A mini-review of the diffusion dynamics of DNA-binding proteins: experiments and models

In the course of various biological processes, specific DNA-binding proteins must efficiently find a particular target sequence/protein or a damaged site on the DNA. DNA-binding proteins perform this task based on diffusion. Nevertheless, investigations over recent decades have found that the diffus...

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Veröffentlicht in:Journal of the Korean Physical Society Jg. 78; H. 5; S. 408 - 426
Hauptverfasser: Park, Seongyu, Lee, O-chul, Durang, Xavier, Jeon, Jae-Hyung
Format: Journal Article
Sprache:Englisch
Veröffentlicht: Seoul The Korean Physical Society 01.03.2021
Springer Nature B.V
한국물리학회
Schlagworte:
Binding
Biological activity
Deoxyribonucleic acid
Diffusion
DNA
Mathematical and Computational Physics
Particle and Nuclear Physics
Physics
Physics and Astronomy
Proteins
Review
Theoretical
물리학
Sliding
Hopping
DNA-binding protein
Anomalous diffusion
Facilitated diffusion
ISSN:0374-4884, 1976-8524
Online-Zugang:Volltext
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Zusammenfassung:In the course of various biological processes, specific DNA-binding proteins must efficiently find a particular target sequence/protein or a damaged site on the DNA. DNA-binding proteins perform this task based on diffusion. Nevertheless, investigations over recent decades have found that the diffusion dynamics of DNA-binding proteins are generally complicated and, further, protein specific. In this review, we collect experimental and theoretical studies that quantify the diffusion dynamics of DNA-binding proteins and review them from the viewpoint of diffusion processes.
Bibliographie:ObjectType-Article-1
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ISSN:0374-4884
1976-8524
DOI:10.1007/s40042-021-00060-y