Enantio- and Diastereoselective Syntheses of 3-Hydroxypiperidines through Iridium-Catalyzed Allylic Substitution

Stereoselective syntheses of 3‐hydroxypiperidines have been developed. Key intermediates are N‐protected allylamines that are prepared by an enantioselective iridium‐catalyzed allylic amination. A subsequent catch and release procedure that involves an epoxidation and base‐mediated elimination yield...

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Vydané v:	European journal of organic chemistry Ročník 2013; číslo 23; s. 5149 - 5159
Hlavní autori:	Hoecker, Johannes, Rudolf, Georg C., Bächle, Florian, Fleischer, Steffen, Lindner, Benjamin D., Helmchen, Günter
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	Weinheim WILEY-VCH Verlag 01.08.2013 WILEY‐VCH Verlag Wiley Wiley Subscription Services, Inc
Predmet:	Alkaloids Amination Azasugars Chemistry Chemistry, Organic Epoxidation Iridium Lactams Nitrogen heterocycles Pharmaceutical industry Physical Sciences Science & Technology Lactams DEOXYMANNOJIRIMYCIN Azasugars Alkaloids CARBONYLATION Nitrogen heterocycles Amination PIPERIDINE Epoxidation ENANTIOSELECTIVE SYNTHESES Iridium STEREOSELECTIVE-SYNTHESIS ASYMMETRIC TOTAL-SYNTHESIS DERIVATIVES EFFICIENT CYCLIZATION
ISSN:	1434-193X, 1099-0690
On-line prístup:	Získať plný text
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