Role of Platelet-Derived Tgfβ1 in the Progression of Ovarian Cancer

Transforming growth factor β1 (Tgfβ1) plays an important role in cancer. Most of Tgfβ1 in plasma is from platelets; thus, we studied whether platelet Tgfβ1 has any role in the progression of ovarian cancer, and whether this role is limited to metastasis or also involves the growth of primary tumors....

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Veröffentlicht in:	Clinical cancer research Jg. 23; H. 18; S. 5611
Hauptverfasser:	Hu, Qianghua, Hisamatsu, Takeshi, Haemmerle, Monika, Cho, Min Soon, Pradeep, Sunila, Rupaimoole, Rajesha, Rodriguez-Aguayo, Cristian, Lopez-Berestein, Gabriel, Wong, Stephen T C, Sood, Anil K, Afshar-Kharghan, Vahid
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 15.09.2017
Schlagworte:	Animals Blood Platelets - metabolism Cell Line, Tumor Cell Proliferation Disease Models, Animal Disease Progression Female Gene Expression Heterografts Humans Immunohistochemistry Mice Mice, Transgenic Neovascularization, Pathologic - genetics Neovascularization, Pathologic - metabolism Ovarian Neoplasms - genetics Ovarian Neoplasms - metabolism Ovarian Neoplasms - pathology RNA, Small Interfering - genetics Time Factors Transforming Growth Factor beta1 - genetics Transforming Growth Factor beta1 - metabolism Tumor Burden
ISSN:	1078-0432, 1557-3265, 1557-3265
Online-Zugang:	Weitere Angaben
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