Stroke and Bleeding in Atrial Fibrillation with Chronic Kidney Disease

Chronic Kidney Disease in Atrial Fibrillation In a study of data from Danish national registries, CKD was associated with an increased risk of stroke and bleeding among patients with atrial fibrillation. Warfarin decreased the risk of stroke among such patients. Both warfarin and aspirin increased t...

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Bibliographic Details
Published in:The New England journal of medicine Vol. 367; no. 7; pp. 625 - 635
Main Authors: Olesen, Jonas Bjerring, Lip, Gregory Y.H, Kamper, Anne-Lise, Hommel, Kristine, Køber, Lars, Lane, Deirdre A, Lindhardsen, Jesper, Gislason, Gunnar Hilmar, Torp-Pedersen, Christian
Format: Journal Article
Language:English
Published: Waltham, MA Massachusetts Medical Society 16.08.2012
Subjects:
Age
Aged
Aspirin
Aspirin - adverse effects
Aspirin - therapeutic use
Atrial Fibrillation - complications
Atrial Fibrillation - drug therapy
Biological and medical sciences
Bleeding
Cardiac arrhythmia
Cardiac dysrhythmias
Cardiology. Vascular system
Disease
End-stage renal disease
Female
Fibrillation
General aspects
Heart
Heart attacks
Hematologic Agents - adverse effects
Hematologic Agents - therapeutic use
Hemodialysis
Hemorrhage - etiology
Humans
Kidney diseases
Kidney Failure, Chronic - complications
Male
Medical sciences
Myocardial Infarction - etiology
Neurology
Patients
Population
Proportional Hazards Models
Renal Insufficiency, Chronic - complications
Renal Insufficiency, Chronic - therapy
Renal Replacement Therapy
Risk
Stroke
Stroke - etiology
Thromboembolism
Thromboembolism - prevention & control
Transplants & implants
Vascular diseases and vascular malformations of the nervous system
Warfarin
Warfarin - adverse effects
Warfarin - therapeutic use
Denmark
Kidney disease
Nervous system diseases
Stroke
Urinary system disease
Arrhythmia
Atrial fibrillation
Cardiovascular disease
Chronic kidney disease
Hemorrhage
Excitability disorder
Cerebral disorder
Vascular disease
Medicine
Heart disease
Renal failure
Central nervous system disease
Cerebrovascular disease
ISSN:0028-4793, 1533-4406, 1533-4406
Online Access:Get full text
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Summary:Chronic Kidney Disease in Atrial Fibrillation In a study of data from Danish national registries, CKD was associated with an increased risk of stroke and bleeding among patients with atrial fibrillation. Warfarin decreased the risk of stroke among such patients. Both warfarin and aspirin increased the risk of bleeding. The prevalence of both atrial fibrillation and chronic kidney disease increases with age. 1 , 2 The prevalence of atrial fibrillation is 2.3% among persons 40 years of age or older and 5.9% among those 65 years of age or older, 2 and the prevalence of end-stage renal disease increases from approximately 3.5% among persons 45 to 64 years of age to nearly 6% among those 75 years of age or older. 1 Many patients have both disorders, 3 – 6 and the number of such patients is increasing, owing in part to the aging population and the improved survival in both diseases. Atrial fibrillation increases . . .
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ISSN:0028-4793
1533-4406
1533-4406
DOI:10.1056/NEJMoa1105594