2-Cl-MGV-1 Ameliorates Apoptosis in the Thalamus and Hippocampus and Cognitive Deficits After Cortical Infarct in Rats

Focal cortical infarction causes neuronal apoptosis in the ipsilateral nonischemic thalamus and hippocampus, which is potentially associated with poststroke cognitive deficits. TSPO (translocator protein) is critical in regulating mitochondrial apoptosis pathways. We examined the effects of the nove...

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Vydáno v:	Stroke (1970) Ročník 48; číslo 12; s. 3366
Hlavní autoři:	Chen, Yicong, Veenman, Leo, Singh, Sukhdev, Ouyang, Fubing, Liang, Jiahui, Huang, Weixian, Marek, Ilan, Zeng, Jinsheng, Gavish, Moshe
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States 01.12.2017
Témata:	Animals Apoptosis - drug effects Carbamates - therapeutic use Cerebral Infarction - drug therapy Cerebral Infarction - pathology Cerebral Infarction - psychology Cognitive Dysfunction - etiology Cognitive Dysfunction - prevention & control Cognitive Dysfunction - psychology Hippocampus - drug effects Hippocampus - pathology Male Maze Learning - drug effects Membrane Potential, Mitochondrial - drug effects Memory - drug effects Mitochondria - drug effects Neuroglia - drug effects Neuroglia - pathology Neurons - pathology Neuroprotective Agents - therapeutic use Quinazolines - therapeutic use Rats Rats, Inbred SHR Rats, Sprague-Dawley Receptors, GABA - biosynthesis Receptors, GABA - genetics Thalamus - drug effects Thalamus - pathology apoptosis infarction, middle cerebral artery rats cognition hippocampus thalamus
ISSN:	1524-4628, 1524-4628
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