Role of thrombin in the pathogenesis of atherosclerosis

Atherosclerosis is an arterial disease associated with inflammation. Thrombin is a procoagulant and proinflammatory serine protease that contributes to the pathology of atherosclerosis by enhancing the expression of cell adhesion molecules, inducing the secretion of proinflammatory cytokines, activa...

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Published in:Journal of cellular biochemistry Vol. 120; no. 4; pp. 4757 - 4765
Main Authors: Jaberi, Najmeh, Soleimani, Atena, Pashirzad, Mehran, Abdeahad, Hosein, Mohammadi, Fariba, Khoshakhlagh, Mahdieh, Khazaei, Majid, Ferns, Gordon A, Avan, Amir, Hassanian, Seyed Mahdi
Format: Journal Article
Language:English
Published: United States Wiley Subscription Services, Inc 01.04.2019
Subjects:
Aorta
Arteriosclerosis
Atherosclerosis
Cardiovascular diseases
Cardiovascular system
Cell adhesion
Cell adhesion & migration
Cell adhesion molecules
Cell proliferation
Cytokines
Heart diseases
inflammation
Inhibitor drugs
Inhibitors
Lesions
Muscles
Pathogenesis
Pharmacology
Plaques
Serine
Serine proteinase
Smooth muscle
Thrombin
thrombin inhibitors
atherosclerosis
thrombin
inflammation
thrombin inhibitors
ISSN:0730-2312, 1097-4644, 1097-4644
Online Access:Get full text
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Summary:Atherosclerosis is an arterial disease associated with inflammation. Thrombin is a procoagulant and proinflammatory serine protease that contributes to the pathology of atherosclerosis by enhancing the expression of cell adhesion molecules, inducing the secretion of proinflammatory cytokines, activating inflammatory responses in atherosclerotic plaques, stimulating proliferation of aortic smooth muscle cells, and exacerbating vascular lesions at sites of injury. Hence, thrombin appears to be an important target for treatment of atherosclerosis and thrombin pharmacological inhibitors have significant therapeutic potency for suppressing inflammatory responses in cardiovascular diseases. This review summarizes the proinflammatory signaling functions of thrombin as well as the therapeutic potency of thrombin inhibitors in the pathogenesis of atherosclerosis and hence their potential therapeutic value in this condition. This review summarizes the proinflammatory signaling functions of thrombin as well as the therapeutic potency of thrombin inhibitors in the pathogenesis of atherosclerosis and hence their potential therapeutic value in this condition.
Bibliography:Najmeh Jaberi, Atena Soleimani, Mehran Pashirzad, Hosein Abdeahad, Fariba Mohammadi, and Mahdieh Khoshakhlagh have contributed equally to this study.
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ISSN:0730-2312
1097-4644
1097-4644
DOI:10.1002/jcb.27771