Quantity and quality of gait and turning in people with multiple sclerosis, Parkinson’s disease and matched controls during daily living

Clinical trials need to specify which specific gait characteristics to monitor as mobility measures for each neurological disorder. As a first step, this study aimed to investigate a set of measures from daily-life monitoring that best discriminate mobility between people with multiple sclerosis (MS...

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Bibliographic Details
Published in:Journal of neurology Vol. 267; no. 4; pp. 1188 - 1196
Main Authors: Shah, Vrutangkumar V., McNames, James, Mancini, Martina, Carlson-Kuhta, Patricia, Spain, Rebecca I., Nutt, John G., El-Gohary, Mahmoud, Curtze, Carolin, Horak, Fay B.
Format: Journal Article
Language:English
Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.04.2020
Springer Nature B.V
Subjects:
Activities of Daily Living
Aged
Biomechanical Phenomena
Clinical trials
Cytotoxicity
Female
Gait
Gait Disorders, Neurologic - diagnosis
Gait Disorders, Neurologic - etiology
Gait Disorders, Neurologic - physiopathology
Humans
Lymphocytes T
Male
Medicine
Medicine & Public Health
Middle Aged
Mobility
Mobility Limitation
Movement disorders
Multiple sclerosis
Multiple Sclerosis - complications
Multiple Sclerosis - physiopathology
Neurodegenerative diseases
Neurological disorders
Neurology
Neuroradiology
Neurosciences
Original Communication
Parkinson Disease - complications
Parkinson Disease - physiopathology
Parkinson's disease
Severity of Illness Index
Wearable Electronic Devices
Mobility
Multiple sclerosis
Neurological disorders
Parkinson’s disease
ISSN:0340-5354, 1432-1459, 1432-1459
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Summary:Clinical trials need to specify which specific gait characteristics to monitor as mobility measures for each neurological disorder. As a first step, this study aimed to investigate a set of measures from daily-life monitoring that best discriminate mobility between people with multiple sclerosis (MS) and age-matched healthy control subjects (MS-Ctl) and between people with Parkinson’s disease (PD) and age-matched healthy control subjects (PD-Ctl). Further, we investigated how these discriminative measures relate to the disease severity of MS or PD. We recruited 13 people with MS, 21 MS-Ctl, 29 people with idiopathic PD, and 20 PD-Ctl. Subjects wore 3 inertial sensors on their feet and the lumbar back for a week. The Area Under Curves (AUC) from the receiver operator characteristic (ROC) plot was calculated for each measure to determine the objective measures that best separated the MS and PD groups from their respective control cohorts. Adherence wearing the sensors was similar among groups for 58–66 h of recording ( p  = 0.14). Quantity of mobility (activity measures, such as a median number of strides per gait bout, AUC = 0.93) best discriminated mobility impairments in MS from MS-Ctl. In contrast, quality of mobility (such as turn angle, AUC = 0.90) best discriminated mobility impairments in PD from PD-Ctl. Mobility measures with AUC > 0.80 were correlated with MS and PD clinical scores of disease severity. Thus, measures characterizing mobility impairments differ for MS versus PD during daily life suggesting that mobility measures for clinical trials and clinical practice need to be specific to each neurological disorder.
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ISSN:0340-5354
1432-1459
1432-1459
DOI:10.1007/s00415-020-09696-5