Acid Resistance of Enamel Subsurface Lesions Remineralized by a Sugar-Free Chewing Gum Containing Casein Phosphopeptide-Amorphous Calcium Phosphate

The aim of this clinical study was to investigate the acid resistance of enamel lesions remineralized in situ by a sugar-free chewing gum containing casein phosphopeptide-amorphous calcium phosphate nanocomplexes (CPP-ACP: Recaldent™). The study utilized a double-blind, randomized, crossover design...

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Bibliographic Details
Published in:Caries research Vol. 38; no. 6; pp. 551 - 556
Main Authors: Iijima, Y., Cai, F., Shen, P., Walker, G., Reynolds, C., Reynolds, E.C.
Format: Journal Article
Language:English
Published: Basel, Switzerland S. Karger AG 01.01.2004
Subjects:
Acetic Acid - pharmacology
Adult
Cariostatic Agents - therapeutic use
Caseins - therapeutic use
Chewing Gum
Cross-Over Studies
Dental Enamel - drug effects
Double-Blind Method
Female
Humans
Male
Middle Aged
Original Paper
Tooth Demineralization - therapy
Tooth Remineralization - methods
Xylitol
Casein phosphopeptide-stabilized amorphous calcium phosphate
Acid resistance
Enamel subsurface lesion remineralization
ISSN:0008-6568, 1421-976X
Online Access:Get full text
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Summary:The aim of this clinical study was to investigate the acid resistance of enamel lesions remineralized in situ by a sugar-free chewing gum containing casein phosphopeptide-amorphous calcium phosphate nanocomplexes (CPP-ACP: Recaldent™). The study utilized a double-blind, randomized, crossover design with two treatments: (i) sugar-free gum containing 18.8 mg of CPP-ACP, and (ii) sugar-free gum not containing CPP-ACP as control. Subjects wore removable palatal appliances with insets of human enamel containing demineralized subsurface lesions and chewed the gum for 20 min 4 times per day for 14 days. After each treatment the enamel slabs were removed and half of each lesion challenged with acid in vitro for 8 or 16 h. The level of remineralization was determined using microradiography. The gum containing CPP-ACP produced approximately twice the level of remineralization as the control sugar-free gum. The 8- and 16-hour acid challenge of the lesions remineralized with the control gum resulted in 65.4 and 88.0% reductions, respectively, of deposited mineral, while for the CPP-ACP-remineralized lesions the corresponding reductions were 30.5 and 41.8%. The acid challenge after in situ remineralization for both control and CPP-ACP-treated lesions resulted in demineralization underneath the remineralized zone, indicating that the remineralized mineral was more resistant to subsequent acid challenge. The results show that sugar-free gum containing CPP-ACP is superior to an equivalent gum not containing CPP-ACP in remineralization of enamel subsurface lesions in situ with mineral that is more resistant to subsequent acid challenge.
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ISSN:0008-6568
1421-976X
DOI:10.1159/000080585