a testicu...

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Vydané v:Development (Cambridge) Ročník 134; číslo 19; s. 3401
Hlavní autori: Bowles, Josephine, Koopman, Peter
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: England 01.10.2007
Predmet:
Animals
Cell Differentiation
Cell Movement
Cell Proliferation
Female
Germ Cells - drug effects
Germ Cells - physiology
Humans
Male
Meiosis - drug effects
Meiosis - genetics
Meiosis - physiology
Mice
Models, Biological
Sex Differentiation
Sexual Maturation
Testis - cytology
Testis - drug effects
Tretinoin - pharmacology
Tretinoin - physiology
Urogenital System - embryology
ISSN:0950-1991
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Popis
Shrnutí:Although mammalian sex is determined genetically, the sex-specific development of germ cells as sperm or oocytes is initiated by cues provided by the gonadal environment. During embryogenesis, germ cells in an ovary enter meiosis, thereby committing to oogenesis. By contrast, germ cells in a testicular environment do not enter meiosis until puberty. Recent findings indicate that the key to this sex-specific timing of meiosis entry is the presence or absence of the signaling molecule retinoic acid. Although this knowledge clarifies a long-standing mystery in reproductive biology, it also poses many new questions, which we discuss in this review.
Bibliografia:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
ObjectType-Review-3
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ISSN:0950-1991
DOI:10.1242/dev.001107