Tocilizumab Dose Tapering Based on a Model-Based Algorithm is Feasible in Clinical Practice: A Short Communication

Tocilizumab in the treatment of rheumatoid arthritis (RA) is a potential candidate for concentration-guided tapering because the standard dose of tocilizumab results in a wide range of serum concentrations, usually above the presumed therapeutic window, and an exposure-response relationship has been...

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Bibliographic Details
Published in:	Therapeutic drug monitoring Vol. 46; no. 3; p. 410
Main Authors:	Hooijberg, Femke, Layegh, Zohra, Leeuw, Maureen, Boekel, Laura, van den Berg, Stefan P H, Ruwaard, Jill, Bastida, Carla, Huitema, Alwin D R, Pel, Sara, Elkayam, Ori, de Vries, Annick, Nurmohamed, Mike, Rispens, Theo, Dorlo, Thomas P C, Wolbink, Gertjan
Format:	Journal Article
Language:	English
Published:	United States 01.06.2024
Subjects:	Adult Aged Algorithms Antibodies, Monoclonal, Humanized - administration & dosage Antibodies, Monoclonal, Humanized - pharmacokinetics Antibodies, Monoclonal, Humanized - therapeutic use Antirheumatic Agents - administration & dosage Antirheumatic Agents - blood Antirheumatic Agents - pharmacokinetics Antirheumatic Agents - therapeutic use Arthritis, Rheumatoid - drug therapy Dose-Response Relationship, Drug Double-Blind Method Drug Monitoring - methods Drug Tapering - methods Feasibility Studies Female Humans Male Middle Aged
ISSN:	1536-3694, 1536-3694
Online Access:	Get more information
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