Prevalence and clinical aspects of mild cognitive impairment in Parkinson's disease: A meta‐analysis

Mild cognitive impairment associated with Parkinson's disease (PD) is a risk factor for the development of dementia. Despite the importance of early identification of mild cognitive impairment in PD, its prevalence and clinical correlates are still debated. The present meta‐analysis provides a...

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Vydáno v:Movement disorders Ročník 35; číslo 1; s. 45 - 54
Hlavní autoři: Baiano, Chiara, Barone, Paolo, Trojano, Luigi, Santangelo, Gabriella
Médium: Journal Article
Jazyk:angličtina
Vydáno: Hoboken, USA John Wiley & Sons, Inc 01.01.2020
Wiley Subscription Services, Inc
Témata:
Age Factors
Clinical aspects
Cognitive ability
cognitive decline
Cognitive Dysfunction - complications
Cognitive Dysfunction - epidemiology
Confidence intervals
Dementia disorders
Emotional behavior
Gait
Humans
Levodopa
Meta-analysis
Mild cognitive impairment
Movement disorders
Neurodegenerative diseases
Neuropsychological Tests
nonmotor symptoms
Parkinson Disease - complications
Parkinson Disease - enzymology
Parkinson's disease
Prevalence
Quality of life
Risk Factors
prevalence
Parkinson's disease
cognitive decline
Mild cognitive impairment
nonmotor symptoms
ISSN:0885-3185, 1531-8257, 1531-8257
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Shrnutí:Mild cognitive impairment associated with Parkinson's disease (PD) is a risk factor for the development of dementia. Despite the importance of early identification of mild cognitive impairment in PD, its prevalence and clinical correlates are still debated. The present meta‐analysis provides a robust estimate of prevalence rate of mild cognitive impairment in PD according to the Movement Disorder Society clinical criteria and to explore the differences between PD patients with and without mild cognitive impairment in demographic, clinical, and neuropsychiatric features. A systematic literature search was performed up to April 2019 using PsycInfo (PROQUEST), PubMed, and Scopus. From 4706 titles and s, 41 studies were selected (n = 7053 patients). Pooled mild cognitive impairment prevalence was 40% on a total sample of 7053 PD patients (95% confidence interval = 36–44; Q = 490.14, P < 0.0001; I2 = 91.84%) with a higher frequency for the multiple domain subtype (31%; 95% confidence interval = 23–41, Q = 93.24; P < 0.0001; I2 = 92.49%). Meta‐regression analysis revealed that stage of PD moderate prevalence estimates of mild cognitive impairment (β = 2.80; P = 0.008). Mild cognitive impairment in PD was associated with older age, lower education, longer disease duration, higher levodopa equivalent daily dose, more severe motor symptoms, and postural instability/gait difficulty motor subtype, poorer quality of life, higher levels of apathy, and depression. The present meta‐analysis indicated that mild cognitive impairment in PD is a frequent cognitive status deserving to be early detected by means of standardized cognitive assessments in clinical practice. © 2019 International Parkinson and Movement Disorder Society
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ISSN:0885-3185
1531-8257
1531-8257
DOI:10.1002/mds.27902