Acid Resistance of Enamel Subsurface Lesions Remineralized by a Sugar-Free Chewing Gum Containing Casein Phosphopeptide-Amorphous Calcium Phosphate

The aim of this clinical study was to investigate the acid resistance of enamel lesions remineralized in situ by a sugar-free chewing gum containing casein phosphopeptide-amorphous calcium phosphate nanocomplexes (CPP-ACP: Recaldent™). The study utilized a double-blind, randomized, crossover design...

Celý popis

Uložené v:

Podrobná bibliografia
Vydané v:	Caries research Ročník 38; číslo 6; s. 551 - 556
Hlavní autori:	Iijima, Y., Cai, F., Shen, P., Walker, G., Reynolds, C., Reynolds, E.C.
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	Basel, Switzerland S. Karger AG 01.01.2004
Predmet:	Acetic Acid - pharmacology Adult Cariostatic Agents - therapeutic use Caseins - therapeutic use Chewing Gum Cross-Over Studies Dental Enamel - drug effects Double-Blind Method Female Humans Male Middle Aged Original Paper Tooth Demineralization - therapy Tooth Remineralization - methods Xylitol Casein phosphopeptide-stabilized amorphous calcium phosphate Acid resistance Enamel subsurface lesion remineralization
ISSN:	0008-6568, 1421-976X
On-line prístup:	Získať plný text
Tagy:	Pridať tag Žiadne tagy, Buďte prvý, kto otaguje tento záznam!

Abstract	The aim of this clinical study was to investigate the acid resistance of enamel lesions remineralized in situ by a sugar-free chewing gum containing casein phosphopeptide-amorphous calcium phosphate nanocomplexes (CPP-ACP: Recaldent™). The study utilized a double-blind, randomized, crossover design with two treatments: (i) sugar-free gum containing 18.8 mg of CPP-ACP, and (ii) sugar-free gum not containing CPP-ACP as control. Subjects wore removable palatal appliances with insets of human enamel containing demineralized subsurface lesions and chewed the gum for 20 min 4 times per day for 14 days. After each treatment the enamel slabs were removed and half of each lesion challenged with acid in vitro for 8 or 16 h. The level of remineralization was determined using microradiography. The gum containing CPP-ACP produced approximately twice the level of remineralization as the control sugar-free gum. The 8- and 16-hour acid challenge of the lesions remineralized with the control gum resulted in 65.4 and 88.0% reductions, respectively, of deposited mineral, while for the CPP-ACP-remineralized lesions the corresponding reductions were 30.5 and 41.8%. The acid challenge after in situ remineralization for both control and CPP-ACP-treated lesions resulted in demineralization underneath the remineralized zone, indicating that the remineralized mineral was more resistant to subsequent acid challenge. The results show that sugar-free gum containing CPP-ACP is superior to an equivalent gum not containing CPP-ACP in remineralization of enamel subsurface lesions in situ with mineral that is more resistant to subsequent acid challenge.
AbstractList	The aim of this clinical study was to investigate the acid resistance of enamel lesions remineralized in situ by a sugar-free chewing gum containing casein phosphopeptide-amorphous calcium phosphate nanocomplexes (CPP-ACP: Recaldent™). The study utilized a double-blind, randomized, crossover design with two treatments: (i) sugar-free gum containing 18.8 mg of CPP-ACP, and (ii) sugar-free gum not containing CPP-ACP as control. Subjects wore removable palatal appliances with insets of human enamel containing demineralized subsurface lesions and chewed the gum for 20 min 4 times per day for 14 days. After each treatment the enamel slabs were removed and half of each lesion challenged with acid in vitro for 8 or 16 h. The level of remineralization was determined using microradiography. The gum containing CPP-ACP produced approximately twice the level of remineralization as the control sugar-free gum. The 8- and 16-hour acid challenge of the lesions remineralized with the control gum resulted in 65.4 and 88.0% reductions, respectively, of deposited mineral, while for the CPP-ACP-remineralized lesions the corresponding reductions were 30.5 and 41.8%. The acid challenge after in situ remineralization for both control and CPP-ACP-treated lesions resulted in demineralization underneath the remineralized zone, indicating that the remineralized mineral was more resistant to subsequent acid challenge. The results show that sugar-free gum containing CPP-ACP is superior to an equivalent gum not containing CPP-ACP in remineralization of enamel subsurface lesions in situ with mineral that is more resistant to subsequent acid challenge. The aim of this clinical study was to investigate the acid resistance of enamel lesions remineralized in situ by a sugar-free chewing gum containing casein phosphopeptide-amorphous calcium phosphate nanocomplexes (CPP-ACP: Recaldent). The study utilized a double-blind, randomized, crossover design with two treatments: (i) sugar-free gum containing 18.8 mg of CPP-ACP, and (ii) sugar-free gum not containing CPP-ACP as control. Subjects wore removable palatal appliances with insets of human enamel containing demineralized subsurface lesions and chewed the gum for 20 min 4 times per day for 14 days. After each treatment the enamel slabs were removed and half of each lesion challenged with acid in vitro for 8 or 16 h. The level of remineralization was determined using microradiography. The gum containing CPP-ACP produced approximately twice the level of remineralization as the control sugar-free gum. The 8- and 16-hour acid challenge of the lesions remineralized with the control gum resulted in 65.4 and 88.0% reductions, respectively, of deposited mineral, while for the CPP-ACP-remineralized lesions the corresponding reductions were 30.5 and 41.8%. The acid challenge after in situ remineralization for both control and CPP-ACP-treated lesions resulted in demineralization underneath the remineralized zone, indicating that the remineralized mineral was more resistant to subsequent acid challenge. The results show that sugar-free gum containing CPP-ACP is superior to an equivalent gum not containing CPP-ACP in remineralization of enamel subsurface lesions in situ with mineral that is more resistant to subsequent acid challenge.The aim of this clinical study was to investigate the acid resistance of enamel lesions remineralized in situ by a sugar-free chewing gum containing casein phosphopeptide-amorphous calcium phosphate nanocomplexes (CPP-ACP: Recaldent). The study utilized a double-blind, randomized, crossover design with two treatments: (i) sugar-free gum containing 18.8 mg of CPP-ACP, and (ii) sugar-free gum not containing CPP-ACP as control. Subjects wore removable palatal appliances with insets of human enamel containing demineralized subsurface lesions and chewed the gum for 20 min 4 times per day for 14 days. After each treatment the enamel slabs were removed and half of each lesion challenged with acid in vitro for 8 or 16 h. The level of remineralization was determined using microradiography. The gum containing CPP-ACP produced approximately twice the level of remineralization as the control sugar-free gum. The 8- and 16-hour acid challenge of the lesions remineralized with the control gum resulted in 65.4 and 88.0% reductions, respectively, of deposited mineral, while for the CPP-ACP-remineralized lesions the corresponding reductions were 30.5 and 41.8%. The acid challenge after in situ remineralization for both control and CPP-ACP-treated lesions resulted in demineralization underneath the remineralized zone, indicating that the remineralized mineral was more resistant to subsequent acid challenge. The results show that sugar-free gum containing CPP-ACP is superior to an equivalent gum not containing CPP-ACP in remineralization of enamel subsurface lesions in situ with mineral that is more resistant to subsequent acid challenge. The aim of this clinical study was to investigate the acid resistance of enamel lesions remineralized in situ by a sugar-free chewing gum containing casein phosphopeptide-amorphous calcium phosphate nanocomplexes (CPP-ACP: Recaldent(TM)). The study utilized a double-blind, randomized, crossover design with two treatments: (i) sugar-free gum containing 18.8 mg of CPP-ACP, and (ii) sugar-free gum not containing CPP-ACP as control. Subjects wore removable palatal appliances with insets of human enamel containing demineralized subsurface lesions and chewed the gum for 20 min 4 times per day for 14 days. After each treatment the enamel slabs were removed and half of each lesion challenged with acid in vitro for 8 or 16 h. The level of remineralization was determined using microradiography. The gum containing CPP-ACP produced approximately twice the level of remineralization as the control sugar-free gum. The 8- and 16-hour acid challenge of the lesions remineralized with the control gum resulted in 65.4 and 88.0% reductions, respectively, of deposited mineral, while for the CPP-ACP-remineralized lesions the corresponding reductions were 30.5 and 41.8%. The acid challenge after in situ remineralization for both control and CPP-ACP-treated lesions resulted in demineralization underneath the remineralized zone, indicating that the remineralized mineral was more resistant to subsequent acid challenge. The results show that sugar-free gum containing CPP-ACP is superior to an equivalent gum not containing CPP-ACP in remineralization of enamel subsurface lesions in situ with mineral that is more resistant to subsequent acid challenge. Copyright © 2004 S. Karger AG, Basel The aim of this clinical study was to investigate the acid resistance of enamel lesions remineralized in situ by a sugar-free chewing gum containing casein phosphopeptide-amorphous calcium phosphate nanocomplexes (CPP-ACP: Recaldent). The study utilized a double-blind, randomized, crossover design with two treatments: (i) sugar-free gum containing 18.8 mg of CPP-ACP, and (ii) sugar-free gum not containing CPP-ACP as control. Subjects wore removable palatal appliances with insets of human enamel containing demineralized subsurface lesions and chewed the gum for 20 min 4 times per day for 14 days. After each treatment the enamel slabs were removed and half of each lesion challenged with acid in vitro for 8 or 16 h. The level of remineralization was determined using microradiography. The gum containing CPP-ACP produced approximately twice the level of remineralization as the control sugar-free gum. The 8- and 16-hour acid challenge of the lesions remineralized with the control gum resulted in 65.4 and 88.0% reductions, respectively, of deposited mineral, while for the CPP-ACP-remineralized lesions the corresponding reductions were 30.5 and 41.8%. The acid challenge after in situ remineralization for both control and CPP-ACP-treated lesions resulted in demineralization underneath the remineralized zone, indicating that the remineralized mineral was more resistant to subsequent acid challenge. The results show that sugar-free gum containing CPP-ACP is superior to an equivalent gum not containing CPP-ACP in remineralization of enamel subsurface lesions in situ with mineral that is more resistant to subsequent acid challenge.
Author	Walker, G. Reynolds, C. Cai, F. Iijima, Y. Shen, P. Reynolds, E.C.
Author_xml	– sequence: 1 givenname: Y. surname: Iijima fullname: Iijima, Y. – sequence: 2 givenname: F. surname: Cai fullname: Cai, F. – sequence: 3 givenname: P. surname: Shen fullname: Shen, P. – sequence: 4 givenname: G. surname: Walker fullname: Walker, G. – sequence: 5 givenname: C. surname: Reynolds fullname: Reynolds, C. – sequence: 6 givenname: E.C. surname: Reynolds fullname: Reynolds, E.C.
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/15528910$$D View this record in MEDLINE/PubMed
BookMark	eNptkV9rFDEUxYNU7Lb64LMgoQ-CD2OT-ZNNHpdhW4UFpSr4NtzJ3OymziTTZAapX8MvbNZtK5TmJdx7fudyk3NCjpx3SMhrzj5wXqlzlo5klayekQUvc56ppfhxRBb7diYqIY_JSYzXjPFSCPmCHPOqyqXibEH-rLTt6BVGGydwGqk3dO1gwJ5-nds4BwOpuUm6dzFxg3UYoLe_saPtLYVEbSFkFwGR1jv8Zd2WXs4Drb2bwLp9WUNE6-iXnY_jzo84TrbDbDX4kMo5Jr3XNlkOAEz4kjw30Ed8dXefku8X62_1x2zz-fJTvdpkOr1xyjrGTWUMLKuyVC0yqYCjYmCYNhyKqutMDiovlDCFkLJsWy6WrdLClJBrVhan5N1h7hj8zYxxagYbNfY9OEyLNWLJypLnPIFnj8BrPweXdmvynCVASZmgt3fQ3A7YNWOwA4Tb5v6vE_D-AOjgYwxo_iOs2efYPOSY2PNHrLYTTCmEKYDtn3S8OTh-QthieJh9r549qdZX639AM3am-Ath6bQW
CODEN	CAREBK
CitedBy_id	crossref_primary_10_1007_s00784_017_2314_9 crossref_primary_10_1186_s12903_019_0977_0 crossref_primary_10_1016_j_ajodo_2010_09_027 crossref_primary_10_1016_j_archoralbio_2014_02_002 crossref_primary_10_14219_jada_archive_2008_0278 crossref_primary_10_1186_s43014_024_00280_2 crossref_primary_10_7759_cureus_44795 crossref_primary_10_1159_000379750 crossref_primary_10_1016_j_jdent_2017_08_008 crossref_primary_10_1177_0022034510376046 crossref_primary_10_2341_13_220_L crossref_primary_10_1016_j_jdent_2009_07_011 crossref_primary_10_4103_1735_3327_369626 crossref_primary_10_1007_s00784_017_2175_2 crossref_primary_10_1111_idh_12542 crossref_primary_10_1016_j_jnma_2017_02_009 crossref_primary_10_1016_j_micpath_2018_06_038 crossref_primary_10_1016_j_ajodo_2007_06_021 crossref_primary_10_1016_j_jdent_2014_08_008 crossref_primary_10_4103_tdj_tdj_59_23 crossref_primary_10_1155_2011_725320 crossref_primary_10_1007_s40368_016_0232_1 crossref_primary_10_4103_ijdr_IJDR_238_19 crossref_primary_10_2341_10_280_L crossref_primary_10_1093_ejo_cju031 crossref_primary_10_1016_j_jdent_2020_103423 crossref_primary_10_1186_1472_6831_14_28 crossref_primary_10_1016_j_archoralbio_2024_106156 crossref_primary_10_1186_s13643_019_1253_8 crossref_primary_10_1007_s40496_016_0083_1 crossref_primary_10_1111_j_1834_7819_2008_00061_x crossref_primary_10_1007_s00784_013_0989_0 crossref_primary_10_1111_j_1834_7819_2009_01127_x crossref_primary_10_1016_j_ajodo_2012_09_007 crossref_primary_10_4103_jpbs_jpbs_1148_23 crossref_primary_10_1016_j_jdent_2008_01_005 crossref_primary_10_1002_sca_21077 crossref_primary_10_1080_00016350903160563 crossref_primary_10_1111_j_1834_7819_2008_00072_x crossref_primary_10_1063_1_2927386 crossref_primary_10_1111_j_1834_7819_2007_00006_x crossref_primary_10_1007_s12011_012_9328_6 crossref_primary_10_3390_jfb16010023 crossref_primary_10_1117_1_3210780 crossref_primary_10_1111_ipd_12268 crossref_primary_10_1002_jemt_23857 crossref_primary_10_1007_s10989_007_9105_0 crossref_primary_10_1016_j_jdent_2008_12_005 crossref_primary_10_1111_j_1875_595X_2011_00059_x crossref_primary_10_1016_j_ijadhadh_2016_01_007 crossref_primary_10_2341_07_136 crossref_primary_10_1177_0895937409335620 crossref_primary_10_1007_s10856_013_4898_1 crossref_primary_10_1111_j_1365_263X_2008_00920_x crossref_primary_10_1038_s41598_023_27390_0 crossref_primary_10_1039_D1BM01239H crossref_primary_10_14219_jada_archive_2008_0352 crossref_primary_10_1016_j_jdent_2005_06_005 crossref_primary_10_17796_1053_4628_40_5_404 crossref_primary_10_4103_1735_3327_270778 crossref_primary_10_1177_0022034512453845 crossref_primary_10_1111_j_1834_7819_2007_tb00478_x crossref_primary_10_1016_j_ajodo_2006_09_043 crossref_primary_10_1111_jerd_13239 crossref_primary_10_5762_KAIS_2014_15_9_5602 crossref_primary_10_1016_j_archoralbio_2010_05_002 crossref_primary_10_1016_j_colsurfb_2024_113966 crossref_primary_10_1016_j_drudis_2006_02_003 crossref_primary_10_1259_dmfr_15857365 crossref_primary_10_1016_j_actbio_2010_06_031 crossref_primary_10_1016_j_dental_2016_07_004 crossref_primary_10_1016_j_jdent_2009_06_003 crossref_primary_10_1016_j_jdent_2007_08_007 crossref_primary_10_1111_j_1834_7819_2008_00063_x crossref_primary_10_1177_154405910808700420 crossref_primary_10_1038_nnano_2010_83 crossref_primary_10_1163_156856206776374124 crossref_primary_10_1111_adj_12624 crossref_primary_10_1159_000530638 crossref_primary_10_3233_THC_230722 crossref_primary_10_1016_j_jmbbm_2013_08_004 crossref_primary_10_1159_000363073 crossref_primary_10_1053_j_sodo_2008_03_006 crossref_primary_10_1053_j_sodo_2008_03_007 crossref_primary_10_1155_2017_7834905 crossref_primary_10_1007_s11282_015_0218_4 crossref_primary_10_1111_j_1834_7819_2006_tb00445_x crossref_primary_10_1093_ejo_cjq183 crossref_primary_10_1016_j_jds_2012_09_001 crossref_primary_10_1016_j_jdent_2008_11_015 crossref_primary_10_1038_s41598_025_14005_z crossref_primary_10_1016_j_jdent_2011_05_002 crossref_primary_10_1038_sj_bdj_2011_51 crossref_primary_10_1007_s10266_024_00914_4 crossref_primary_10_1016_j_ajodo_2010_07_007 crossref_primary_10_1016_S0300_5712_14_50003_6 crossref_primary_10_1186_s12903_016_0160_9 crossref_primary_10_1177_0022034509347168 crossref_primary_10_1016_j_ajodo_2016_02_026 crossref_primary_10_1557_jmr_2013_292
Cites_doi	10.1177%2F00220345950740060601 10.1006%2Fjcis.1999.6407 10.1159%2F000261026 10.1177%2F08959374960100021801 10.1016%2FS0022-5320%2863%2980017-9 10.1177%2F00220345970760091101 10.1111%2Fj.1754-4505.1998.tb01353.x 10.1007%2Fs002239900628 10.1111%2Fj.1834-7819.1972.tb04977.x 10.1177%2F154405910308200311 10.1177%2F00220345010800120801
ContentType	Journal Article
Copyright	2004 S. Karger AG, Basel 2004 S. Karger AG, Basel. Copyright (c) 2004 S. Karger AG, Basel
Copyright_xml	– notice: 2004 S. Karger AG, Basel – notice: 2004 S. Karger AG, Basel. – notice: Copyright (c) 2004 S. Karger AG, Basel
DBID	AAYXX CITATION CGR CUY CVF ECM EIF NPM 3V. 7QL 7QO 7QP 7RV 7U7 7X7 7XB 88E 8AO 8FD 8FI 8FJ 8FK ABUWG AFKRA BENPR C1K CCPQU FR3 FYUFA GHDGH K9. KB0 M0S M1P NAPCQ P64 PHGZM PHGZT PJZUB PKEHL PPXIY PQEST PQQKQ PQUKI PRINS RC3 S0X 7X8
DOI	10.1159/000080585
DatabaseName	CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed ProQuest Central (Corporate) Bacteriology Abstracts (Microbiology B) Biotechnology Research Abstracts Calcium & Calcified Tissue Abstracts Nursing & Allied Health Database Toxicology Abstracts Health & Medical Collection ProQuest Central (purchase pre-March 2016) Medical Database (Alumni Edition) ProQuest Pharma Collection Technology Research Database Hospital Premium Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) ProQuest Central (Alumni Edition) ProQuest Central UK/Ireland ProQuest Central Environmental Sciences and Pollution Management ProQuest One Community College Engineering Research Database Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Health & Medical Complete (Alumni) Nursing & Allied Health Database (Alumni Edition) Health & Medical Collection (Alumni Edition) Medical Database Nursing & Allied Health Premium Biotechnology and BioEngineering Abstracts ProQuest Central Premium ProQuest One Academic (New) ProQuest Health & Medical Research Collection ProQuest One Academic Middle East (New) ProQuest One Health & Nursing ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Academic (retired) ProQuest One Academic UKI Edition ProQuest Central China Genetics Abstracts SIRS Editorial MEDLINE - Academic
DatabaseTitle	CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) Technology Research Database ProQuest One Academic Middle East (New) SIRS Editorial ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) ProQuest One Community College ProQuest One Health & Nursing ProQuest Pharma Collection ProQuest Central China Environmental Sciences and Pollution Management ProQuest Central ProQuest Health & Medical Research Collection Genetics Abstracts Health Research Premium Collection Biotechnology Research Abstracts Health and Medicine Complete (Alumni Edition) Bacteriology Abstracts (Microbiology B) Health & Medical Research Collection ProQuest Central (New) ProQuest Medical Library (Alumni) Toxicology Abstracts ProQuest One Academic Eastern Edition ProQuest Nursing & Allied Health Source ProQuest Hospital Collection Health Research Premium Collection (Alumni) ProQuest Hospital Collection (Alumni) Biotechnology and BioEngineering Abstracts Nursing & Allied Health Premium ProQuest Health & Medical Complete ProQuest Medical Library ProQuest One Academic UKI Edition ProQuest Nursing & Allied Health Source (Alumni) Engineering Research Database ProQuest One Academic Calcium & Calcified Tissue Abstracts ProQuest One Academic (New) ProQuest Central (Alumni) MEDLINE - Academic
DatabaseTitleList	CrossRef MEDLINE - Academic Technology Research Database MEDLINE
Database_xml	– sequence: 1 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: 7RV name: Nursing & Allied Health Database url: https://search.proquest.com/nahs sourceTypes: Aggregation Database
DeliveryMethod	fulltext_linktorsrc
Discipline	Dentistry
EISSN	1421-976X
EndPage	556
ExternalDocumentID	732349281 15528910 10_1159_000080585 80585
Genre	Clinical Trial Randomized Controlled Trial Research Support, Non-U.S. Gov't Journal Article
GroupedDBID	--- 0R~ 0~5 0~B 29B 30W 329 34H 3O. 3V. 4.4 53G 5GY 5RE 6J9 6P2 6PF 7RV 7X7 88E 8AO 8FI 8FJ 8FW 8UI AALGM AAWTL AAYIC ABDBF ABJNI ABPAZ ABUWG ACCCW ACGFO ACGFS ACIWK ACPRK ACPSR ADAGL ADBBV ADFRT AENEX AEYAO AFFNX AFJJK AFKRA AFRAH AHMBA ALDHI ALIPV ALMA_UNASSIGNED_HOLDINGS AZPMC BENPR BKEYQ BPHCQ BVXVI C45 CAG CCPQU COF CS3 CYUIP DU5 E0A EBS EJD EX3 F5P FB. FYUFA GK1 HMCUK HZ~ I4R IAO IHR IY7 KUZGX M1P N9A NAPCQ O1H O9- OVD P2P PCD PQQKQ PROAC PSQYO RIG RKO RXVBD S0X TEORI UJ6 UKHRP WH7 WOW ZGI AAYXX ABBTS ABWCG ACQXL ACUHS AFFHD AFSIO AHFRZ CITATION ITC IVC PHGZM PHGZT PJZUB PPXIY CGR CUY CVF ECM EIF NPM PKN 7QL 7QO 7QP 7U7 7XB 8FD 8FK C1K FR3 K9. P64 PKEHL PQEST PQUKI PRINS RC3 7X8 PUEGO
ID	FETCH-LOGICAL-c421t-d01f5ffa75449be089a1e90af0cf1a35ddf2a92396f36884bb167b9c6f4a2c043
IEDL.DBID	BENPR
ISICitedReferencesCount	167
ISICitedReferencesURI	http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000224897200007&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
ISSN	0008-6568
IngestDate	Wed Oct 01 14:38:36 EDT 2025 Mon Nov 24 00:33:59 EST 2025 Wed Feb 19 01:50:26 EST 2025 Sat Nov 29 08:00:55 EST 2025 Tue Nov 18 21:09:57 EST 2025 Thu Aug 29 12:04:22 EDT 2024 Thu Sep 05 17:58:12 EDT 2024
IsPeerReviewed	true
IsScholarly	true
Issue	6
Keywords	Casein phosphopeptide-stabilized amorphous calcium phosphate Acid resistance Enamel subsurface lesion remineralization
Language	English
License	Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. https://www.karger.com/Services/SiteLicenses 2004 S. Karger AG, Basel.
LinkModel	DirectLink
MergedId	FETCHMERGED-LOGICAL-c421t-d01f5ffa75449be089a1e90af0cf1a35ddf2a92396f36884bb167b9c6f4a2c043
Notes	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 14 content type line 23 ObjectType-Undefined-3
PMID	15528910
PQID	220213988
PQPubID	34578
PageCount	6
ParticipantIDs	crossref_primary_10_1159_000080585 proquest_miscellaneous_67044121 crossref_citationtrail_10_1159_000080585 karger_primary_80585 pubmed_primary_15528910 proquest_journals_220213988
PublicationCentury	2000
PublicationDate	2004-01-01
PublicationDateYYYYMMDD	2004-01-01
PublicationDate_xml	– month: 01 year: 2004 text: 2004-01-01 day: 01
PublicationDecade	2000
PublicationPlace	Basel, Switzerland
PublicationPlace_xml	– name: Basel, Switzerland – name: Switzerland – name: Basel
PublicationTitle	Caries research
PublicationTitleAlternate	Caries Res
PublicationYear	2004
Publisher	S. Karger AG
Publisher_xml	– name: S. Karger AG
References	Malcolm AS: A microradiographic apparatus. Aust Dent J 1972;17:454-460.451198210.1111%2Fj.1834-7819.1972.tb04977.x LeGeros RZ, Sakae T, Bautista C, Retino M, LeGeros JP: Magnesium and carbonate in enamel and synthetic apatites. Adv Dent Res 1996;10:225-231.920634110.1177%2F08959374960100021801 White DJ: Use of synthetic-polymer gels for artificial carious lesion preparation. Caries Res 1987;21:228-242.347134610.1159%2F000261026 Angmar B, Carlström D, Glas JE: Studies on the ultrastructure of dental enamel. J Ultrastruct Res 1963;8:12-23.1401318410.1016%2FS0022-5320%2863%2980017-9 Shen P, Cai F, Nowicki A, Vincent J, Reynolds EC: Remineralization of enamel subsurface lesions by sugar-free chewing gum containing casein phosphopeptide-amorphous calcium phosphate. J Dent Res 2001;80:2066-2070.1180876310.1177%2F00220345010800120801 Baig AA, Fox JL, Young RA, Wang Z, Hsu J, Higuchi WI, Chhettry A, Zhuang H, Otsuka M: Relationships among carbonated apatite solubility, crystallite size, and microstrain parameters. Calcif Tissue Int 1999;64:437-439.1020342110.1007%2Fs002239900628 Reynolds EC: Anticariogenic complexes of amorphous calcium phosphate stabilized by casein phosphopeptides: A review. Spec Care Dentist 1998;8:8-16.979130210.1111%2Fj.1754-4505.1998.tb01353.x Reynolds EC, Black CL, Cai F, Cross KJ, Eakins D, Huq NL, Morgan MV, Nowicki A, Perich JW, Riley PF, Shen P, Talbo G, Webber FW: Advances in enamel remineralization: Anticariogenic casein phosphopeptide - amorphous calcium phosphate. J Clin Dent 1999;10:86-88. Reynolds EC: Remineralization of enamel sub-surface lesions by casein phosphopeptide-stabilized calcium phosphate solutions. J Dent Res 1997;76:1587-1595.929449310.1177%2F00220345970760091101 Reynolds EC, Cai F, Shen P, Walker GD: Retention in plaque and remineralization of enamel lesions by various forms of calcium in a mouthrinse or sugar-free chewing gum. J Dent Res 2003;82:206-211.1259855010.1177%2F154405910308200311 Reynolds EC, Cain CJ, Webber FL, Black CL, Riley PF, Johnson IH, Perich JW: Anticariogenicity of calcium phosphate complexes of tryptic casein phosphopeptides in the rat. J Dent Res 1995;74:1272-1279.762933610.1177%2F00220345950740060601 Sokal RR, Rohlf FJ: Biometry. San Francisco, Freeman, 1969. Nelson DG: The influence of carbonate on the atomic structure and reactivity of hydroxyapatite. J Dent Res 1981;60:1621-1629.6943172 Shellis RP, Lee AR, Wilson RM: Observations on the apparent solubility of carbonated-apatites. J Colloid Interface Sci 1999;218:351-358.1050236610.1006%2Fjcis.1999.6407 ref8 ref7 ref9 ref4 ref3 ref6 ref11 ref5 ref10 ref2 ref1
References_xml	– reference: White DJ: Use of synthetic-polymer gels for artificial carious lesion preparation. Caries Res 1987;21:228-242.347134610.1159%2F000261026 – reference: Shellis RP, Lee AR, Wilson RM: Observations on the apparent solubility of carbonated-apatites. J Colloid Interface Sci 1999;218:351-358.1050236610.1006%2Fjcis.1999.6407 – reference: Baig AA, Fox JL, Young RA, Wang Z, Hsu J, Higuchi WI, Chhettry A, Zhuang H, Otsuka M: Relationships among carbonated apatite solubility, crystallite size, and microstrain parameters. Calcif Tissue Int 1999;64:437-439.1020342110.1007%2Fs002239900628 – reference: Shen P, Cai F, Nowicki A, Vincent J, Reynolds EC: Remineralization of enamel subsurface lesions by sugar-free chewing gum containing casein phosphopeptide-amorphous calcium phosphate. J Dent Res 2001;80:2066-2070.1180876310.1177%2F00220345010800120801 – reference: Reynolds EC, Cai F, Shen P, Walker GD: Retention in plaque and remineralization of enamel lesions by various forms of calcium in a mouthrinse or sugar-free chewing gum. J Dent Res 2003;82:206-211.1259855010.1177%2F154405910308200311 – reference: Sokal RR, Rohlf FJ: Biometry. San Francisco, Freeman, 1969. – reference: Reynolds EC, Cain CJ, Webber FL, Black CL, Riley PF, Johnson IH, Perich JW: Anticariogenicity of calcium phosphate complexes of tryptic casein phosphopeptides in the rat. J Dent Res 1995;74:1272-1279.762933610.1177%2F00220345950740060601 – reference: Reynolds EC: Anticariogenic complexes of amorphous calcium phosphate stabilized by casein phosphopeptides: A review. Spec Care Dentist 1998;8:8-16.979130210.1111%2Fj.1754-4505.1998.tb01353.x – reference: Malcolm AS: A microradiographic apparatus. Aust Dent J 1972;17:454-460.451198210.1111%2Fj.1834-7819.1972.tb04977.x – reference: Reynolds EC, Black CL, Cai F, Cross KJ, Eakins D, Huq NL, Morgan MV, Nowicki A, Perich JW, Riley PF, Shen P, Talbo G, Webber FW: Advances in enamel remineralization: Anticariogenic casein phosphopeptide - amorphous calcium phosphate. J Clin Dent 1999;10:86-88. – reference: Nelson DG: The influence of carbonate on the atomic structure and reactivity of hydroxyapatite. J Dent Res 1981;60:1621-1629.6943172 – reference: Reynolds EC: Remineralization of enamel sub-surface lesions by casein phosphopeptide-stabilized calcium phosphate solutions. J Dent Res 1997;76:1587-1595.929449310.1177%2F00220345970760091101 – reference: Angmar B, Carlström D, Glas JE: Studies on the ultrastructure of dental enamel. J Ultrastruct Res 1963;8:12-23.1401318410.1016%2FS0022-5320%2863%2980017-9 – reference: LeGeros RZ, Sakae T, Bautista C, Retino M, LeGeros JP: Magnesium and carbonate in enamel and synthetic apatites. Adv Dent Res 1996;10:225-231.920634110.1177%2F08959374960100021801 – ident: ref8 doi: 10.1177%2F00220345950740060601 – ident: ref9 doi: 10.1006%2Fjcis.1999.6407 – ident: ref11 doi: 10.1159%2F000261026 – ident: ref3 doi: 10.1177%2F08959374960100021801 – ident: ref1 doi: 10.1016%2FS0022-5320%2863%2980017-9 – ident: ref5 doi: 10.1177%2F00220345970760091101 – ident: ref6 doi: 10.1111%2Fj.1754-4505.1998.tb01353.x – ident: ref2 doi: 10.1007%2Fs002239900628 – ident: ref4 doi: 10.1111%2Fj.1834-7819.1972.tb04977.x – ident: ref7 doi: 10.1177%2F154405910308200311 – ident: ref10 doi: 10.1177%2F00220345010800120801
SSID	ssj0014668
Score	2.16049
Snippet	The aim of this clinical study was to investigate the acid resistance of enamel lesions remineralized in situ by a sugar-free chewing gum containing casein...
SourceID	proquest pubmed crossref karger
SourceType	Aggregation Database Index Database Enrichment Source Publisher
StartPage	551
SubjectTerms	Acetic Acid - pharmacology Adult Cariostatic Agents - therapeutic use Caseins - therapeutic use Chewing Gum Cross-Over Studies Dental Enamel - drug effects Double-Blind Method Female Humans Male Middle Aged Original Paper Tooth Demineralization - therapy Tooth Remineralization - methods Xylitol
Title	Acid Resistance of Enamel Subsurface Lesions Remineralized by a Sugar-Free Chewing Gum Containing Casein Phosphopeptide-Amorphous Calcium Phosphate
URI	https://karger.com/doi/10.1159/000080585 https://www.ncbi.nlm.nih.gov/pubmed/15528910 https://www.proquest.com/docview/220213988 https://www.proquest.com/docview/67044121
Volume	38
WOSCitedRecordID	wos000224897200007&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
hasFullText	1
inHoldings	1
isFullTextHit
isPrint
journalDatabaseRights	– providerCode: PRVPQU databaseName: Health & Medical Collection customDbUrl: eissn: 1421-976X dateEnd: 20151031 omitProxy: false ssIdentifier: ssj0014668 issn: 0008-6568 databaseCode: 7X7 dateStart: 19970101 isFulltext: true titleUrlDefault: https://search.proquest.com/healthcomplete providerName: ProQuest – providerCode: PRVPQU databaseName: Nursing & Allied Health Database customDbUrl: eissn: 1421-976X dateEnd: 20151031 omitProxy: false ssIdentifier: ssj0014668 issn: 0008-6568 databaseCode: 7RV dateStart: 19970101 isFulltext: true titleUrlDefault: https://search.proquest.com/nahs providerName: ProQuest – providerCode: PRVPQU databaseName: ProQuest Central customDbUrl: eissn: 1421-976X dateEnd: 20151031 omitProxy: false ssIdentifier: ssj0014668 issn: 0008-6568 databaseCode: BENPR dateStart: 19970101 isFulltext: true titleUrlDefault: https://www.proquest.com/central providerName: ProQuest
link	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1Lj9MwELbY7kpw4bU8ysJiIQ5crHVSJ7FPqJQWDqiqKkC9RX7SiDYpyRYEf4M_zDhxA0LAhUsU2ePIyow939ij-RB6CnFxAqieEg7olTDFBFFKG2KEyNQI_IGKVUs2kc3nfLUSi5Cb04S0ysOe2G7UptL-jPwihigd0Arnz3efiCeN8pergUHjCB37QmVsgI5fTOeLZX-NwNK024opJwBceCgtBC78ogNLiedQ_sUhnXz0-df13-Fm63ZmN_5zwjfR9YA38bgzkFvoii1vo6svfY6Qp3k7Rd_HujB4aRsPJMECcOXwtJRbu8F-U9nXTkLjG-tP1RqQ2xZtnerimzVYfcUSpD7Imsxqa_Fkbb-AK8Sv9lvsy1517BN4Ap6yKPFiXTW7dbXzeTTGkvG2Ah1X-wb6N7qAIZ0AgN876N1s-nbymgSmBqJZHF0SQyOXOCd9NT2hLOVCRlZQ6ah2kRwlxrhYApQUqRulnDOlojRTQqeOyVhTNrqLBmVV2vsIRzqmmfEU6CphEkZzsCJ4jbQVzGk7RM8O6sp1KGPu2TQ2eRvOJCLvNTtET3rRXVe7409Cp53Oe5HQfPZb82Q5bXvynXHQe9B5HtZ8k_cKH6LHfS8sVn8DI0sL_zNPMwrwM46G6F5nVD_nlSQQ-kb0wT-_fIaudZlD_gjoIRpc1nv7CJ3oz2Az9Tk6ypbv_XOVtU9-HtbDD3nYEIo
linkProvider	ProQuest
linkToHtml	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1bb9MwFLbGmDReuI1LGTALgcSLtTjNxX5AqOpaNq1UUzXQ3oKvNKJNQrIyjb_B7-A_cpykASHgbQ-8RfZJFDmfj79jn5wPoecQF4fA6j3CgL2SQAacSKk00ZzHsg_rgfRlLTYRT6fs7IyfbKDv639hXFrl2ifWjlrnyu2R7_sQpQNbYex18Zk40Sh3uLpW0GhQcWwuLyBiq14dHcDnfeH749Hp8JC0ogJEBT49J9qjNrRWuMJvXBqPcUEN94T1lKWiH2ptfQGsh0e2HzEWSEmjWHIV2UD4ygv68Nxr6Dq4ceoyyOLZ--7QIoiixvF7jABNYm0hIyAM-w01C51i8y_L39Ynl-1d_p3c1ovc-NZ_Njy30c2WTeNBA_87aMNkd9H2gcuAciJ2O-jbQKUaz0zlaDLgG-cWjzKxNAvsXOaqtAIaJ8btGVZgt0zrKtzpV6OxvMQCrD6KkoxLY_Bwbi5gocdvVkvsino12hp4CDwgzfDJPK-KeV64LCFtyGCZA4LzVQX9C5XCLY0BUPt76N2VjMl9tJnlmXmIMFW-F2sn8C7DQMDdDOYIXFJleGCV6aGXa3gkqi3S7rRCFkkdrIU86ZDUQ88606KpTPIno50GY51J27z7W_NwNqp7kkJb6F1jLGk9WpV0AOuhva4XXJE7XxKZgfFMotgDcu3THnrQgPjne4UhBPbUe_TPJ--h7cPTt5NkcjQ93kU3mhwpt9n1GG2elyvzBG2pL4Cf8mk97zD6cNVI_gGgkWo-
linkToPdf	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1Lb9NAEB6VtKJceJVHKNAVAonLqrbj1x4QCnlA1SqKIpB6M_skURPb2A1V-Rv8Gv4ds7ZjEAJuPXCzdseWtf529pvd8XwAzzEuDpDVOzRG9kp94TMqhFRUMRaJHq4HwhOV2EQ0mcSnp2y6Bd83_8LYtMqNT6wctcqk3SM_9DBKR7aC8ZppsiKmw_Hr_DO1AlL2oHWjplEj5FhfXmD0Vr46GuKnfuF549H7wTvaCAxQ6XvuOVWOawJjuC0Cx4R2YsZdzRxuHGlc3guUMh5HBsRC0wvj2BfCDSPBZGh87knH7-Fzr8F2hBwj6MD2m9FkOmuPMPwwrJcBJ6ZImuKmrBHSh8OaqAVWv_mXxXDnzOZ-F3-nutWSN771Hw_WbbjZ8GzSryfGHdjS6V3YHdrcKCtvtwff-nKhyEyXlkAj8klmyCjlK70k1pmuC8Ox8UTb3cQS7VaLqj734qtWRFwSjlafeEHHhdZkMNcXSAHI2_WK2HJfteoGGSBDWKRkOs_KfJ7lNn9IadpfZYjtbF1i_1Iu8JbaAEn_PfhwJWNyHzppluqHQFzpOZGy0u8i8DneHePswUtXauYbqbvwcgOVRDbl262KyDKpwriAJS2quvCsNc3rmiV_Mtqr8daaNM37vzUPZqOqJ8mVwd4N3pLG15VJC7YuHLS96KTsyRNPNY5nEkYO0m7P7cKDGtA_3ysIMOR3nUf_fPIBXEcAJydHk-N9uFEnT9ldsMfQOS_W-gnsyC8In-JpMwkJfLxqKP8AznR0Mg
openUrl	ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Acid+resistance+of+enamel+subsurface+lesions+remineralized+by+a+sugar-free+chewing+gum+containing+casein+phosphopeptide-amorphous+calcium+phosphate&rft.jtitle=Caries+research&rft.au=Iijima%2C+Y&rft.au=Cai%2C+F&rft.au=Shen%2C+P&rft.au=Walker%2C+G&rft.date=2004-01-01&rft.issn=0008-6568&rft.volume=38&rft.issue=6&rft.spage=551&rft_id=info:doi/10.1159%2F000080585&rft_id=info%3Apmid%2F15528910&rft.externalDocID=15528910
thumbnail_l	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0008-6568&client=summon
thumbnail_m	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0008-6568&client=summon
thumbnail_s	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0008-6568&client=summon