Bacterial vaginosis is a strong predictor of Neisseria gonorrhoeae and Chlamydia trachomatis infection

To evaluate whether bacterial vaginosis predicts the acquisition of sexually transmitted diseases (STDs), we studied 255 nonpregnant female subjects aged 15-30 who reported recent sexual contact with a male partner in whom either gonococcal or chlamydial urethritis or nongonococcal urethritis was di...

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Veröffentlicht in:Clinical infectious diseases Jg. 36; H. 5; S. 663
Hauptverfasser: Wiesenfeld, Harold C, Hillier, Sharon L, Krohn, Marijane A, Landers, Daniel V, Sweet, Richard L
Format: Journal Article
Sprache:Englisch
Veröffentlicht: United States 01.03.2003
Schlagworte:
Adolescent
Adult
Chlamydia Infections - diagnosis
Chlamydia trachomatis
Female
Gonorrhea - diagnosis
Humans
Male
Neisseria gonorrhoeae
Prognosis
Vaginosis, Bacterial
ISSN:1537-6591, 1537-6591
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Zusammenfassung:To evaluate whether bacterial vaginosis predicts the acquisition of sexually transmitted diseases (STDs), we studied 255 nonpregnant female subjects aged 15-30 who reported recent sexual contact with a male partner in whom either gonococcal or chlamydial urethritis or nongonococcal urethritis was diagnosed. Compared to subjects with normal vaginal flora, subjects with bacterial vaginosis were more likely to test positive for Neisseria gonorrhoeae (odds ratio [OR], 4.1; 95% confidence interval [CI], 1.7-9.7) and Chlamydia trachomatis (OR, 3.4; 95% CI, 1.5-7.8). Subjects colonized vaginally by hydrogen peroxide-producing lactobacilli were less likely to receive a diagnosis of chlamydial infection or gonorrhea than subjects without such lactobacilli. Bacterial vaginosis was a strong predictor of gonorrhea and chlamydial infection among subjects who reported recent exposure to a male partner with urethritis. These data support the importance of vaginal flora in the defense against STD acquisition.
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ISSN:1537-6591
1537-6591
DOI:10.1086/367658