Therapeutic potency of mTOR signaling pharmacological inhibitors in the treatment of proinflammatory diseases, current status, and perspectives

Mammalian target of rapamycin (mTOR) signaling pathway controls cell energy metabolism. There is an interplay between mTOR and proinflammatory signaling pathways, supporting the role of the pathway in the pathogenesis of inflammatory diseases. Inhibition of mTOR signaling using specific pharmacologi...

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Veröffentlicht in:	Journal of cellular physiology Jg. 233; H. 6; S. 4783 - 4790
Hauptverfasser:	Soltani, Arash, Bahreyni, Amirhossein, Boroumand, Nadia, Roshan, Mostafa karimi, Khazaei, Majid, Ryzhikov, Mikhail, Soleimanpour, Saman, Avan, Amir, Hassanian, Seyed Mahdi
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States Wiley Subscription Services, Inc 01.06.2018
Schlagworte:	Animals Anti-Inflammatory Agents - therapeutic use Arteriosclerosis Arthritis Arthritis, Rheumatoid - drug therapy Arthritis, Rheumatoid - enzymology Arthritis, Rheumatoid - immunology Atherosclerosis Atherosclerosis - drug therapy Atherosclerosis - enzymology Atherosclerosis - immunology Cancer Energy metabolism Humans inflamatory diseases inflammation Inflammation - drug therapy Inflammation - enzymology Inflammation - immunology Inflammation Mediators - antagonists & inhibitors Inflammation Mediators - immunology Inflammation Mediators - metabolism Inflammatory diseases Inhibitor drugs Inhibitors mammalian target of rapamycin Metabolism Molecular Targeted Therapy Neoplasms - drug therapy Neoplasms - enzymology Neoplasms - immunology Neurodegenerative diseases Neurodegenerative Diseases - drug therapy Neurodegenerative Diseases - enzymology Neurodegenerative Diseases - immunology Neurological diseases Pathogenesis pharmacological inhibitors Pharmacology Protein Kinase Inhibitors - therapeutic use Rapamycin Rheumatoid arthritis Sepsis Sepsis - drug therapy Sepsis - enzymology Sepsis - immunology Signal transduction Signal Transduction - drug effects Signaling TOR protein TOR Serine-Threonine Kinases - antagonists & inhibitors TOR Serine-Threonine Kinases - immunology TOR Serine-Threonine Kinases - metabolism inflamatory diseases pharmacological inhibitors mammalian target of rapamycin inflammation
ISSN:	0021-9541, 1097-4652, 1097-4652
Online-Zugang:	Volltext
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Zusammenfassung:	Mammalian target of rapamycin (mTOR) signaling pathway controls cell energy metabolism. There is an interplay between mTOR and proinflammatory signaling pathways, supporting the role of the pathway in the pathogenesis of inflammatory diseases. Inhibition of mTOR signaling using specific pharmacological inhibitors could offer therapeutic promise in several inflammatory‐associated diseases. In this review, we summarize recent findings on the regulatory effects of mTOR signaling on inflammation and the therapeutic potency of mTOR pharmacological inhibitors in the treatment of inflammatory diseases including cancer, neurodegenerative diseases, atherosclerosis, sepsis, and rheumatoid arthritis for a better understanding and hence a better management of these diseases. In this review, we summarize recent findings on the regulatory effects of mTOR signaling on inflammation and the therapeutic potency of mTOR pharmacological inhibitors in the treatment of inflammatory diseases including cancer, neurodegenerative diseases, atherosclerosis, sepsis, and rheumatoid arthritis for a better understanding and hence a better management of these diseases.
Bibliographie:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 ObjectType-Review-3 content type line 23
ISSN:	0021-9541 1097-4652 1097-4652
DOI:	10.1002/jcp.26276