Stable human regulatory T cells switch to glycolysis following TNF receptor 2 costimulation

Following activation, conventional T (T conv ) cells undergo an mTOR-driven glycolytic switch. Regulatory T (T reg ) cells reportedly repress the mTOR pathway and avoid glycolysis. However, here we demonstrate that human thymus-derived T reg (tT reg ) cells can become glycolytic in response to tumou...

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Veröffentlicht in:	Nature metabolism Jg. 2; H. 10; S. 1046 - 1061
Hauptverfasser:	de Kivit, Sander, Mensink, Mark, Hoekstra, Anna T., Berlin, Ilana, Derks, Rico J. E., Both, Demi, Aslam, Muhammad A., Amsen, Derk, Berkers, Celia R., Borst, Jannie
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	London Nature Publishing Group UK 01.10.2020 Nature Publishing Group
Schlagworte:	1-Phosphatidylinositol 3-kinase 631/250/1619/554 631/250/2152 631/443/319 631/45/320 Antigens Biomedical and Life Sciences Blood Carbon CD25 antigen CD3 antigen CD3 Complex - metabolism Cell activation Cell proliferation Citric Acid Cycle - drug effects Effector cells Flow cytometry Foxp3 protein Glucose Glucose - metabolism Glucose - pharmacology Glycolysis Glycolysis - drug effects Humans Immunoregulation Kinases Lactic acid Lactic Acid - blood Lactic Acid - metabolism Life Sciences Lymphocytes Lymphocytes T Metabolism Metabolites Metabolome Monoclonal antibodies Phosphatidylinositol 3-Kinases - metabolism Proteins Protocol Receptors, Tumor Necrosis Factor, Type II - drug effects Receptors, Tumor Necrosis Factor, Type II - metabolism RNA - chemistry Sequence Analysis, RNA Signal Transduction Statistical analysis T-Lymphocytes, Regulatory - metabolism Thymus TOR protein TOR Serine-Threonine Kinases - metabolism Tricarboxylic acid cycle Tumor necrosis factor receptors Tumor necrosis factor-TNF Variance analysis
ISSN:	2522-5812, 2522-5812
Online-Zugang:	Volltext
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