The Clinical Significance and Application of Vascular Stiffness Measurements

Increasing evidence points out at vascular stiffness (and in particular aortic stiffness measured by pulse wave velocity) as a reliable biomarker of vascular aging, able to integrate in a single measure the overall burden of cardiovascular (CV) risk factors on the vasculature over time; furthermore,...

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Bibliographic Details
Published in:American journal of hypertension Vol. 32; no. 1; p. 4
Main Authors: Boutouyrie, Pierre, Bruno, Rosa-Maria
Format: Journal Article
Language:English
Published: United States 01.01.2019
Subjects:
Age Factors
Aging
Arterial Pressure
Cardiovascular Diseases - diagnosis
Cardiovascular Diseases - epidemiology
Cardiovascular Diseases - physiopathology
Cardiovascular Diseases - therapy
Humans
Predictive Value of Tests
Prognosis
Pulse Wave Analysis
Risk Factors
Vascular Stiffness
ISSN:1941-7225, 1941-7225
Online Access:Get more information
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Summary:Increasing evidence points out at vascular stiffness (and in particular aortic stiffness measured by pulse wave velocity) as a reliable biomarker of vascular aging, able to integrate in a single measure the overall burden of cardiovascular (CV) risk factors on the vasculature over time; furthermore, it may be per se a mechanism of disease, by inducing microcirculatory damage and favoring CV events. Increased aortic stiffness has been shown to predict future CV events and improve risk reclassification in those at intermediate risk. However, several questions in this field are still open, limiting the wide use of these tools in the clinical practice. This article will review the basic aspects of physiology of large artery stiffness, as well as current evidence about its possible clinical applications.
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ISSN:1941-7225
1941-7225
DOI:10.1093/ajh/hpy145