Glycopolymer Code: Programming Synthetic Macromolecules for Biological Targeting

Targeting in a cellular level is still one of the major challenges in biomedical treatments. However, new synthetic and analytical techniques now allow the development of precisely prepared macromolecules. Thus, glycopolymer chains are reported to be prepared with controlled length, monomer sequence...

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Bibliographic Details
Published in:Macromolecular chemistry and physics Vol. 221; no. 7
Main Authors: Yilmaz, Gokhan, Becer, Caglar Remzi
Format: Journal Article
Language:English
Published: Weinheim Wiley Subscription Services, Inc 01.04.2020
Subjects:
Biomedical materials
Chains
glycan
glycocodes
Glycopolymers
glycopolymer–lectin interactions
Macromolecules
Selectivity
ISSN:1022-1352, 1521-3935
Online Access:Get full text
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Summary:Targeting in a cellular level is still one of the major challenges in biomedical treatments. However, new synthetic and analytical techniques now allow the development of precisely prepared macromolecules. Thus, glycopolymer chains are reported to be prepared with controlled length, monomer sequences, as well as chain‐folded structures. A high level of complexity in synthetic macromolecules also allows increased selectivity in targeting, which is a key factor in biomedical applications. Understanding the glycopolymer code is very crucial to design more suitable and functional glycopolymers for better approaches in biological and medical applications. When a great deal of interest in carbohydrate‐based systems is considered, it is not far from providing specific coding to glycopolymers.
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ISSN:1022-1352
1521-3935
DOI:10.1002/macp.202000006