Validation of three coding algorithms to identify patients with end-stage liver disease in an administrative database

ABSTRACT Purpose Use of administrative or population‐based databases for post‐marketing pharmacoepidemiology research in patients with end‐stage liver disease (ESLD) has been limited by the difficulty of accurately identifying such patients. Algorithms to identify patients with ESLD using ICD‐9‐CM c...

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Veröffentlicht in:Pharmacoepidemiology and drug safety Jg. 21; H. 7; S. 765 - 769
Hauptverfasser: Goldberg, D, Lewis, JD, Halpern, SD, Weiner, Mark, Lo Re III, Vincent
Format: Journal Article
Sprache:Englisch
Veröffentlicht: Chichester, UK John Wiley & Sons, Ltd 01.07.2012
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Schlagworte:
Algorithms
cirrhosis
end-stage liver disease
Epidemiology
hepatic decompensation
ICD-9-CM code
Liver diseases
Medical coding
pharmacoepidemiology
Pharmacology
validation
ISSN:1053-8569, 1099-1557, 1099-1557
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Zusammenfassung:ABSTRACT Purpose Use of administrative or population‐based databases for post‐marketing pharmacoepidemiology research in patients with end‐stage liver disease (ESLD) has been limited by the difficulty of accurately identifying such patients. Algorithms to identify patients with ESLD using ICD‐9‐CM codes have not been developed outside of the Veterans Affairs healthcare setting. Methods We queried electronic medical records at two tertiary care hospitals to identify patients with ICD‐9‐CM codes indicative of ESLD. Coding algorithms were developed to identify patients with confirmed ESLD, and these were tested to determine their positive predictive value (PPV). Results The presence of one inpatient or outpatient ICD‐9‐CM code for: (i) cirrhosis; (ii) chronic liver disease, and (iii) a hepatic decompensation event yielded a PPV of 85.2% (167/196; 95% CI: 79.4%–89.9%). The PPV increased to 89.3% (150/168; 95% CI: 83.6%–93.5%) when the algorithm required two or more ICD‐9‐CM codes for a hepatic decompensation. However, an algorithm requiring only one ICD‐9‐CM code for (i) cirrhosis and (ii) a hepatic decompensation event, in the absence of a chronic liver disease code, yielded a PPV of 85.7% (30/35; 95% CI: 69.7%‐95.2%). Conclusions A coding algorithm that includes at least one ICD‐9‐CM code for cirrhosis plus one ICD‐9‐CM code for a hepatic decompensation event has a high PPV for identifying patients with ESLD. The inclusion of at least two codes indicative of a hepatic decompensation event increased the PPV. This algorithm can be used in future epidemiologic studies to examine the outcomes of a variety of long‐term medical therapies in patients with ESLD. Copyright © 2012 John Wiley & Sons, Ltd.
Bibliographie:VLR - No. NIH/NIAID K01 AI-070001
JL - No. NIH K24-DK078228
DG - No. NIH/NIDDK F32 1-F32-DK-089694-01
ark:/67375/WNG-3VCCJHBN-4
ArticleID:PDS3290
istex:DC90E7494907D3F397279E7E1E6A41DBAF6261F8
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:1053-8569
1099-1557
1099-1557
DOI:10.1002/pds.3290