Comparison between the effects of diallyl tetrasulfide on human retina pigment epithelial cells (ARPE-19) and HCT116 cells

Diallyl mono- and polysulfanes from garlic are known to induce an adaptive cell response and the formation of antioxidants in cancer cells. In the case of a severe ER stress and a failure in the response, cancer cells eventually go into apoptosis. Only little is known about the response of normal ce...

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Bibliographic Details
Published in:	Biochimica et biophysica acta Vol. 1830; no. 11; pp. 5267 - 5276
Main Authors:	Saidu, Nathaniel Edward Bennett, Abu Asali, Imad, Czepukojc, Brigitte, Seitz, Berthold, Jacob, Claus, Montenarh, Mathias
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier B.V 01.11.2013
Subjects:	Allyl Compounds - pharmacology anticarcinogenic activity Antioxidants Apoptosis Apoptosis - drug effects Apoptosis - genetics Cell Line, Tumor Cell Survival - drug effects Cell Survival - genetics cell viability dose response Down-Regulation - drug effects Endoplasmic Reticulum - drug effects Endoplasmic Reticulum - genetics Endoplasmic Reticulum - metabolism epithelial cells Epithelial Cells - drug effects Epithelial Cells - metabolism Epithelial Cells - pathology ER stress signalling garlic Garlic - metabolism HCT116 Cells heme Heme Oxygenase-1 - genetics Heme Oxygenase-1 - metabolism Humans hydrogen peroxide Hydrogen Peroxide - metabolism neoplasm cells Normal cells proteins Reactive oxygen species Reactive Oxygen Species - metabolism retina Retina - drug effects Retina - metabolism Retina - pathology signal transduction Signal Transduction - drug effects Signal Transduction - genetics stress response Sulfhydryl Compounds - metabolism Sulfides - pharmacology superoxide anion Superoxides - metabolism Thiols Up-Regulation - drug effects Western blotting Antioxidants Reactive oxygen species Normal cells Thiols ER stress signalling Apoptosis
ISSN:	0304-4165, 0006-3002, 1872-8006
Online Access:	Get full text
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