Cell proliferation and cell death during whole‐body regeneration in the demosponge Halisarca dujardinii

Sponges (phylum Porifera) are early‐branching metazoans demonstrating an outstanding example of whole‐body regeneration, cell reaggregation. During the process, single cells form aggregates capable of progressive development and reconstruction of intact sponges. This study provides the first compreh...

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Published in:FEBS letters Vol. 599; no. 12; pp. 1698 - 1716
Main Authors: Lavrov, Andrey I., Melnikov, Nikolai P., Bolshakov, Fyodor V., Saidov, Daniyal M., Le Goff, Emilie, Skorentseva, Kseniia V., Frolova, Veronika S., Ereskovsky, Alexander V.
Format: Journal Article
Language:English
Published: England Wiley 01.06.2025
Subjects:
Animal biology
Animals
Cell Death
Cell Movement
Cell Proliferation
cell reaggregation
Cellular Biology
Demospongiae
Invertebrate Zoology
Life Sciences
morphallaxis
Porifera
Porifera - cytology
Porifera - physiology
Regeneration - physiology
Subcellular Processes
Demospongiae
morphallaxis
cell reaggregation
cell death
cell proliferation
Porifera
sponges
FEBS Letters cell reaggregation
FEBS Letters cell reaggregation morphallaxis cell proliferation cell death sponges Porifera Demospongiae FEBS Letters cell reaggregation morphallaxis cell proliferation cell death sponges Porifera Demospongiae
Demospongiae FEBS Letters cell reaggregation
ISSN:0014-5793, 1873-3468, 1873-3468
Online Access:Get full text
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Summary:Sponges (phylum Porifera) are early‐branching metazoans demonstrating an outstanding example of whole‐body regeneration, cell reaggregation. During the process, single cells form aggregates capable of progressive development and reconstruction of intact sponges. This study provides the first comprehensive analysis of cell proliferation and cell death during cell reaggregation in a marine demosponge, Halisarca dujardinii. Relatively high proliferative activity occurs at the early and late stages of the reaggregation. This proliferation seems to be a consequence of intact tissue turnover rather than a prerequisite for aggregate development. The contribution of cell death is limited to a short period during the aggregate epithelization. Cell reaggregation in demosponges appears to be a morphallactic restorative process relying primarily on cell migration, dedifferentiation, and transdifferentiation. Сell reaggregation is an outstanding example of regenerative abilities in sponges (phylum Porifera). During the process, single cells reconstruct an intact sponge through an elaborated developmental process relying on an intensive and diverse set of cellular rearrangements. This study provides the first comprehensive analysis of cell proliferation and cell death during cell reaggregation in a marine demosponge, Halisarca dujardinii.
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ISSN:0014-5793
1873-3468
1873-3468
DOI:10.1002/1873-3468.70025