Low-dose mRNA-1273 COVID-19 vaccine generates durable memory enhanced by cross-reactive T cells

Vaccine-specific CD4 T cell, CD8 T cell, binding antibody, and neutralizing antibody responses to the 25-μg Moderna messenger RNA (mRNA)–1273 vaccine were examined over the course of 7 months after immunization, including in multiple age groups, with a particular interest in assessing whether preexi...

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Bibliographic Details
Published in:	Science (American Association for the Advancement of Science) Vol. 374; no. 6566; p. eabj9853
Main Authors:	Mateus, Jose, Dan, Jennifer M, Zhang, Zeli, Rydyznski Moderbacher, Carolyn, Lammers, Marshall, Goodwin, Benjamin, Sette, Alessandro, Crotty, Shane, Weiskopf, Daniela
Format:	Journal Article
Language:	English
Published:	United States 22.10.2021
Subjects:	2019-nCoV Vaccine mRNA-1273 Adolescent Adult Aged Aged, 80 and over Antibodies, Viral - blood CD4-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - immunology Clinical Trials, Phase I as Topic COVID-19 - immunology COVID-19 - prevention & control COVID-19 Vaccines - administration & dosage COVID-19 Vaccines - immunology Cross Reactions Humans Immunogenicity, Vaccine Immunologic Memory Middle Aged Spike Glycoprotein, Coronavirus - immunology Vaccination Young Adult
ISSN:	1095-9203, 1095-9203
Online Access:	Get more information
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