A mini-review of the diffusion dynamics of DNA-binding proteins: experiments and models

In the course of various biological processes, specific DNA-binding proteins must efficiently find a particular target sequence/protein or a damaged site on the DNA. DNA-binding proteins perform this task based on diffusion. Nevertheless, investigations over recent decades have found that the diffus...

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Vydáno v:Journal of the Korean Physical Society Ročník 78; číslo 5; s. 408 - 426
Hlavní autoři: Park, Seongyu, Lee, O-chul, Durang, Xavier, Jeon, Jae-Hyung
Médium: Journal Article
Jazyk:angličtina
Vydáno: Seoul The Korean Physical Society 01.03.2021
Springer Nature B.V
한국물리학회
Témata:
Binding
Biological activity
Deoxyribonucleic acid
Diffusion
DNA
Mathematical and Computational Physics
Particle and Nuclear Physics
Physics
Physics and Astronomy
Proteins
Review
Theoretical
물리학
Sliding
Hopping
DNA-binding protein
Anomalous diffusion
Facilitated diffusion
ISSN:0374-4884, 1976-8524
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Shrnutí:In the course of various biological processes, specific DNA-binding proteins must efficiently find a particular target sequence/protein or a damaged site on the DNA. DNA-binding proteins perform this task based on diffusion. Nevertheless, investigations over recent decades have found that the diffusion dynamics of DNA-binding proteins are generally complicated and, further, protein specific. In this review, we collect experimental and theoretical studies that quantify the diffusion dynamics of DNA-binding proteins and review them from the viewpoint of diffusion processes.
Bibliografie:ObjectType-Article-1
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ISSN:0374-4884
1976-8524
DOI:10.1007/s40042-021-00060-y