Epigenetic and integrative cross-omics analyses of cerebral white matter hyperintensities on MRI

Cerebral white matter hyperintensities on MRI are markers of cerebral small vessel disease, a major risk factor for dementia and stroke. Despite the successful identification of multiple genetic variants associated with this highly heritable condition, its genetic architecture remains incompletely u...

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Veröffentlicht in:	Brain (London, England : 1878) Jg. 146; H. 2; S. 492
Hauptverfasser:	Yang, Yunju, Knol, Maria J, Wang, Ruiqi, Mishra, Aniket, Liu, Dan, Luciano, Michelle, Teumer, Alexander, Armstrong, Nicola, Bis, Joshua C, Jhun, Min A, Li, Shuo, Adams, Hieab H H, Aziz, Nasir Ahmad, Bastin, Mark E, Bourgey, Mathieu, Brody, Jennifer A, Frenzel, Stefan, Gottesman, Rebecca F, Hosten, Norbert, Hou, Lifang, Kardia, Sharon L R, Lohner, Valerie, Marquis, Pascale, Maniega, Susana Muñoz, Satizabal, Claudia L, Sorond, Farzaneh A, Valdés Hernández, Maria C, van Duijn, Cornelia M, Vernooij, Meike W, Wittfeld, Katharina, Yang, Qiong, Zhao, Wei, Boerwinkle, Eric, Levy, Daniel, Deary, Ian J, Jiang, Jiyang, Mather, Karen A, Mosley, Thomas H, Psaty, Bruce M, Sachdev, Perminder S, Smith, Jennifer A, Sotoodehnia, Nona, DeCarli, Charles S, Breteler, Monique M B, Ikram, M Arfan, Grabe, Hans J, Wardlaw, Joanna, Longstreth, W T, Launer, Lenore J, Seshadri, Sudha, Debette, Stephanie, Fornage, Myriam
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	England 13.02.2023
Schlagworte:	Aged Brain - diagnostic imaging DNA Methylation - genetics Epigenesis, Genetic Genome-Wide Association Study - methods Humans Magnetic Resonance Imaging Middle Aged Protein-Arginine N-Methyltransferases Repressor Proteins White Matter - diagnostic imaging blood–brain barrier dysfunction cerebral small vessel disease epigenome-wide association study integrative cross-omics analysis white matter hyperintensities
ISSN:	1460-2156, 1460-2156
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